Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Gendelman M and Roth Z Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. 2012 Biol. Reprod. pmid:23018185
Perez-Sanchez C et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment. 2012 Blood pmid:22529290
Lin HZ et al. Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy. 2012 Kaohsiung J. Med. Sci. pmid:23217361
Manya K et al. The use of complementary and alternative medicine among people living with diabetes in Sydney. 2012 BMC Complement Altern Med pmid:22240113
Sutachan JJ et al. Cellular and molecular mechanisms of antioxidants in Parkinson's disease. 2012 Nutr Neurosci pmid:22732354
Lee BJ et al. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. 2012 ScientificWorldJournal pmid:22645453
Yen HC et al. Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q(10) in human cells. 2011 Sep-Oct J. Biochem. Mol. Toxicol. pmid:21308897
Tiano L and Busciglio J Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ? 2011 Sep-Oct Biofactors pmid:22009852
Mancini A and Balercia G Coenzyme Q(10) in male infertility: physiopathology and therapy. 2011 Sep-Oct Biofactors pmid:21989906
Blatt T and Littarru GP Biochemical rationale and experimental data on the antiaging properties of CoQ(10) at skin level. 2011 Sep-Oct Biofactors pmid:21990001
Quinzii CM and Hirano M Primary and secondary CoQ(10) deficiencies in humans. 2011 Sep-Oct Biofactors pmid:21990098
Cordero MD [Oxidative stress in fibromyalgia: pathophysiology and clinical implications]. 2011 Sep-Oct Reumatol Clin pmid:21925443
Littarru GP et al. Coenzyme Q(10) , endothelial function, and cardiovascular disease. 2011 Sep-Oct Biofactors pmid:21674640
Sikka P et al. Statin intolerance: now a solved problem. 2011 Oct-Dec J Postgrad Med pmid:22120862
Shilov AM et al. [Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme]. 2011 Mar-Apr Anesteziol Reanimatol pmid:21692219
Sensini M et al. [Coenzyme Q10 (Q-ter) in treatment of functional voice disorders]. 2011 Jul-Sep G Ital Med Lav Ergon pmid:23393879
Lee JH et al. Nutritional assessment in heart failure patients. 2011 Jul-Aug Congest Heart Fail pmid:21790970
Anbarasan D et al. Drug-induced leukoencephalopathy presenting as catatonia. 2011 Jan-Feb Gen Hosp Psychiatry pmid:21353145
Ross SM Clinical applications of integrative therapies for prevention and treatment of migraine headaches. 2011 Jan-Feb Holist Nurs Pract pmid:21150505
Sivak LA et al. [Cardiotoxicity of conservative treatment of solid tumors]. 2011 Apr-Jun Lik. Sprava pmid:22416364
Cordero MD et al. Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. 2011 Mitochondrion pmid:21496502
Cheng W et al. Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity. 2011 Int. J. Immunogenet. pmid:21518260
Ahmed M et al. Coenzyme q10 and creatine in heart failure: micronutrients, macrobenefit? 2011 Clin Cardiol pmid:21462213
Fumagalli S et al. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. 2011 Clin Cardiol pmid:21462215
Castellotti B et al. Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients. 2011 Neurogenetics pmid:21465257
Cooney RV et al. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21467235
Gironi M et al. Oxidative imbalance in different neurodegenerative diseases with memory impairment. 2011 Neurodegener Dis pmid:20838029
Zhong W et al. Coenzyme Q(10) production directly from precursors by free and gel-entrapped Sphingomonas sp. ZUTE03 in a water-organic solvent, two-phase conversion system. 2011 Appl. Microbiol. Biotechnol. pmid:20857286
Wójcicka G et al. Differential effects of statins on endogenous H2S formation in perivascular adipose tissue. 2011 Pharmacol. Res. pmid:20969959
Wang S et al. Protective effect of Coenzyme Q(10) against oxidative damage in human lens epithelial cells by novel ocular drug carriers. 2011 Int J Pharm pmid:20971176
Ishikawa A et al. Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. 2011 Clin. Exp. Nephrol. pmid:20878200
Avis HJ et al. Rosuvastatin lowers coenzyme Q10 levels, but not mitochondrial adenosine triphosphate synthesis, in children with familial hypercholesterolemia. 2011 J. Pediatr. pmid:20884007
Chai W et al. Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21297042
Yuan B et al. Validated HPLC method for the quantitative determination of CoQ(10) in dog plasma and its application to a pharmacokinetic study. 2011 Biomed. Chromatogr. pmid:21154890
Yubero-Serrano EM et al. Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. 2011 Age (Dordr) pmid:21170684
Tanrikulu AC et al. Coenzyme Q10, copper, zinc, and lipid peroxidation levels in serum of patients with chronic obstructive pulmonary disease. 2011 Biol Trace Elem Res pmid:21080098
Karadas F et al. Changes in broiler chick tissue concentrations of lipid-soluble antioxidants immediately post-hatch. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21605692
Fragaki K et al. Fatal heart failure associated with CoQ10 and multiple OXPHOS deficiency in a child with propionic acidemia. 2011 Mitochondrion pmid:21329767
Nielsen ML et al. [Reduced synthesis of coenzyme Q10 may cause statin related myopathy]. 2011 Ugeskr. Laeg. pmid:22094213
Garjani A et al. Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. 2011 Eur. J. Pharmacol. pmid:21570962
Guo J et al. [Effects of milk and coenzyme Q10 on the interference of acrylonitrile on vascular endothelial functions]. 2011 Zhonghua Yi Xue Za Zhi pmid:21609600
Terán E et al. Maternal plasma and amniotic fluid coenzyme Q10 levels in preterm and term gestations: a pilot study. 2011 Arch. Gynecol. Obstet. pmid:21547699
Cotán D et al. Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts. 2011 FASEB J. pmid:21551238
Slater SK et al. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. 2011 Cephalalgia pmid:21586650
Cobanoglu U et al. Lipid peroxidation, DNA damage and coenzyme Q10 in lung cancer patients--markers for risk assessment? 2011 Asian Pac. J. Cancer Prev. pmid:22126471
Venegas C et al. Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. 2011 J. Agric. Food Chem. pmid:22007968
Tawfik MK Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. 2011 Epilepsy Behav pmid:22036465
Michalkiewicz S Anodic oxidation of oxidized forms of coenzymes Q(10) and Q(0) on carbon electrodes in acetic acid solutions. 2011 Bioelectrochemistry pmid:21741327
Potgieter M et al. Histological assessment of SJL/J mice treated with the antioxidants coenzyme Q10 and resveratrol. 2011 Micron pmid:21036052
Staicu ML et al. Effects of exogenous antioxidants on oxidative stress in pregnancy. 2011 J Med Life pmid:21776299
Martin SB et al. Coenzyme Q10 and cognition in atorvastatin treated dogs. 2011 Neurosci. Lett. pmid:21763754
Piao H et al. In vitro-in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals. 2011 Int J Pharm pmid:21803142
Tsai KL et al. Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. 2011 Mol Nutr Food Res pmid:21812107
Gokbel H et al. Coenzyme Q10 and its relation with oxidant and antioxidant system markers in patients with end-stage renal disease. 2011 Ren Fail pmid:21787158
Vasiliev AV et al. Effects of coenzyme Q10 on rat liver cells under conditions of metabolic stress. 2011 Bull. Exp. Biol. Med. pmid:22268031
Boles RG High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. 2011 BMC Neurol pmid:21846334
Won R et al. Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture. 2011 Neuroreport pmid:21849914
Giannubilo SR et al. Plasma coenzyme Q10 is increased during gestational diabetes. 2011 Diabetes Res. Clin. Pract. pmid:21816499
Tang KF et al. [Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia]. 2011 Zhonghua Nan Ke Xue pmid:21823344
Binukumar BK et al. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment. 2011 Toxicol. Appl. Pharmacol. pmid:21843543
Mikhin VP et al. [Application of coenzyme Q(10) in combination therapy of arterial hypertension]. 2011 Kardiologiia pmid:21878067
Samoilova RI et al. Reaction of superoxide radical with quinone molecules. 2011 J Phys Chem A pmid:21910470
Simonenko VB et al. [Myocardial cytoprotectors, a reserve therapeutic modality for patients with stable angina of effort]. 2011 Klin Med (Mosk) pmid:21932560
Dixson DD et al. Recombinant expression of His-tagged saposin B and pH-dependent binding to the lipid coenzyme Q10. 2011 Anal. Biochem. pmid:21933657
Orsucci D et al. Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and its analogues. 2011 Curr. Med. Chem. pmid:21824087
Donnino MW et al. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. 2011 Crit Care pmid:21827677
Liu J et al. Coenzyme Q10 for Parkinson's disease. 2011 Cochrane Database Syst Rev pmid:22161420
Kulakova SN et al. [Effect of fatty component in ration and coenzyme Q10 on indices of rat lipid metabolism in ontogenesis]. 2011 Vopr Pitan pmid:22238945
Sharanova NE et al. Effect of coenzyme Q10 on proteomic profile of rat plasma under conditions of metabolic stress. 2011 Bull. Exp. Biol. Med. pmid:22485206
Golbidi S et al. Antioxidants in the treatment of diabetes. 2011 Curr Diabetes Rev pmid:21294707
de Freitas RM et al. Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures. 2011 Fundam Clin Pharmacol pmid:20584200
Ries V et al. Mitochondrial dysfunction as a therapeutic target in progressive supranuclear palsy. 2011 J. Mol. Neurosci. pmid:21792607
Stacpoole PW Why are there no proven therapies for genetic mitochondrial diseases? 2011 Mitochondrion pmid:21605707
Li HT et al. Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder. 2011 Int Urol Nephrol pmid:20533089
Karagodina ZV et al. [Relationship between changes in peroxide oxidation lipoide index, coenzyme Q10 and free fatty acids by of rats depending of fatty acid component in the ration]. 2011 Vopr Pitan pmid:22379857
Rastogi A and Pospísil P Spontaneous ultraweak photon emission imaging of oxidative metabolic processes in human skin: effect of molecular oxygen and antioxidant defense system. 2011 J Biomed Opt pmid:21950919
Dai YL et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. 2011 Atherosclerosis pmid:21388622
Jung YT et al. Roseovarius marinus sp. nov., isolated from seawater. 2011 Int. J. Syst. Evol. Microbiol. pmid:20348324
Kämpfer P et al. Novosphingobium soli sp. nov., isolated from soil. 2011 Int. J. Syst. Evol. Microbiol. pmid:20207802
Qiu L et al. Coenzyme Q10 production by Sphingomonas sp. ZUTE03 with novel precursors isolated from tobacco waste in a two-phase conversion system. 2011 J. Microbiol. Biotechnol. pmid:21617346
Tiano L et al. Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial. 2011 Neurobiol. Aging pmid:20022408
Miles MV et al. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. 2011 Mitochondrion pmid:20817046
Tran TP et al. Tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal muscles: Involvement of superoxide. 2011 Eur. J. Pharmacol. pmid:21036124
Spurney CF et al. CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophy. 2011 Muscle Nerve pmid:21698649
Sagel SD et al. Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. 2011 J. Cyst. Fibros. pmid:20961818
Swarnakar NK et al. Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. 2011 Biomaterials pmid:21704368
Dixson DD et al. Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii. 2011 Chem. Biodivers. pmid:21674778
Gül I et al. Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. 2011 J Sports Med Phys Fitness pmid:21681167
Nik AM et al. Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions. 2011 Mol Nutr Food Res pmid:21638776
Chen CC et al. Coenzyme Q10 reduces ethanol-induced apoptosis in corneal fibroblasts. 2011 PLoS ONE pmid:21556371
Young JM et al. Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. 2011 Atherosclerosis pmid:21640350
Shojaei M et al. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. 2011 Iran J Kidney Dis pmid:21368390
Schmelzer C et al. The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. 2011 J Med Food pmid:21370964
Lee YJ et al. Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study. 2011 J Med Food pmid:21370966
Esposito M and Carotenuto M Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study. 2011 Neurol. Sci. pmid:20872034
Ochoa JJ et al. Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀. 2011 Free Radic. Biol. Med. pmid:21335087
Farboud ES et al. Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. 2011 Int J Nanomedicine pmid:21674018
Mortensen SA Low coenzyme Q₁₀ levels and the outcome of statin treatment in heart failure. 2011 J. Am. Coll. Cardiol. pmid:21453843
Toyama K et al. Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. 2011 Atherosclerosis pmid:21458815
Taylor MA and Fraser PD Solanesol: added value from Solanaceous waste. 2011 Phytochemistry pmid:21459392