Coenzyme Q10

Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q10?

Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coenzyme Q10

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
MELAS Syndrome D017241 3 associated lipids
Neglected Diseases D058069 3 associated lipids
Rare Diseases D035583 2 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q10

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coenzyme Q10?

Related references are published most in these journals:

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What functions are associated with Coenzyme Q10?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coenzyme Q10?

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What genes are associated with Coenzyme Q10?

Related references are published most in these journals:


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What common seen animal models are associated with Coenzyme Q10?

Mouse Model

Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coenzyme Q10

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Authors Title Published Journal PubMed Link
Saito Y et al. Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells. 2009 J. Nutr. Biochem. pmid:18602819
Mikoluc B et al. Plasma levels of vitamins A and E, coenzyme Q10, and anti-ox-LDL antibody titer in children treated with an elimination diet due to food hypersensitivity. 2009 Int J Vitam Nutr Res pmid:20533219
D'Andrea G et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. 2009 Neurol. Sci. pmid:19415441
Haas D et al. Coenzyme Q(10) is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria. 2009 J. Inherit. Metab. Dis. pmid:19504350
Shin JY et al. Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle. 2009 Biochem. Biophys. Res. Commun. pmid:19646960
Skouroliakou M et al. Evaluation of the antioxidant effect of a new functional food enriched with Sideritis euboea in healthy subjects. 2009 J Med Food pmid:19857076
Orsucci D et al. Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction. 2009 Nutr. Rev. pmid:19674340
Lee BL and Ong CN Comprehensive high-performance liquid chromatographic method for the measurements of lipophilic antioxidants in human plasma. 2009 J Chromatogr A pmid:19232623
Florkowski C et al. N-3 polyunsaturated fatty acids and statins in heart failure. 2009 Lancet pmid:19186267
Brubaker JW et al. Cystoid macular edema in a patient with chronic progressive external ophthalmoplegia with mitochondrial myopathy. 2009 Ophthalmic Genet. pmid:19172512
Lucangioli S et al. A capillary electrophoretic system based on a novel microemulsion for the analysis of coenzyme Q10 in human plasma by electrokinetic chromatography. 2009 Electrophoresis pmid:19517432
Bullon P et al. Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits. 2009 Food Chem. Toxicol. pmid:19545596
Huntsman RJ et al. Hypotonia and infantile spasms: a new phenotype of coenzyme Q10 deficiency? 2009 Can J Neurol Sci pmid:19294900
Jung SY et al. Formulation and evaluation of ubidecarenone transdermal delivery systems. 2009 Drug Dev Ind Pharm pmid:19365779
Kang EY et al. Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers. 2009 Int J Clin Pharmacol Ther pmid:19281730
Chandran K et al. Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. 2009 Biophys. J. pmid:19217856
Zhong W et al. Enhanced production of CoQ10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation-extraction process. 2009 J. Ind. Microbiol. Biotechnol. pmid:19221819
Abdul-Rasheed OF and Farid YY Development of a new high performance liquid chromatography method for measurement of coenzyme Q10 in healthy blood plasma. 2009 Saudi Med J pmid:19750257
Siddiqi SA and Thompson PD How do you treat patients with myalgia who take statins? 2009 Curr Atheroscler Rep pmid:19080722
Yen HW and Shih TY Coenzyme Q10 production by Rhodobacter sphaeroides in stirred tank and in airlift bioreactor. 2009 Bioprocess Biosyst Eng pmid:19153771
Teran E et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. 2009 Int J Gynaecol Obstet pmid:19154996
Montero R et al. Coenzyme Q10 deficiency associated with a mitochondrial DNA depletion syndrome: a case report. 2009 Clin. Biochem. pmid:19094978
Golomb BA et al. Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study. 2009 Drug Saf pmid:19591530
Novoselova EG et al. Naturally occurring antioxidant nutrients reduce inflammatory response in mice. 2009 Eur. J. Pharmacol. pmid:19463810
Junyaprasert VB et al. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. 2009 Int J Pharm pmid:19465098
Balercia G et al. Coenzyme Q10 and male infertility. 2009 J. Endocrinol. Invest. pmid:19509475
González R et al. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. 2009 Chem. Biol. Interact. pmid:19523936
Yang L et al. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. 2009 J. Neurochem. pmid:19476553
Potgieter M et al. Qualitative electron microscopic analysis of cultured chick embryonic cardiac and skeletal muscle cells: the cellular effect of coenzyme q10 after exposure to triton x-100. 2009 Ultrastruct Pathol pmid:19479649
Graham D et al. Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. 2009 Hypertension pmid:19581509
Choi BS et al. Effect of coenzyme Q10 on cutaneous healing in skin-incised mice. 2009 Arch. Pharm. Res. pmid:19557369
El-ghoroury EA et al. Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control. 2009 Blood Coagul. Fibrinolysis pmid:19530339
Artuch R et al. Coenzyme Q10 deficiencies in neuromuscular diseases. 2009 Adv. Exp. Med. Biol. pmid:20225022
Li CW et al. [CIinical study on treatment of Leber hereditary optic neuropathy]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20214326
Jacobson BH et al. Assessment of the effectiveness of a sublingual, ergogenic spray on muscle strength and power. 2009 J Strength Cond Res pmid:19826292
Isobe C et al. Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients. 2009 Dement Geriatr Cogn Disord pmid:19907182
Ratnam DV et al. The co-encapsulated antioxidant nanoparticles of ellagic acid and coenzyme Q10 ameliorates hyperlipidemia in high fat diet fed rats. 2009 J Nanosci Nanotechnol pmid:19908593
Jung HJ et al. Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals. 2009 J. Pharm. Pharmacol. pmid:19814873
Ho MJ et al. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. 2009 Cochrane Database Syst Rev pmid:19821418
Lee DS et al. Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration. 2009 J. Physiol. (Lond.) pmid:19805747
Mancini A et al. Effects of testosterone on antioxidant systems in male secondary hypogonadism. 2008 Nov-Dec J. Androl. pmid:18641414
Jiang SY and Yu LJ Increasing CoQ10 production by Rhodopseudomonas palustris J001 using a two-stage fermentation process. 2008 Nov-Dec Z. Naturforsch., C, J. Biosci. pmid:19227839
Harinstein ME et al. Normalization of ejection fraction and resolution of symptoms in chronic severe heart failure is possible with modern medical therapy: clinical observations in 11 patients. 2008 May-Jun Am J Ther pmid:18496257
Kitano M et al. Subchronic oral toxicity of ubiquinol in rats and dogs. 2008 Mar-Apr Int. J. Toxicol. pmid:18404543
Rozhnova NA and Gerashchenkov GA [Effect of ubiquinone 50 and viral infection on phytohemagglutinin activity in development of induced resistance in tobacco plants]. 2008 Jul-Aug Izv. Akad. Nauk. Ser. Biol. pmid:18771027
Lunetta S and Roman M Determination of coenzyme Q10 content in raw materials and dietary supplements by high-performance liquid chromatography-UV: collaborative study. 2008 Jul-Aug J AOAC Int pmid:18727527
Premkumar VG et al. Anti-angiogenic potential of CoenzymeQ10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. 2008 Apr-Jun Vascul. Pharmacol. pmid:18407793
Bélanger MC et al. Seasonal mercury exposure and oxidant-antioxidant status of James Bay sport fishermen. 2008 Metab. Clin. Exp. pmid:18442625
Nishimura K et al. Pseudorotaxane-like supramolecular complex of coenzyme Q10 with gamma-cyclodextrin formed by solubility method. 2008 Chem. Pharm. Bull. pmid:18451562
Montini G et al. Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency. 2008 N. Engl. J. Med. pmid:18579827
Stamelou M et al. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. 2008 Mov. Disord. pmid:18464278
Shiomi M et al. Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions. 2008 Br. J. Pharmacol. pmid:18587443
Lekli I et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. 2008 J. Agric. Food Chem. pmid:18543930
Kunitomo M et al. Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. 2008 J. Pharmacol. Sci. pmid:18544898
Nasuti C et al. Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats. 2008 Toxicology pmid:18692543
I need to take statins to lower my cholesterol, but the drug I tried gave me terrible leg cramps. Is there anything I can take to avoid these cramps, or do I have to find another way to lower my cholesterol? 2008 Heart Advis pmid:18693356
Rodríguez-Acuña R et al. Determination of coenzyme Q10 and Q9 in vegetable oils. 2008 J. Agric. Food Chem. pmid:18616270
Chew GT et al. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. 2008 Diabetes Care pmid:18487480
Zmitek J et al. Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. 2008 Ann. Nutr. Metab. pmid:18645245
Wang H et al. [Effects of coenzyme Q10 or combined with micronutrients on antioxidant defense system in rats]. 2008 Wei Sheng Yan Jiu pmid:18646530
Smuda C et al. Self-diffusion in molecular liquids: medium-chain n-alkanes and coenzyme Q10 studied by quasielastic neutron scattering. 2008 J Chem Phys pmid:18624489
Proceedings of the 5th Conference of the International CoQ10 Association, November 9-12, 2007, Kobe, Japan. 2008 Biofactors pmid:19177604
Guo L and Cordeiro MF Assessment of neuroprotection in the retina with DARC. 2008 Prog. Brain Res. pmid:18929126
Russo R et al. Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection. 2008 Prog. Brain Res. pmid:18929135
Mancini A et al. Evaluation of antioxidant systems (coenzyme Q10 and total antioxidant capacity) in morbid obesity before and after biliopancreatic diversion. 2008 Metab. Clin. Exp. pmid:18803943
Makhija N et al. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. 2008 J. Cardiothorac. Vasc. Anesth. pmid:18834786
Hargreaves IP et al. The coenzyme Q10 status of the brain regions of Parkinson's disease patients. 2008 Neurosci. Lett. pmid:18840506
Nakajima Y et al. Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. 2008 Brain Res. pmid:18598676
Kawashiri MA et al. Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study. 2008 Clin. Pharmacol. Ther. pmid:17957184
Cleren C et al. Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism. 2008 J. Neurochem. pmid:17973981
Hirose Y et al. Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs. 2008 Acta Otolaryngol. pmid:18607964
Flattery M Herbal therapies and cardiac side effects. 2008 Prog Cardiovasc Nurs pmid:19067984
Molyneux SL et al. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. 2008 J. Am. Coll. Cardiol. pmid:19017509
Keith M et al. Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation. 2008 Nutr Metab Cardiovasc Dis pmid:17368873
Quinzii CM et al. Human CoQ10 deficiencies. 2008 Biofactors pmid:19096106
Langsjoen PH and Langsjoen AM Supplemental ubiquinol in patients with advanced congestive heart failure. 2008 Biofactors pmid:19096107
Belardinelli R et al. Oxidative stress, endothelial function and coenzyme Q10. 2008 Biofactors pmid:19096108
Adarsh K et al. Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM). 2008 Biofactors pmid:19096110
Sachdanandam P Antiangiogenic and hypolipidemic activity of coenzyme Q10 supplementation to breast cancer patients undergoing Tamoxifen therapy. 2008 Biofactors pmid:19096111
Tiano L et al. Coenzyme Q10 and oxidative imbalance in Down syndrome: biochemical and clinical aspects. 2008 Biofactors pmid:19096112
Li G et al. Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study. 2008 Biofactors pmid:19096113
Schmelzer C et al. Functions of coenzyme Q10 in inflammation and gene expression. 2008 Biofactors pmid:19096114
Teran E et al. Coenzyme Q10 levels in women with preeclampsia living at different altitudes. 2008 Biofactors pmid:19096115
Haas D et al. Plasma and thrombocyte levels of coenzyme Q10 in children with Smith-Lemli-Opitz syndrome (SLOS) and the influence of HMG-CoA reductase inhibitors. 2008 Biofactors pmid:19096116
Hidaka T et al. Safety assessment of coenzyme Q10 (CoQ10). 2008 Biofactors pmid:19096117
Nukui K et al. Blood CoQ10 levels and safety profile after single-dose or chronic administration of PureSorb-Q40: animal and human studies. 2008 Biofactors pmid:19096118
Morré DM et al. Supplementation with CoQ10 lowers age-related (ar) NOX levels in healthy subjects. 2008 Biofactors pmid:19096119
Tjong YW et al. Nitric oxide deficit in chronic intermittent hypoxia impairs large conductance calcium-activated potassium channel activity in rat hippocampal neurons. 2008 Free Radic. Biol. Med. pmid:17996205
Li L et al. Analysis of CoQ10 in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration. 2008 J Pharm Biomed Anal pmid:18054195
Nicolson GL and Conklin KA Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. 2008 Clin. Exp. Metastasis pmid:18058028
Nehilla BJ et al. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. 2008 Int J Pharm pmid:17692482
Florkowski CM et al. Rosuvastatin in older patients with systolic heart failure. 2008 N. Engl. J. Med. pmid:18354111
Li L et al. Urinary excretion study of coenzyme Q10 in rats by ultra-performance liquid chromatography-mass spectrometry. 2008 J Chromatogr Sci pmid:18334087
Miles MV et al. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. 2008 Mitochondrion pmid:18313367
Kon M et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. 2008 Br. J. Nutr. pmid:18284711
Mizuno K et al. Antifatigue effects of coenzyme Q10 during physical fatigue. 2008 Nutrition pmid:18272335
Lagier-Tourenne C et al. ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. 2008 Am. J. Hum. Genet. pmid:18319074
Liu H et al. [Isolation, characterization and fermentation condition of coenzyme Q10 producing strain with solanesol as precursor]. 2008 Wei Sheng Wu Xue Bao pmid:18437995
Ferko M et al. Endogenous protective mechanisms in remodeling of rat heart mitochondrial membranes in the acute phase of streptozotocin-induced diabetes. 2008 Physiol Res pmid:18373390
Matejíková J et al. The effect of antioxidant treatment and NOS inhibition on the incidence of ischemia-induced arrhythmias in the diabetic rat heart. 2008 Physiol Res pmid:18373392