Coenzyme Q6

Coenzyme q6 is a lipid of Prenol Lipids (PR) class. The involved functions are known as methyltransferase activity, Diastasis and Detergents. Coenzyme q6 often locates in Mitochondria. The associated genes with Coenzyme Q6 are SYCP3 gene, P4HTM gene, COQ4 gene, Polypeptides and IFI6 gene.

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Introduction

To understand associated biological information of Coenzyme Q6, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coenzyme Q6?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Coenzyme Q6

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Coenzyme Q6?

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What functions are associated with Coenzyme Q6?


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What lipids are associated with Coenzyme Q6?

There are no associated biomedical information in the current reference collection.

What genes are associated with Coenzyme Q6?

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What common seen animal models are associated with Coenzyme Q6?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Coenzyme Q6

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Authors Title Published Journal PubMed Link
Ismail A et al. Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6. 2016 PLoS Comput. Biol. pmid:26808124
Ozeir M et al. Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae. 2015 J. Biol. Chem. pmid:26260787
He CH et al. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid. 2015 Biochim. Biophys. Acta pmid:26008578
Zhang K et al. A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis. 2014 Genet. Med. pmid:24763291
Doimo M et al. Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. 2014 Biochim. Biophys. Acta pmid:24140869
He CH et al. Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants. 2014 Biochim. Biophys. Acta pmid:24406904
González-Mariscal I et al. Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block. 2014 IUBMB Life pmid:24470391
Ashraf S et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. 2013 J. Clin. Invest. pmid:24270420
Xie LX et al. Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway. 2012 J. Biol. Chem. pmid:22593570
Heeringa SF et al. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. 2011 J. Clin. Invest. pmid:21540551
Martín-Montalvo A et al. Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. 2011 Biochem. J. pmid:21812761
Ozeir M et al. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. 2011 Chem. Biol. pmid:21944752
Zampol MA et al. Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration. 2010 Biochem. Biophys. Res. Commun. pmid:20933507
Zheng L et al. Removal of cadmium(II) from aqueous solution by corn stalk graft copolymers. 2010 Bioresour. Technol. pmid:20335027
Busso C et al. Site-directed mutagenesis and structural modeling of Coq10p indicate the presence of a tunnel for coenzyme Q6 binding. 2010 FEBS Lett. pmid:20303962
Marbois B et al. para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. 2010 J. Biol. Chem. pmid:20592037
Padilla-López S et al. Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. 2009 Biochim. Biophys. Acta pmid:19345667
Padilla S et al. Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. 2009 Cell. Mol. Life Sci. pmid:19002377
Gerencsér L and Maróti P Uncoupling of electron and proton transfers in the photocycle of bacterial reaction centers under high light intensity. 2006 Biochemistry pmid:16634646
Fernández-Ayala DJ et al. Specificity of coenzyme Q10 for a balanced function of respiratory chain and endogenous ubiquinone biosynthesis in human cells. 2005 Biochim. Biophys. Acta pmid:15620378
Barros MH et al. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration. 2005 J. Biol. Chem. pmid:16230336
Marbois B et al. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. 2005 J. Biol. Chem. pmid:15792955
Gao M et al. Indirect identification of isoprenoid quinones in Escherichia coli by LC-MS with atmospheric pressure chemical ionization in negative mode. 2004 J. Basic Microbiol. pmid:15558823
Gin P et al. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. 2003 J. Biol. Chem. pmid:12721307
Echtay KS et al. Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11171965
Mohan S et al. The adult-specific ubiquinone Q(8) functions as an antioxidant in the filarial parasite, Setaria digitata. 2001 Biochem. Biophys. Res. Commun. pmid:11689001
Abhilashkumar R et al. Functional importance of the different ubiquinones in the filarial parasite Setaria digitata. 2001 Biochem. Biophys. Res. Commun. pmid:11350076
Santos-Ocaña C et al. Coenzyme Q6 and iron reduction are responsible for the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiae. 1998 J. Biol. Chem. pmid:9525912
Sippel CJ et al. The regulation of ubiquinone-6 biosynthesis by Saccharomyces cerevisiae. 1983 J. Biol. Chem. pmid:6296069
Goewert RR et al. Identification of 3,4-dihydroxy-5-hexaprenylbenzoic acid as an intermediate in the biosynthesis of ubiquinone-6 by Saccharomyces cerevisiae. 1981 Biochemistry pmid:7025893
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