Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Kandhare AD et al. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. 2013 Fundam Clin Pharmacol pmid:23057828
Bayir A et al. The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning. 2013 Hum Exp Toxicol pmid:23060413
Kaur J et al. Sphingobium baderi sp. nov., isolated from a hexachlorocyclohexane dump site. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544800
Niharika N et al. Novosphingobium barchaimii sp. nov., isolated from hexachlorocyclohexane-contaminated soil. 2013 Int. J. Syst. Evol. Microbiol. pmid:22544801
Sheu SY et al. Gemmobacter lanyuensis sp. nov., isolated from a freshwater spring. 2013 Int. J. Syst. Evol. Microbiol. pmid:23728371
Matsushita N et al. Enhanced water dispersibility of coenzyme Q10 by complexation with albumin hydrolysate. 2013 J. Agric. Food Chem. pmid:23731056
Mutations in COQ2 in familial and sporadic multiple-system atrophy. 2013 N. Engl. J. Med. pmid:23758206
Fredericks WJ et al. Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism. 2013 Int. J. Oncol. pmid:23759948
Morris G et al. Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications. 2013 Mol. Neurobiol. pmid:23761046
DZugkoev SG et al. [Influence of combined treatment on biochemical and functional characteristics in patients with vascular complications of type 1 diabetes mellitus and different pathways of compensation]. 2013 Klin Med (Mosk) pmid:23718058
Zhang R et al. Thioclava dalianensis sp. nov., isolated from surface seawater. 2013 Int. J. Syst. Evol. Microbiol. pmid:23378112
Sheu SJ et al. Resveratrol stimulates mitochondrial bioenergetics to protect retinal pigment epithelial cells from oxidative damage. 2013 Invest. Ophthalmol. Vis. Sci. pmid:24008411
Cordero MD et al. Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia? 2013 Antioxid. Redox Signal. pmid:22938055
Abad C et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. 2013 Andrologia pmid:22943406
Noh YH et al. Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes. 2013 Cell Death Dis pmid:24091663
Payton S Stones: Coenzyme Q10 protects kidney during ESWL. 2013 Nat Rev Urol pmid:24166344
Fogagnolo P et al. The effects of topical coenzyme Q10 and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study. 2013 Ophthalmologica pmid:23011409
Allan CM et al. A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae. 2013 Biochim. Biophys. Acta pmid:23270816
López LC et al. Argan oil-contained antioxidants for human mitochondria. 2013 Nat Prod Commun pmid:23472457
Safarinejad MR et al. Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. 2013 Br. J. Nutr. pmid:23199523
Dzugkoev SG et al. Effects of endogenous regulators of endothelial NO synthase on nitric oxide homeostasis and blood serum lipoproteins during experimental diabetes mellitus. 2013 Bull. Exp. Biol. Med. pmid:24319749
Lesser GJ et al. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. 2013 J Support Oncol pmid:22682875
Skroza N et al. Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment. 2013 G Ital Dermatol Venereol pmid:24442048
Kodentsova VM et al. Biochemistry of blood plasma and some parameters of antioxidant status in rats with polyhypovitaminosis of varying severity. 2013 Bull. Exp. Biol. Med. pmid:23486577
Sommerville RB et al. Coenzyme Q10 deficiency in children: frequent type 2C muscle fibers with normal morphology. 2013 Muscle Nerve pmid:23494902
Chen CC et al. Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation. 2013 J. Biol. Chem. pmid:23430247
Cicero AF and Borghi C Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. 2013 Curr. Hypertens. Rep. pmid:23430658
Niklowitz P et al. Determination of coenzyme Q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (Sus scrofa domestica). 2013 Anal. Biochem. pmid:23467099
Romanenko LA et al. Devosia submarina sp. nov., isolated from deep-sea surface sediments. 2013 Int. J. Syst. Evol. Microbiol. pmid:23416574
Potgieter M et al. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. 2013 Nutr. Rev. pmid:23452285
Theuri G et al. Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations. 2013 Growth Horm. IGF Res. pmid:23452916
Huynh K et al. Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice. 2013 Free Radic. Biol. Med. pmid:23454064
Abraham WR et al. Prosthecate sphingomonads: proposal of Sphingomonas canadensis sp. nov. 2013 Int. J. Syst. Evol. Microbiol. pmid:23456806
Fedacko J et al. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. 2013 Can. J. Physiol. Pharmacol. pmid:23458201
Cordero MD et al. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? 2013 Antioxid. Redox Signal. pmid:23458405
Zhou H et al. Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules. 2013 J Nanosci Nanotechnol pmid:23646802
Bohar Topolovec M et al. Endogenous plasma coenzyme Q10 concentration does not correlate with plasma total antioxidant capacity level in healthy untrained horses. 2013 Res. Vet. Sci. pmid:23648076
Luo J et al. A new electrochemically active bacterium phylogenetically related to Tolumonas osonensis and power performance in MFCs. 2013 Bioresour. Technol. pmid:23651598
Yoneda T et al. Anti-aging effects of co-enzyme Q10 on periodontal tissues. 2013 J. Dent. Res. pmid:23694931
Zhang YP et al. Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10. 2013 Neurobiol. Dis. pmid:23684663
Duberley KE et al. Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard. 2013 Rapid Commun. Mass Spectrom. pmid:23592193
Castro-Marrero J et al. Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia? 2013 Antioxid. Redox Signal. pmid:23600892
Simón-Yarza T et al. Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia. 2013 Int J Pharm pmid:23639291
Xue SY et al. Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. 2013 Toxicol. Sci. pmid:23640862
Itkonen O et al. Mitochondrial coenzyme Q10 determination by isotope-dilution liquid chromatography-tandem mass spectrometry. 2013 Clin. Chem. pmid:23640978
Sanoobar M et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. 2013 Int. J. Neurosci. pmid:23659338
Bibi F et al. Martelella endophytica sp. nov., an antifungal bacterium associated with a halophyte. 2013 Int. J. Syst. Evol. Microbiol. pmid:23355694
Josey BJ et al. Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. 2013 J. Med. Chem. pmid:23327468
Zhang YP et al. Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes. 2013 Anesthesiology pmid:23334664
Bogsrud MP et al. No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy. 2013 Scand. Cardiovasc. J. pmid:23301875
Kim JW et al. Effects of coenzyme Q10 on bladder dysfunction induced by chronic bladder ischemia in a rat model. 2013 J. Urol. pmid:23306086
Gladine C et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. 2013 J. Nutr. Biochem. pmid:22784432
Goldschmidt R et al. Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases. 2013 Bioorg. Med. Chem. pmid:23313093
Sato T et al. Effect of reduced form of coenzyme Q10 on cyclosporine nephrotoxicity. 2013 Exp Clin Transplant pmid:23194328
Veyisoglu A et al. Methylobacterium tarhaniae sp. nov., isolated from arid soil. 2013 Int. J. Syst. Evol. Microbiol. pmid:23315404
Estévez PN et al. Coenzyme Q10 stability in pediatric liquid oral dosage formulations. 2012 Nov-Dec Farm Hosp pmid:23461442
Ahmadvand H et al. Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats. 2012 Nov-Dec J. Diabetes Complicat. pmid:22795334
Gardner A Fibromyalgia: unknown pathogenesis and a "chicken or the egg" causality dilemma. 2012 Nov-Dec Nutrition pmid:22898266
Cordero MD et al. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. 2012 Nov-Dec Nutrition pmid:22898267
Lance J et al. Coenzyme Q10--a therapeutic agent. 2012 Nov-Dec Medsurg Nurs pmid:23477030
Brugè F et al. Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status. 2012 May-Jun Biofactors pmid:22488910
Yerramilli-Rao P et al. Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs. 2012 Jan-Feb Int. J. Toxicol. pmid:22267890
Niklowitz P et al. Coenzyme Q10 concentration in plasma and blood cells of juvenile patients hospitalized for anorexia nervosa. 2012 Jan-Feb Biofactors pmid:22311849
Mikirova N et al. The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission. 2012 Jan-Feb Altern Ther Health Med pmid:22516851
Ferreiro-Barros CC et al. Determination of a method for extraction of coenzyme Q10 in human plasma: optimization of the use of surfactants and other variables. 2012 Apr-Jun Einstein (Sao Paulo) pmid:23052456
DiNicolantonio JJ CoQ10 and L-carnitine for statin myalgia? 2012 Expert Rev Cardiovasc Ther pmid:23190071
Markley HG CoEnzyme Q10 and riboflavin: the mitochondrial connection. 2012 Headache pmid:23030537
Mancini A et al. Relationship between plasma antioxidants and thyroid hormones in chronic obstructive pulmonary disease. 2012 Exp. Clin. Endocrinol. Diabetes pmid:23073919
Vrzhesinskaia OA et al. [The effect of fatty component of diet and coenzyme Q10 on rat sufficiency with vitamins-antioxidans in chronic experiments]. 2012 Vopr Pitan pmid:23530435
Tiano L et al. Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation. 2012 Neurobiol. Aging pmid:21601315
Yoon JH et al. Marivita hallyeonensis sp. nov., isolated from seawater, reclassification of Gaetbulicola byunsanensis as Marivita byunsanensis comb. nov. and emended description of the genus Marivita Hwang et al. 2009. 2012 Int. J. Syst. Evol. Microbiol. pmid:21602362
Schmelzer C and Döring F Micronutrient special issue: coenzyme Q(10) requirements for DNA damage prevention. 2012 Mutat. Res. pmid:21964355
Keck M et al. Coenzyme Q10 does not enhance preadipocyte viability in an in vitro lipotransfer model. 2012 Aesthetic Plast Surg pmid:21964747
Elipenahli C et al. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. 2012 J. Alzheimers Dis. pmid:21971408
Lee BJ et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. 2012 Nutrition pmid:21996047
Xia F et al. Preparation of coenzyme Q10 liposomes using supercritical anti-solvent technique. 2012 J Microencapsul pmid:22034954
Horvath R et al. Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. 2012 J. Neurol. Neurosurg. Psychiatr. pmid:22036850
Kaya Y et al. Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease. 2012 Int J Med Sci pmid:23055813
Ylikallio E and Suomalainen A Mechanisms of mitochondrial diseases. 2012 Ann. Med. pmid:21806499
Terracciano A et al. The use of muscle biopsy in the diagnosis of undefined ataxia with cerebellar atrophy in children. 2012 Eur. J. Paediatr. Neurol. pmid:21873089
Qu RB et al. [Effects of atorvastatin and CoQ(10) on myocardial energy metabolism in rabbits with hypercholesterolemia]. 2012 Zhonghua Yi Xue Za Zhi pmid:22944239
Trimarco V et al. Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension. 2012 High Blood Press Cardiovasc Prev pmid:22994579
Kelekçi S et al. The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ 10) in children with pandemic influenza (H 1 N1) and seasonal flu. 2012 Eur Rev Med Pharmacol Sci pmid:22913153
Bloomer RJ et al. Impact of oral ubiquinol on blood oxidative stress and exercise performance. 2012 Oxid Med Cell Longev pmid:22966414
Fouad AA and Jresat I Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. 2012 Environ. Toxicol. Pharmacol. pmid:22222558
Wang J et al. Physicochemical characterization, photo-stability and cytotoxicity of coenzyme Q10-loading nanostructured lipid carrier. 2012 J Nanosci Nanotechnol pmid:22755031
Hwang TL et al. Magnesium ascorbyl phosphate and coenzyme Q10 protect keratinocytes against UVA irradiation by suppressing glutathione depletion. 2012 Mol Med Rep pmid:22664777
Kumar N et al. Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult? 2012 BMC Gastroenterol pmid:22639867
Karakukcu C et al. Coenzyme Q10 levels in β-thalassemia and its association with ferritin levels and chelation therapy. 2012 Hemoglobin pmid:22483337
Cocchi MN et al. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. 2012 Resuscitation pmid:22465806
Takahashi M et al. Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10. 2012 Exp. Gerontol. pmid:22465812
Takahashi R et al. Coenzyme Q10 therapy in hereditary motor sensory neuropathy type VI with novel mitofusin 2 mutation. 2012 Intern. Med. pmid:22466841
Forester BP et al. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. 2012 J Geriatr Psychiatry Neurol pmid:22467846
Huynh K et al. Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. 2012 Diabetologia pmid:22374176
De la Mata M et al. Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q10. 2012 Neurotherapeutics pmid:22354625
Gorgone G et al. Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson's disease patients. 2012 Neuromolecular Med. pmid:22354693
Quinzii CM et al. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. 2012 PLoS ONE pmid:22359546
Gvozdjakova A et al. Ratio of lipid parameters to coenzyme Q10 could be used as biomarker of the development of early complications of obesity in children. 2012 Bratisl Lek Listy pmid:22380497
Kulakova SN et al. [Effect of coenzyme Q10 supplementation on apoptosis, free radical oxidative processes and proteome pool of microsomal and cytosol fractions of hepatocytes using food ration with different lipid component]. 2012 Vopr Pitan pmid:23461174
Otocka-Kmiecik A et al. [Prodiabetic effect of statins--do we know the mechanisms of this phenomenon?]. 2012 Postepy Biochem. pmid:23214143