Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Macunluoglu B et al. Serum coenzyme Q10 levels are associated with coronary flow reserve in hemodialysis patients. 2013 Hemodial Int pmid:23185999
Codoñer-Franch P et al. Diet supplementation during early lactation with non-alcoholic beer increases the antioxidant properties of breastmilk and decreases the oxidative damage in breastfeeding mothers. 2013 Breastfeed Med pmid:23186386
Baluchnejadmojarad T and Roghani M Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat. 2013 J. Mol. Neurosci. pmid:23008120
Tsubouchi T et al. Brevundimonas abyssalis sp. nov., a dimorphic prosthecate bacterium isolated from deep-subsea floor sediment. 2013 Int. J. Syst. Evol. Microbiol. pmid:23041635
Zheng WT et al. Mesorhizobium qingshengii sp. nov., isolated from effective nodules of Astragalus sinicus. 2013 Int. J. Syst. Evol. Microbiol. pmid:23041644
Krim SR et al. Micronutrients in chronic heart failure. 2013 Curr Heart Fail Rep pmid:23070580
Salama M et al. Co-enzyme Q10 to treat neurological disorders: basic mechanisms, clinical outcomes, and future research direction. 2013 CNS Neurol Disord Drug Targets pmid:23574157
Moon HJ et al. Coenzyme q10 regulates osteoclast and osteoblast differentiation. 2013 J. Food Sci. pmid:23582186
Montero R et al. Coenzyme Q₁₀ deficiency in mitochondrial DNA depletion syndromes. 2013 Mitochondrion pmid:23583954
Haorah J et al. Reduction of brain mitochondrial β-oxidation impairs complex I and V in chronic alcohol intake: the underlying mechanism for neurodegeneration. 2013 PLoS ONE pmid:23967116
Johansson P et al. Effect of selenium and Q10 on the cardiac biomarker NT-proBNP. 2013 Scand. Cardiovasc. J. pmid:23895165
Schallreuter KU Q10-triggered facial vitiligo. 2013 Br. J. Dermatol. pmid:23952052
Pfeffer G and Chinnery PF Diagnosis and treatment of mitochondrial myopathies. 2013 Ann. Med. pmid:21867371
Ivanov AV et al. Single intravenous injection of coenzyme Q10 protects the myocardium after irreversible ischemia. 2013 Bull. Exp. Biol. Med. pmid:24288763
Gvozdjakova A et al. Importance of the assessment of coenzyme Q10, alpha-tocopherol and oxidative stress for the diagnosis and therapy of infertility in men. 2013 Bratisl Lek Listy pmid:24236426
Sato Y et al. Emulsification using highly hydrophilic surfactants improves the absorption of orally administered coenzyme Q10. 2013 Biol. Pharm. Bull. pmid:24292061
Malaga-Dieguez L and Susztak K ADCK4 "reenergizes" nephrotic syndrome. 2013 J. Clin. Invest. pmid:24270414
Marušić N et al. Nutritional pork meat compounds as affected by ham dry-curing. 2013 Meat Sci. pmid:22910804
Zhu C et al. Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies. 2013 Plant Biotechnol. J. pmid:22970850
Park S and Yoon JH Hirschia litorea sp. nov., isolated from seashore sediment, and emended description of the genus Hirschia. 2013 Int. J. Syst. Evol. Microbiol. pmid:22904229
Larijani VN et al. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. 2013 Nutrition pmid:22858191
Coppadoro A et al. Critical illness is associated with decreased plasma levels of coenzyme Q10: a cross-sectional study. 2013 J Crit Care pmid:23618779
Shetty RA et al. Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation. 2013 Age (Dordr) pmid:23138632
Duberley KE et al. Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. 2013 J. Inherit. Metab. Dis. pmid:22767283
Xie F et al. [Research of the relationship of ubiquinone and beclin-1 and liver mitochondria]. 2013 Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi pmid:24579466
Lafuente R et al. Coenzyme Q10 and male infertility: a meta-analysis. 2013 J. Assist. Reprod. Genet. pmid:23912751
Lee BJ et al. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. 2013 Nutr J pmid:24192015
First drug to improve heart failure mortality in over a decade: coenzyme Q10 decreases all-cause mortality by half in randomized double blind trial. 2013 Eur. Heart J. pmid:24137722
Yoon JH et al. Loktanella litorea sp. nov., isolated from seawater. 2013 Int. J. Syst. Evol. Microbiol. pmid:22389278
da Silva Machado C et al. Coenzyme Q10 protects Pc12 cells from cisplatin-induced DNA damage and neurotoxicity. 2013 Neurotoxicology pmid:23434506
Schwarz JC et al. Ultra-small NLC for improved dermal delivery of coenyzme Q10. 2013 Int J Pharm pmid:23438979
Nguyen T et al. In adults with reduced left ventricular ejection fractions (systolic heart failure), does coenzyme Q10 improve cardiac function or patient outcomes? 2013 J Okla State Med Assoc pmid:23505780
Fash DM et al. Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection. 2013 Bioorg. Med. Chem. pmid:23473946
Tani A and Sahin N Methylobacterium haplocladii sp. nov. and Methylobacterium brachythecii sp. nov., isolated from bryophytes. 2013 Int. J. Syst. Evol. Microbiol. pmid:23475343
Gaboyer F et al. Phaeobacter leonis sp. nov., an alphaproteobacterium from Mediterranean Sea sediments. 2013 Int. J. Syst. Evol. Microbiol. pmid:23475346
Nishijima M et al. Gluconacetobacter tumulisoli sp. nov., Gluconacetobacter takamatsuzukensis sp. nov. and Gluconacetobacter aggeris sp. nov., isolated from Takamatsuzuka Tumulus samples before and during the dismantling work in 2007. 2013 Int. J. Syst. Evol. Microbiol. pmid:23793855
Kolahdouz Mohammadi R et al. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. 2013 Minerva Gastroenterol Dietol pmid:23831913
Fu R et al. Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1. 2013 Hum. Mol. Genet. pmid:23666527
Kämpfer P et al. Ruegeria intermedia sp. nov., a moderately thermophilic bacterium isolated from a coastal hot spring. 2013 Int. J. Syst. Evol. Microbiol. pmid:23243093
Jin L et al. Caulobacter daechungensis sp. nov., a stalked bacterium isolated from a eutrophic reservoir. 2013 Int. J. Syst. Evol. Microbiol. pmid:23243096
Larsen S et al. Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. 2013 J. Am. Coll. Cardiol. pmid:23287371
Fotino AD et al. Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. 2013 Am. J. Clin. Nutr. pmid:23221577
Xi XD et al. Taonella mepensis gen. nov., sp. nov., a member of the family Rhodospirillaceae isolated from activated sludge. 2013 Int. J. Syst. Evol. Microbiol. pmid:23223814
Lin SY et al. Aureimonas ferruginea sp. nov. and Aureimonas rubiginis sp. nov., two siderophore-producing bacteria isolated from rusty iron plates. 2013 Int. J. Syst. Evol. Microbiol. pmid:23203620
Turdahon M et al. Rhizobium tarimense sp. nov., isolated from soil in the ancient Khiyik River. 2013 Int. J. Syst. Evol. Microbiol. pmid:23203621
Stocker R and Macdonald P The benefit of coenzyme Q10 supplements in the management of chronic heart failure: a long tale of promise in the continued absence of clear evidence. 2013 Am. J. Clin. Nutr. pmid:23325068
Turk S et al. Coenzyme Q10 supplementation and diastolic heart functions in hemodialysis patients: a randomized double-blind placebo-controlled trial. 2013 Hemodial Int pmid:23360359
Kerr DS Review of clinical trials for mitochondrial disorders: 1997-2012. 2013 Neurotherapeutics pmid:23361264
Mugoni V et al. Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. 2013 Cell pmid:23374346
Aboul-Fotouh S Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. 2013 Pharmacol. Biochem. Behav. pmid:23313551