Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Gökbel H et al. Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in men. 2010 J Med Food pmid:20136458
Roland L et al. Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia. 2010 Hypertens Pregnancy pmid:20132021
Yang X et al. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. 2010 J. Mol. Neurosci. pmid:19834824
Boyer FC et al. Post-polio syndrome: Pathophysiological hypotheses, diagnosis criteria, drug therapy. 2010 Ann Phys Rehabil Med pmid:20093102
Takahashi S et al. Development of coenzyme Q10-enriched rice using sugary and shrunken mutants. 2010 Biosci. Biotechnol. Biochem. pmid:20057142
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Cordero MD et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. 2010 Arthritis Res. Ther. pmid:20109177
Boles RG et al. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. 2010 BMC Neurol pmid:20109231
Glover EI et al. A randomized trial of coenzyme Q10 in mitochondrial disorders. 2010 Muscle Nerve pmid:20886510
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Yenilmez A et al. Antioxidant effects of melatonin and coenzyme Q10 on oxidative damage caused by single-dose ochratoxin A in rat kidney. 2010 Chin J Physiol pmid:21793342
Machado PA et al. Recovery of solanesol from tobacco as a value-added byproduct for alternative applications. 2010 Bioresour. Technol. pmid:19773155
Cheng B et al. Enhanced production of coenzyme Q10 by overexpressing HMG-CoA reductase and induction with arachidonic acid in Schizosaccharomyces pombe. 2010 Appl. Biochem. Biotechnol. pmid:19034698
Evans M et al. A randomized, double-blind, crossover study on the pharmacokinetics of a novel formulation of CoQ₁₀ with pyridoxal 5'-phosphate and phosphatidyl choline. 2010 J Diet Suppl pmid:22432561
Erol B et al. Coenzyme Q10 treatment reduces lipid peroxidation, inducible and endothelial nitric oxide synthases, and germ cell-specific apoptosis in a rat model of testicular ischemia/reperfusion injury. 2010 Fertil. Steril. pmid:19683231
Gökbel H et al. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. 2010 J Strength Cond Res pmid:19644406
Dimitrova S et al. Synthesis of coenzyme Q10 and beta-carotene by yeasts isolated from antarctic soil and lichen in response to ultraviolet and visible radiations. 2010 Appl. Biochem. Biotechnol. pmid:19924388
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Fato R et al. Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy. 2010 Acta Ophthalmol pmid:19799594
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Martin E et al. Hydrogen bonds between nitrogen donors and the semiquinone in the Q(B) site of bacterial reaction centers. 2010 J. Am. Chem. Soc. pmid:20672818
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Cordero MD et al. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. 2010 Clin. Biochem. pmid:20599870
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Pineda M et al. Coenzyme Q(10)-responsive ataxia: 2-year-treatment follow-up. 2010 Mov. Disord. pmid:20629161
Purchas RW et al. Quality characteristics and composition of the longissimus muscle in the short-loin from male and female farmed red deer in New Zealand. 2010 Meat Sci. pmid:20584574
Stear SJ et al. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 10. 2010 Br J Sports Med pmid:20587641
Yuting Tian Y et al. Effects of cell lysis treatments on the yield of coenzyme Q10 following Agrobacterium tumefaciens fermentation. 2010 Food Sci Technol Int pmid:21339135
Beketova NA et al. [Effect of coenzyme Q10 and taurine on the availability of vitamins in the rat experiment]. 2010 Vopr Pitan pmid:21341479
Beketova NA et al. [Effect of dietary fats and supplementary coenzyme Q10 on vitamin provision in animals]. 2010 Vopr Pitan pmid:21395102
Muta-Takada K et al. Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. 2009 Sep-Oct Biofactors pmid:19753652
Buchsbaum R et al. Web-based data management for a phase II clinical trial in ALS. 2009 Oct-Dec Amyotroph Lateral Scler pmid:19922127
Hertz N and Lister RE Improved survival in patients with end-stage cancer treated with coenzyme Q(10) and other antioxidants: a pilot study. 2009 Nov-Dec J. Int. Med. Res. pmid:20146896
Sinatra ST Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. 2009 May-Jun Altern Ther Health Med pmid:19472864
Liu ZX and Artmann C Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. 2009 Mar-Apr Altern Ther Health Med pmid:19284181
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Cusimano EM et al. Mitochondria: the hemi of the cell. 2009 Jan-Mar Adv Emerg Nurs J pmid:20118854
Verhoeven MO et al. The influence of physiological and surgical menopause on coronary heart disease risk markers. 2009 Jan-Feb Menopause pmid:18791484
Plecitá-Hlavatá L et al. Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. 2009 Aug-Sep Int. J. Biochem. Cell Biol. pmid:19433311
Mikoluc B et al. Plasma levels of vitamins A and E, coenzyme Q10, and anti-ox-LDL antibody titer in children treated with an elimination diet due to food hypersensitivity. 2009 Int J Vitam Nutr Res pmid:20533219
D'Andrea G et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. 2009 Neurol. Sci. pmid:19415441
Esteves AR et al. Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. 2009 Antioxid. Redox Signal. pmid:18717628
Haas D et al. Coenzyme Q(10) is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria. 2009 J. Inherit. Metab. Dis. pmid:19504350
Huang ZR et al. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. 2009 Molecules pmid:19169201
Shin JY et al. Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle. 2009 Biochem. Biophys. Res. Commun. pmid:19646960
Skouroliakou M et al. Evaluation of the antioxidant effect of a new functional food enriched with Sideritis euboea in healthy subjects. 2009 J Med Food pmid:19857076
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Lee BL and Ong CN Comprehensive high-performance liquid chromatographic method for the measurements of lipophilic antioxidants in human plasma. 2009 J Chromatogr A pmid:19232623
Lucangioli S et al. A capillary electrophoretic system based on a novel microemulsion for the analysis of coenzyme Q10 in human plasma by electrokinetic chromatography. 2009 Electrophoresis pmid:19517432
Juan YS et al. Coenzyme Q10 diminishes ischemia-reperfusion induced apoptosis and nerve injury in rabbit urinary bladder. 2009 Neurourol. Urodyn. pmid:18837431
Bullon P et al. Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits. 2009 Food Chem. Toxicol. pmid:19545596
Huntsman RJ et al. Hypotonia and infantile spasms: a new phenotype of coenzyme Q10 deficiency? 2009 Can J Neurol Sci pmid:19294900
Jung SY et al. Formulation and evaluation of ubidecarenone transdermal delivery systems. 2009 Drug Dev Ind Pharm pmid:19365779
Kang EY et al. Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers. 2009 Int J Clin Pharmacol Ther pmid:19281730
Kharaeva Z et al. Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients. 2009 Nutrition pmid:19041224
Paliakov EM et al. Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19041283
Asencio C et al. Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans. 2009 Mech. Ageing Dev. pmid:19007804
Fetoni AR et al. Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). 2009 Brain Res. pmid:19133240
Cordero MD et al. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. 2009 Clin. Biochem. pmid:19133251
Cui TZ and Kawamukai M Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe. 2009 FEBS J. pmid:19120452
Siddiqi SA and Thompson PD How do you treat patients with myalgia who take statins? 2009 Curr Atheroscler Rep pmid:19080722
Duncan AJ et al. Decreased ubiquinone availability and impaired mitochondrial cytochrome oxidase activity associated with statin treatment. 2009 Toxicol. Mech. Methods pmid:19778232
Yen HW and Shih TY Coenzyme Q10 production by Rhodobacter sphaeroides in stirred tank and in airlift bioreactor. 2009 Bioprocess Biosyst Eng pmid:19153771
Teran E et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. 2009 Int J Gynaecol Obstet pmid:19154996
Balakrishnan P et al. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. 2009 Int J Pharm pmid:19446761
Safarinejad MR Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. 2009 J. Urol. pmid:19447425
Golomb BA et al. Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study. 2009 Drug Saf pmid:19591530
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Junyaprasert VB et al. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. 2009 Int J Pharm pmid:19465098
Balercia G et al. Coenzyme Q10 and male infertility. 2009 J. Endocrinol. Invest. pmid:19509475
González R et al. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. 2009 Chem. Biol. Interact. pmid:19523936
González-Rubio S et al. Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes. 2009 Chem. Res. Toxicol. pmid:20020783
Yang L et al. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. 2009 J. Neurochem. pmid:19476553
Cano A et al. Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q? 2009 J. Appl. Physiol. pmid:19608932
Zhang J and Wang S Topical use of coenzyme Q10-loaded liposomes coated with trimethyl chitosan: tolerance, precorneal retention and anti-cataract effect. 2009 Int J Pharm pmid:19437594
Okello E et al. Combined statin/coenzyme Q10 as adjunctive treatment of chronic heart failure. 2009 Med. Hypotheses pmid:19409711
Ha SJ et al. Ca2+ increases the specific coenzyme Q10 content in Agrobacterium tumefaciens. 2009 Bioprocess Biosyst Eng pmid:19381690
Kyprianou N et al. Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia. 2009 J. Inherit. Metab. Dis. pmid:19277893
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Seo DW et al. Self-microemulsifying formulation-based oral solution of coenzyme Q10. 2009 Yakugaku Zasshi pmid:19952537
Jung HJ et al. Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals. 2009 J. Pharm. Pharmacol. pmid:19814873
Ho MJ et al. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. 2009 Cochrane Database Syst Rev pmid:19821418
Yuvaraj S et al. Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. 2009 Breast Cancer Res. Treat. pmid:18427979
Lee DS et al. Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration. 2009 J. Physiol. (Lond.) pmid:19805747
Hamilton SJ et al. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. 2009 Diabetes Care pmid:19228872