Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
DiNicolantonio JJ CoQ10 and L-carnitine for statin myalgia? 2012 Expert Rev Cardiovasc Ther pmid:23190071
Lee BJ et al. A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease. 2012 Nutr Res pmid:23146771
Marotta F et al. Biomarine extracts significantly protect from ultraviolet A-induced skin photoaging: an ex vivo study. 2012 Rejuvenation Res pmid:22533422
Lulli M et al. Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. 2012 Invest. Ophthalmol. Vis. Sci. pmid:23154463
Park J et al. Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals. 2012 Brain Res. pmid:23046589
Mikhin VP et al. [Efficacy of the use of coenzyme q10 at the background of traditional therapy of chronic ischemic heart disease]. 2012 Kardiologiia pmid:23098344
Gokce M et al. Antioxidant vitamins C, E and coenzyme Q10 vs dexamethasone: comparisons of their effects in pulmonary contusion model. 2012 J Cardiothorac Surg pmid:23013526
Martin E et al. Hydrogen bonding between the Q(B) site ubisemiquinone and Ser-L223 in the bacterial reaction center: a combined spectroscopic and computational perspective. 2012 Biochemistry pmid:23016832
Gendelman M and Roth Z Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. 2012 Biol. Reprod. pmid:23018185
Pastore A et al. Pediatric reference intervals for muscle coenzyme Q(10). 2012 Biomarkers pmid:23020092
Stacpoole PW et al. Design and implementation of the first randomized controlled trial of coenzyme CoQ₁₀ in children with primary mitochondrial diseases. 2012 Mitochondrion pmid:23022402
Markley HG CoEnzyme Q10 and riboflavin: the mitochondrial connection. 2012 Headache pmid:23030537
Mancini A et al. Relationship between plasma antioxidants and thyroid hormones in chronic obstructive pulmonary disease. 2012 Exp. Clin. Endocrinol. Diabetes pmid:23073919
Vrzhesinskaia OA et al. [The effect of fatty component of diet and coenzyme Q10 on rat sufficiency with vitamins-antioxidans in chronic experiments]. 2012 Vopr Pitan pmid:23530435
Tiano L et al. Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation. 2012 Neurobiol. Aging pmid:21601315
Yoon JH et al. Marivita hallyeonensis sp. nov., isolated from seawater, reclassification of Gaetbulicola byunsanensis as Marivita byunsanensis comb. nov. and emended description of the genus Marivita Hwang et al. 2009. 2012 Int. J. Syst. Evol. Microbiol. pmid:21602362
Liu J et al. WITHDRAWN: Coenzyme Q10 for Parkinson's disease. 2012 Cochrane Database Syst Rev pmid:22592726
Bookstaver DA et al. Effect of coenzyme Q10 supplementation on statin-induced myalgias. 2012 Am. J. Cardiol. pmid:22608359
Aalbers J Coenzyme Q10, an anti-oxidant of value to reduce oxidative stress; also useful to reduce statin-induced myalgia. 2012 Cardiovasc J Afr pmid:22555643
Perez-Sanchez C et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment. 2012 Blood pmid:22529290
Cordero MD et al. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. 2012 PLoS ONE pmid:22532869
Marotta F et al. Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging. 2012 Rejuvenation Res pmid:22533426
Schmelzer C and Döring F Micronutrient special issue: coenzyme Q(10) requirements for DNA damage prevention. 2012 Mutat. Res. pmid:21964355
Keck M et al. Coenzyme Q10 does not enhance preadipocyte viability in an in vitro lipotransfer model. 2012 Aesthetic Plast Surg pmid:21964747
Elipenahli C et al. Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice. 2012 J. Alzheimers Dis. pmid:21971408
Binukumar BK et al. Protective efficacy of coenzyme Q10 against DDVP-induced cognitive impairments and neurodegeneration in rats. 2012 Neurotox Res pmid:22083459
Tazato N et al. Gluconacetobacter tumulicola sp. nov. and Gluconacetobacter asukensis sp. nov., isolated from the stone chamber interior of the Kitora Tumulus. 2012 Int. J. Syst. Evol. Microbiol. pmid:22038998
Lee BJ et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. 2012 Nutrition pmid:21996047
Hickey MA et al. Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease. 2012 Mol. Cell. Neurosci. pmid:22044764
Xia F et al. Preparation of coenzyme Q10 liposomes using supercritical anti-solvent technique. 2012 J Microencapsul pmid:22034954
Horvath R et al. Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. 2012 J. Neurol. Neurosurg. Psychiatr. pmid:22036850
Lin HZ et al. Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. 2012 Kaohsiung J. Med. Sci. pmid:23217361
Díaz-Castro J et al. Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise. 2012 Eur J Nutr pmid:21990004
Zlatohlavek L et al. The effect of coenzyme Q10 in statin myopathy. 2012 Neuro Endocrinol. Lett. pmid:23183519
Gokce EH et al. A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers. 2012 Int J Nanomedicine pmid:23055723
Jung YT et al. Erythrobacter marinus sp. nov., isolated from seawater. 2012 Int. J. Syst. Evol. Microbiol. pmid:22021578
Kaya Y et al. Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease. 2012 Int J Med Sci pmid:23055813
Ylikallio E and Suomalainen A Mechanisms of mitochondrial diseases. 2012 Ann. Med. pmid:21806499
Terracciano A et al. The use of muscle biopsy in the diagnosis of undefined ataxia with cerebellar atrophy in children. 2012 Eur. J. Paediatr. Neurol. pmid:21873089
Felippi CC et al. Safety and efficacy of antioxidants-loaded nanoparticles for an anti-aging application. 2012 J Biomed Nanotechnol pmid:22515083
Zhang M et al. Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro. 2012 Int J Cosmet Sci pmid:22339577
Bravo E et al. Coenzyme Q metabolism is disturbed in high fat diet-induced non-alcoholic fatty liver disease in rats. 2012 Int J Mol Sci pmid:22408414
Lee BJ et al. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. 2012 Nutrition pmid:22342390
Cordero MD et al. Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. 2012 Clin. Biochem. pmid:22342824
Biglan KM et al. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. 2012 J Huntingtons Dis pmid:25063191
Moon HJ et al. Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. 2012 Biochem. Biophys. Res. Commun. pmid:22252298
Manya K et al. The use of complementary and alternative medicine among people living with diabetes in Sydney. 2012 BMC Complement Altern Med pmid:22240113
Qu RB et al. [Effects of atorvastatin and CoQ(10) on myocardial energy metabolism in rabbits with hypercholesterolemia]. 2012 Zhonghua Yi Xue Za Zhi pmid:22944239
Trimarco V et al. Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension. 2012 High Blood Press Cardiovasc Prev pmid:22994579
Kelekçi S et al. The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ 10) in children with pandemic influenza (H 1 N1) and seasonal flu. 2012 Eur Rev Med Pharmacol Sci pmid:22913153
Pfeffer G et al. Treatment for mitochondrial disorders. 2012 Cochrane Database Syst Rev pmid:22513923
Rahman S et al. 176th ENMC International Workshop: diagnosis and treatment of coenzyme Q₁₀ deficiency. 2012 Neuromuscul. Disord. pmid:21723727
Bloomer RJ et al. Impact of oral ubiquinol on blood oxidative stress and exercise performance. 2012 Oxid Med Cell Longev pmid:22966414
Fouad AA and Jresat I Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. 2012 Environ. Toxicol. Pharmacol. pmid:22222558
Qiu L et al. Coenzyme Q(10) production by immobilized Sphingomonas sp. ZUTE03 via a conversion-extraction coupled process in a three-phase fluidized bed reactor. 2012 Enzyme Microb. Technol. pmid:22226200
Young JM et al. Pharmacokinetic comparison of a generic coenzyme Q₁₀ solubilizate and a formulation with soybean phytosterols. 2012 Phytother Res pmid:22228560
García-Rodríguez CE et al. Does consumption of two portions of salmon per week enhance the antioxidant defense system in pregnant women? 2012 Antioxid. Redox Signal. pmid:22229304
Cascella V et al. A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss. 2012 Med. Sci. Monit. pmid:22207104
Milano F et al. Enhancing the light harvesting capability of a photosynthetic reaction center by a tailored molecular fluorophore. 2012 Angew. Chem. Int. Ed. Engl. pmid:23011764
Koziel A et al. The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells. 2012 Pflugers Arch. pmid:23053476
Okudan N et al. Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart. 2012 Bratisl Lek Listy pmid:22794511
Russo V et al. Early onset "electrical" heart failure in myotonic dystrophy type 1 patient: the role of ICD biventricular pacing. 2012 Anadolu Kardiyol Derg pmid:22728727
Belhaj N et al. Formulation, characterization and pharmacokinetic studies of coenzyme Q₁₀ PUFA's nanoemulsions. 2012 Eur J Pharm Sci pmid:22732255
Sutachan JJ et al. Cellular and molecular mechanisms of antioxidants in Parkinson's disease. 2012 Nutr Neurosci pmid:22732354
Rasmussen CB et al. Dietary supplements and hypertension: potential benefits and precautions. 2012 J Clin Hypertens (Greenwich) pmid:22747620
Garrido-Maraver J et al. Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease. 2012 Br. J. Pharmacol. pmid:22747838
Wang J et al. Physicochemical characterization, photo-stability and cytotoxicity of coenzyme Q10-loading nanostructured lipid carrier. 2012 J Nanosci Nanotechnol pmid:22755031
Hwang TL et al. Magnesium ascorbyl phosphate and coenzyme Q10 protect keratinocytes against UVA irradiation by suppressing glutathione depletion. 2012 Mol Med Rep pmid:22664777
Kumar N et al. Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult? 2012 BMC Gastroenterol pmid:22639867
Karakukcu C et al. Coenzyme Q10 levels in β-thalassemia and its association with ferritin levels and chelation therapy. 2012 Hemoglobin pmid:22483337
Cocchi MN et al. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. 2012 Resuscitation pmid:22465806
Takahashi M et al. Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10. 2012 Exp. Gerontol. pmid:22465812
Takahashi R et al. Coenzyme Q10 therapy in hereditary motor sensory neuropathy type VI with novel mitofusin 2 mutation. 2012 Intern. Med. pmid:22466841
Forester BP et al. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. 2012 J Geriatr Psychiatry Neurol pmid:22467846
Okudan N et al. Effects of treatment with coenzyme Q10 on exercised rat aorta. 2012 Acta Physiol Hung pmid:22425807
Onoue S et al. Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors. 2012 Eur J Pharm Sci pmid:22498005
Mehmetoglu I et al. Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. 2012 Int J Artif Organs pmid:22461118
Fetoni AR et al. Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: systemic versus transtympanic modality. 2012 Acta Otolaryngol. pmid:22443854
Salviati L et al. Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. 2012 J. Med. Genet. pmid:22368301
Chirapapaisan N et al. The effect of coenzyme Q10 and curcumin on chronic methanol intoxication induced retinopathy in rats. 2012 J Med Assoc Thai pmid:22696856
Matsubara A et al. High-accuracy analysis system for the redox status of coenzyme Q10 by online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry. 2012 J Chromatogr A pmid:22673808
Damian MS and Hargreaves I Ubiquinone in cardiac arrest: from bathroom to bedside. 2012 Resuscitation pmid:22640977
Lee BJ et al. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. 2012 ScientificWorldJournal pmid:22645453
Muraki A et al. Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. 2012 J. Appl. Physiol. pmid:22653988
Huynh K et al. Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. 2012 Diabetologia pmid:22374176
Galasko DR et al. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. 2012 Arch. Neurol. pmid:22431837
De la Mata M et al. Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q10. 2012 Neurotherapeutics pmid:22354625
Gorgone G et al. Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson's disease patients. 2012 Neuromolecular Med. pmid:22354693
Quinzii CM et al. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. 2012 PLoS ONE pmid:22359546
Gvozdjakova A et al. Ratio of lipid parameters to coenzyme Q10 could be used as biomarker of the development of early complications of obesity in children. 2012 Bratisl Lek Listy pmid:22380497
Yubero-Serrano EM et al. Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women. 2012 J. Gerontol. A Biol. Sci. Med. Sci. pmid:22016358
Piepel G et al. Mixture-process variable approach to optimize a microemulsion electrokinetic chromatography method for the quality control of a nutraceutical based on coenzyme Q10. 2012 Talanta pmid:22841049
Vidyashankar S et al. Alcohol depletes coenzyme-Q(10) associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells. 2012 Toxicology pmid:22841563
Lulli M et al. Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo. 2012 J. Radiat. Res. pmid:22843363
Kulakova SN et al. [Effect of coenzyme Q10 supplementation on apoptosis, free radical oxidative processes and proteome pool of microsomal and cytosol fractions of hepatocytes using food ration with different lipid component]. 2012 Vopr Pitan pmid:23461174
Otocka-Kmiecik A et al. [Prodiabetic effect of statins--do we know the mechanisms of this phenomenon?]. 2012 Postepy Biochem. pmid:23214143
Deichmann RE et al. Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins. 2012 Phys Sportsmed pmid:23306418
Gutierrez-Mariscal FM et al. Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects. 2012 Age (Dordr) pmid:21404051
Bergamini C et al. A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells. 2012 PLoS ONE pmid:22432044
Seo MJ et al. Association of colony morphology with coenzyme Q(10) production and its enhancement from Rhizobium radiobacter T6102W by addition of isopentenyl alcohol as a precursor. 2012 J. Microbiol. Biotechnol. pmid:22370354