Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Zhou S and Chan E Effect of ubidecarenone on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. 2001 Drug Metabol Drug Interact pmid:11460879
Strong MJ and Pattee GL Creatine and coenzyme Q10 in the treatment of ALS. 2000 Amyotroph. Lateral Scler. Other Motor Neuron Disord. pmid:11466954
Xiong D et al. [Experimental study on treatment of viral myocarditis in mice by integrated traditional Chinese and Western Medicine]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11477833
Wang S et al. [Effect on life span and membrane protein in red blood cells by integrated medicine therapy on chronic aplastic anemia]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11477920
Bleske BE et al. The effect of pravastatin and atorvastatin on coenzyme Q10. 2001 Am. Heart J. pmid:11479481
Thünemann AF and General S Nanoparticles of a polyelectrolyte-fatty acid complex: carriers for Q10 and triiodothyronine. 2001 J Control Release pmid:11489312
Battino M et al. Coenzymes Q9 and Q10, vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing. 2001 Biol. Chem. pmid:11501757
Palmeira CM et al. Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: role of coenzyme Q. 2001 Am. J. Physiol., Cell Physiol. pmid:11502580
Shults CW and Schapira AH A cue to queue for CoQ? 2001 Neurology pmid:11502896
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. 2001 Neurology pmid:11502903
Di Giovanni S et al. Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency. 2001 Neurology pmid:11502923
Westesen K et al. Novel colloidal drug delivery systems. 2001 Jul-Aug PDA J Pharm Sci Technol pmid:11505557
Timoshin AA et al. [Free radical centers in the dog myocardial tissue in regional ischemia]. 2001 Jul-Aug Biofizika pmid:11558387
Rahman S et al. Neonatal presentation of coenzyme Q10 deficiency. 2001 J. Pediatr. pmid:11562630
Extra co-enzyme Q10 for statin-users? 2001 TreatmentUpdate pmid:11570288
Genova ML et al. The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2. 2001 FEBS Lett. pmid:11576529
Murakami N [Mitochondrial diseases with recurrent myoglobinuria]. 2001 Ryoikibetsu Shokogun Shirizu pmid:11596365
Takusa Y and Yamaguchi S [Myopathies with miscellaneous disorders related to mitochondrial fatty acid oxidation: defective synthesis of ketone body, long-chain fatty acid transport defect, and muscular coenzyme Q10 deficiency]. 2001 Ryoikibetsu Shokogun Shirizu pmid:11596461
Murad N et al. Coenzyme Q10 exogenous administration attenuates cold stress cardiac injury. 2001 Jpn Heart J pmid:11605771
Yano T and Ohnishi T The origin of cluster N2 of the energy-transducing NADH-quinone oxidoreductase: comparisons of phylogenetically related enzymes. 2001 J. Bioenerg. Biomembr. pmid:11695831
Geromel V et al. Human cultured skin fibroblasts survive profound inherited ubiquinone depletion. 2001 Free Radic. Res. pmid:11697113
Vavrínková H et al. The effect of captopril on nitric oxide formation and on generation of radical forms of mitochondrial respiratory chain compounds in ischemic rat heart. 2001 Physiol Res pmid:11702852
Lyon W et al. Similar therapeutic serum levels attained with emulsified and oil-based preparations of coenzyme Q10. 2001 Asia Pac J Clin Nutr pmid:11708311
Schilling G et al. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model. 2001 Neurosci. Lett. pmid:11716985
Siciliano G et al. Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystrophy. 2001 Oct-Nov 1 Brain Res. Bull. pmid:11719279
Sinatra ST Alternative medicine for the conventional cardiologist. 2000 Jan-Feb Heart Dis pmid:11728240
Krone CA et al. Does gastrointestinal Candida albicans prevent ubiquinone absorption? 2001 Med. Hypotheses pmid:11735312
Cornelli U et al. Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress. 2001 J. Nutr. pmid:11739867
Robles R et al. Oxidative stress in the neonate. 2001 Early Hum. Dev. pmid:11755038
Arroyo A et al. Interactions between ascorbyl free radical and coenzyme Q at the plasma membrane. 2000 J. Bioenerg. Biomembr. pmid:11768753
Grudziński IP and Frankiewicz-Jóźko A Effects of oral coenzyme Q10 supplementation on sodium nitrite-induced lipid peroxidation in rats. 2001 Rocz Panstw Zakl Hig pmid:11771113
Crane FL Biochemical functions of coenzyme Q10. 2001 J Am Coll Nutr pmid:11771674
Burke BE et al. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. 2001 South. Med. J. pmid:11780680
Crestanello JA et al. Effect of coenzyme Q10 supplementation on mitochondrial function after myocardial ischemia reperfusion. 2002 J. Surg. Res. pmid:11796022
Hughes K et al. Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese. 2002 Free Radic. Biol. Med. pmid:11796201
Nazzal S et al. Preparation and characterization of coenzyme Q10-Eudragit solid dispersion. 2002 Drug Dev Ind Pharm pmid:11858524
Hargreaves IP and Heales S Statins and myopathy. 2002 Lancet pmid:11879898
Tang PH et al. Anticoagulant effects on plasma coenzyme Q(10) estimated by HPLC with coulometric detection. 2002 Clin. Chim. Acta pmid:11880122
Ferrante RJ et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. 2002 J. Neurosci. pmid:11880489
Tommasini I et al. Delayed formation of hydrogen peroxide mediates the lethal response evoked by peroxynitrite in U937 cells. 2002 Mol. Pharmacol. pmid:11901226
Bliznakov EG Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case--a modern Pandora's box. 2002 Biomed. Pharmacother. pmid:11905511
Ducci M et al. Coenzyme Q10 levels in pigeon (Columba livia) spermatozoa. 2002 Asian J. Androl. pmid:11907632
Watts GF et al. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. 2002 Diabetologia pmid:11914748
Yoon HR et al. Therapeutic trial in the first three Asian cases of ethylmalonic encephalopathy: response to riboflavin. 2001 J. Inherit. Metab. Dis. pmid:11916321
Chagan L et al. Use of alternative pharmacotherapy in management of cardiovascular diseases. 2002 Am J Manag Care pmid:11924555
Brancato R et al. Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits. 2002 Mar-Apr J Refract Surg pmid:11934201
Colomé C et al. Ubiquinone-10 content in lymphocytes of phenylketonuric patients. 2002 Clin. Biochem. pmid:11937084
Huang CC et al. Rapid visual recovery after coenzyme q10 treatment of leber hereditary optic neuropathy. 2002 J Neuroophthalmol pmid:11937918
Mosca L et al. Modulation of apoptosis and improved redox metabolism with the use of a new antioxidant formula. 2002 Biochem. Pharmacol. pmid:11960607
Balercia G et al. Coenzyme Q10 levels in idiopathic and varicocele-associated asthenozoospermia. 2002 Andrologia pmid:11966577