Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

Related references are published most in these journals:

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Young AJ et al. Coenzyme Q10: a review of its promise as a neuroprotectant. 2007 CNS Spectr pmid:17192765
Salles JE et al. Beta-cell function in individuals carrying the mitochondrial tRNA leu (UUR) mutation. 2007 Pancreas pmid:17198195
A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. 2007 Neurology pmid:17200487
Li W et al. [Biological function of CoQ10 and its effect on the quality of spermatozoa]. 2006 Zhonghua Nan Ke Xue pmid:17201263
Khan M et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. 2007 Otolaryngol Head Neck Surg pmid:17210337
Coenzyme Q10. Is it worth the expense? 2006 Mayo Clin Health Lett pmid:17219634
Nutrition and herbs. Cholesterol drug side effects may be linked to low nutrient levels. 2004 Jun-Jul TreatmentUpdate pmid:17219673
Complications and side effects. Health Canada warns about statin side effects. 2005 Jun-Jul TreatmentUpdate pmid:17228470
Le Ber I et al. Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1. 2007 Neurology pmid:17242337
Williams L and Bradford J Should I take coenzyme Q10 with a statin? 2006 JAAPA pmid:17243263
Sakano K et al. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. 2006 Oct-Dec Asian Pac. J. Cancer Prev. pmid:17250435
Hyun DH et al. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. 2007 J. Neurochem. pmid:17250676
Niklowitz P et al. Coenzyme Q10 concentration in plasma and blood cells: what about diurnal changes? 2006 Biofactors pmid:17264392
Vladutiu G Statin-induced adverse effects and malignant hyperthermia susceptibility: comment on the article by Guis et al. 2007 Arthritis Rheum. pmid:17266123
Premkumar VG et al. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. 2007 Biol. Pharm. Bull. pmid:17268082
Lenaz G et al. Mitochondrial Complex I: structure, function, and implications in neurodegeneration. 2006 Sep-Dec Ital. J. Biochem. pmid:17274529
Rosenfeldt FL et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. 2007 J Hum Hypertens pmid:17287847
Xia S et al. Effect of coenzyme Q(10) incorporation on the characteristics of nanoliposomes. 2007 J Phys Chem B pmid:17288474
Wu KL et al. Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor-dependent and caspase-dependent signaling pathways to induce apoptosis after spinal cord injury. 2007 J. Neurochem. pmid:17298387
How well do supplements work? Check this source. 2006 Heart Advis pmid:17299873
Since my heart attack two years ago I have been taking a stain and my cholesterol numbers are excellent. My chiropractor suggests I also should be taking CoQ10 for even better cholesterol health. Does that make sense? 2007 Duke Med Health News pmid:17299892
van der Merwe J et al. Antioxidant therapy for severe cardiac failure induced by iron overload secondary to dyserythropoietic anaemia. 2007 Heart Lung Circ pmid:17314073
Linnane AW et al. The essential requirement for superoxide radical and nitric oxide formation for normal physiological function and healthy aging. 2007 Feb-Apr Mitochondrion pmid:17317335
Folkers K et al. Therapy with coenzyme Q10 of patients in heart failure who are eligible or ineligible for a transplant. 1992 Biochem. Biophys. Res. Commun. pmid:1731784
DiMauro S et al. Mutations in coenzyme Q10 biosynthetic genes. 2007 J. Clin. Invest. pmid:17332886
Mollet J et al. Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. 2007 J. Clin. Invest. pmid:17332895
Shah SA et al. Electrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trial. 2007 Ann Pharmacother pmid:17341532
Teeranachaideekul V et al. Cetyl palmitate-based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies. 2007 Eur J Pharm Biopharm pmid:17346953
Bolcal C et al. Protective effects of antioxidant medications on limb ischemia reperfusion injury. 2007 J. Surg. Res. pmid:17349658
Hershey AD et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. 2007 Headache pmid:17355497
Zhu J et al. Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17360398
Geng A et al. Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages on growth performance and some immune response in ascites-susceptible broilers. 2007 Arch Anim Nutr pmid:17361948
Kaufmann P et al. Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial. 2007 Amyotroph Lateral Scler pmid:17364435
Bailey DM et al. Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle. 2007 Free Radic. Res. pmid:17364944
Sutken E et al. Protective role of melatonin and coenzyme Q10 in ochratoxin A toxicity in rat liver and kidney. 2007 Jan-Feb Int. J. Toxicol. pmid:17365150
Keith M et al. Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation. 2008 Nutr Metab Cardiovasc Dis pmid:17368873
Ohno K and Ohashi T [Diagnosis and treatment of hereditary neurological disorders during childhood]. 2007 No To Hattatsu pmid:17370634
López-Martín JM et al. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. 2007 Hum. Mol. Genet. pmid:17374725
van Dalen EC et al. Prevention of anthracycline-induced cardiotoxicity in children: the evidence. 2007 Eur. J. Cancer pmid:17383867
Hasan SM et al. Oxidative stress alters physiological and morphological neuronal properties. 2007 Neurochem. Res. pmid:17390220
Hargreaves IP et al. Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies. 2007 Mitochondrion pmid:17395552
Gempel K et al. The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene. 2007 Brain pmid:17412732
Yuvaraj S et al. Ameliorating effect of coenzyme Q10, riboflavin and niacin in tamoxifen-treated postmenopausal breast cancer patients with special reference to lipids and lipoproteins. 2007 Clin. Biochem. pmid:17425952
Tsuneki H et al. Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells. 2007 Eur. J. Pharmacol. pmid:17434478
Rötig A et al. Infantile and pediatric quinone deficiency diseases. 2007 Mitochondrion pmid:17442627
Hargreaves IP Coenzyme Q10 in phenylketonuria and mevalonic aciduria. 2007 Mitochondrion pmid:17442628
Miles MV The uptake and distribution of coenzyme Q10. 2007 Mitochondrion pmid:17446143
LeWitt PA Neuroprotection for Parkinson's disease. 2006 J. Neural Transm. Suppl. pmid:17447422
Kalenikova EI et al. Chronic administration of coenzyme Q10 limits postinfarct myocardial remodeling in rats. 2007 Biochemistry Mosc. pmid:17447888
Sheh YL et al. NADPH oxidase- and mitochondrion-derived superoxide at rostral ventrolateral medulla in endotoxin-induced cardiovascular depression. 2007 Free Radic. Biol. Med. pmid:17448908
Ankola DD et al. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? 2007 Eur J Pharm Biopharm pmid:17452099
Martin SF et al. Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model. 2007 Free Radic. Biol. Med. pmid:17462540
Chu CS et al. Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia. 2006 Biofactors pmid:17473378
Cosmeceuticals. A reality check on anti-wrinkle products. 2007 Mayo Clin Womens Healthsource pmid:17476178
Niklowitz P et al. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. 2007 Int. J. Biol. Sci. pmid:17479158
Ha SJ et al. Controlling the sucrose concentration increases Coenzyme Q10 production in fed-batch culture of Agrobacterium tumefaciens. 2007 Appl. Microbiol. Biotechnol. pmid:17479258
Littarru GP and Langsjoen P Coenzyme Q10 and statins: biochemical and clinical implications. 2007 Mitochondrion pmid:17482884
Bhagavan HN and Chopra RK Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. 2007 Mitochondrion pmid:17482886
Linnane AW et al. Coenzyme Q(10)--its role as a prooxidant in the formation of superoxide anion/hydrogen peroxide and the regulation of the metabolome. 2007 Mitochondrion pmid:17482887
Pepe S et al. Coenzyme Q10 in cardiovascular disease. 2007 Mitochondrion pmid:17485243
Cooper JM and Schapira AH Friedreich's ataxia: coenzyme Q10 and vitamin E therapy. 2007 Mitochondrion pmid:17485244
Haas RH The evidence basis for coenzyme Q therapy in oxidative phosphorylation disease. 2007 Mitochondrion pmid:17485245
Barshop BA and Gangoiti JA Analysis of coenzyme Q in human blood and tissues. 2007 Mitochondrion pmid:17485249
Carrozzo R et al. Infantile mitochondrial disorders. 2007 Biosci. Rep. pmid:17486440
Caso G et al. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. 2007 Am. J. Cardiol. pmid:17493470
Witort EJ et al. Autologous lipofilling: coenzyme Q10 can rescue adipocytes from stress-induced apoptotic death. 2007 Plast. Reconstr. Surg. pmid:17496590
Storch A et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. 2007 Arch. Neurol. pmid:17502459
Rusciani L et al. Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. 2007 Melanoma Res. pmid:17505263
Montero R et al. Clinical, biochemical and molecular aspects of cerebellar ataxia and Coenzyme Q10 deficiency. 2007 Cerebellum pmid:17510911
Rahman S and Hargreaves IP Allogeneic stem cell transplantation corrects biochemical derangements in MNGIE. 2007 Neurology pmid:17515557
Premkumar VG et al. Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17516992
Morré DJ et al. ECTO-NOX target for the anticancer isoflavene phenoxodiol. 2007 Oncol. Res. pmid:17518268
de Luca C et al. Beneficial effects of pro-/antioxidant-based nutraceuticals in the skin rejuvenation techniques. 2007 Cell. Mol. Biol. (Noisy-le-grand) pmid:17519117
Bhandari KH et al. Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution. 2007 Biol. Pharm. Bull. pmid:17541177
de Lau LM et al. Serum cholesterol, use of lipid-lowering drugs, and risk of Parkinson disease. 2007 Mov. Disord. pmid:17557354
Cadoni G et al. Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients. 2007 Otol. Neurotol. pmid:17558340
Marcoff L and Thompson PD The role of coenzyme Q10 in statin-associated myopathy: a systematic review. 2007 J. Am. Coll. Cardiol. pmid:17560286
Santos-González M et al. Modifications of plasma proteome in long-lived rats fed on a coenzyme Q10-supplemented diet. 2007 Exp. Gerontol. pmid:17587521
Bolcal C et al. Do N-acetylcystein, beta-glucan, and coenzyme Q10 mollify myocardial ischemia-reperfusion injury? 2007 Heart Surg Forum pmid:17599896
Hellsten Y et al. Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. 2007 Free Radic. Biol. Med. pmid:17602951
Coenzyme Q10. Monograph. 2007 Altern Med Rev pmid:17604461
Singh U et al. Coenzyme Q10 supplementation and heart failure. 2007 Nutr. Rev. pmid:17605305
Houston MC Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals. 2007 Expert Rev Cardiovasc Ther pmid:17605647
Wada H et al. Redox status of coenzyme Q10 is associated with chronological age. 2007 J Am Geriatr Soc pmid:17608895
Tavintharan S et al. Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? 2007 Toxicol. Appl. Pharmacol. pmid:17610923
Nukui K et al. Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake. 2007 J. Nutr. Sci. Vitaminol. pmid:17616008
Hadj A et al. The clinical application of metabolic therapy for cardiovascular disease. 2007 Heart Lung Circ pmid:17618830
Nakanishi M et al. Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. 2007 Circulation pmid:17620516
Ross SM Coenzyme q10: ubiquinone: a potent antioxidant and key energy facilitator for the heart. 2007 Jul-Aug Holist Nurs Pract pmid:17627201
Gudkov LL et al. [Antioxidant and prooxidant action of nitric oxide donors and metabolites]. 2007 May-Jun Biofizika pmid:17633540
Tiano L et al. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. 2007 Eur. Heart J. pmid:17644511
Verma DD et al. Protective effect of coenzyme Q10-loaded liposomes on the myocardium in rabbits with an acute experimental myocardial infarction. 2007 Pharm. Res. pmid:17657597
Ochiai A et al. Improvement in intestinal coenzyme q10 absorption by food intake. 2007 Yakugaku Zasshi pmid:17666877
Yuvaraj S et al. Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin. 2008 Cancer Chemother. Pharmacol. pmid:17668211
Niklowitz P et al. Coenzyme Q10 concentration in the plasma of children suffering from acute lymphoblastic leukaemia before and during induction treatment. 2007 Biofactors pmid:17673825
Mikashinovich ZI et al. [Effect of biologically active food supplement coenzyme Q10 on metabolic processes in the myocardium of rats kept in different temperature conditions]. 2007 Vopr Pitan pmid:17674515
Nucci C et al. Retinal damage caused by high intraocular pressure-induced transient ischemia is prevented by coenzyme Q10 in rat. 2007 Int. Rev. Neurobiol. pmid:17678974
Mabuchi H et al. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. 2007 Atherosclerosis pmid:17681347
Lu J and Frank EL Measurement of coenzyme Q10 in clinical practice. 2007 Clin. Chim. Acta pmid:17689513
Nehilla BJ et al. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. 2008 Int J Pharm pmid:17692482