MeSH term | MeSH ID | Detail |
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Vitamin E Deficiency | D014811 | 29 associated lipids |
Alpha-tocopherol is a lipid of Prenol Lipids (PR) class. Alpha-tocopherol is associated with abnormalities such as Cerebrovascular accident and Cardiovascular Diseases. The involved functions are known as Metabolic Inhibition, Pharmacodynamics, Platelet Adhesiveness and pseudopodium assembly. Alpha-tocopherol often locates in Membrane. The related lipids are Membrane Lipids.
To understand associated biological information of alpha-tocopherol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-tocopherol is suspected in Cerebrovascular accident, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with alpha-tocopherol
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin E Deficiency | D014811 | 29 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Liu Q et al. | Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. | 2017 Mar-Apr | Asian J. Androl. | pmid:26763547 |
Pereira R et al. | Major regulatory mechanisms involved in sperm motility. | 2017 Jan-Feb | Asian J. Androl. | pmid:26680031 |
Fotakis C et al. | NMR Metabolomics Investigates the Influence of Flavonoid-Enriched Rations on Chicken Plasma. | 2017 | J AOAC Int | pmid:28063211 |
Yan H et al. | Hyaluronic acid-modified didecyldimethylammonium bromide/ d-a-tocopheryl polyethylene glycol succinate mixed micelles for delivery of baohuoside I against non-small cell lung cancer: in vitro and in vivo evaluation. | 2017 | Drug Deliv | pmid:28155337 |
Yamamoto Y et al. | The effects of tomato juice on male infertility. | 2017 | Asia Pac J Clin Nutr | pmid:28049263 |
Jin X et al. | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. | 2017 | Int J Nanomedicine | pmid:28761344 |
Hao J et al. | Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles. | 2017 | Int J Nanomedicine | pmid:28392687 |
Mao Y et al. | Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. | 2017 | J. Food Sci. | pmid:28135396 |
Yamanashi Y et al. | Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K. | 2017 | J. Atheroscler. Thromb. | pmid:28100881 |
Bahri S et al. | Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts. | 2017 | PLoS ONE | pmid:28877257 |
Pieszka M et al. | The effect of dietary supplementation with dried fruit and vegetable pomaces on production parameters and meat quality in fattening pigs. | 2017 | Meat Sci. | pmid:27978462 |
Berntsen HF et al. | The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | 2017 | Toxicology | pmid:29037868 |
Ding Y et al. | Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27864002 |
Chakraborty S et al. | Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice. | 2017 | Int J Nanomedicine | pmid:28744120 |
Patel S et al. | Comparative Safety and Efficacy Profile of a Novel Oil in Water Vaccine Adjuvant Comprising Vitamins A and E and a Catechin in Protective Anti-Influenza Immunity. | 2017 | Nutrients | pmid:28531130 |
Gawlik M et al. | Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research. | 2017 | Pharmacol Rep | pmid:28183032 |
Nakazawa T et al. | Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26953980 |
Chen J et al. | Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications. | 2017 | Eur J Pharm Biopharm | pmid:28411056 |
Soussi A et al. | Ameliorated Effects of (-)-Epigallocatechin Gallate Against Toxicity Induced by Vanadium in the Kidneys of Wistar Rats. | 2017 | Biol Trace Elem Res | pmid:28357648 |
Zhang D et al. | Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. | 2017 | Int J Nanomedicine | pmid:28356731 |
Kobori M et al. | Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E. | 2017 | Int J Mol Sci | pmid:28282876 |
Singh SK et al. | Preparation and in-vitro/in-vivo characterization of trans-resveratrol nanocrystals for oral administration. | 2017 | Drug Deliv Transl Res | pmid:28194730 |
Zhang Y et al. | Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo. | 2017 | Int J Nanomedicine | pmid:28144142 |
Yılmaz S et al. | Vitamin E (α tocopherol) attenuates toxicity and oxidative stress induced by aflatoxin in rats. | 2017 | Adv Clin Exp Med | pmid:29068590 |
Leung SS et al. | Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles. | 2017 | AAPS J | pmid:28070713 |
Jang Y et al. | Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. | 2017 | J. Nutr. Biochem. | pmid:28456081 |
Liu HT et al. | Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery. | 2017 | Nutrients | pmid:28054958 |
Wan T et al. | Dual roles of TPGS based microemulsion for tacrolimus: Enhancing the percutaneous delivery and anti-psoriatic efficacy. | 2017 | Int J Pharm | pmid:28629978 |
Queiroz M et al. | New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro: Combined formulations with vitamins C and E. | 2017 | Fitoterapia | pmid:28625733 |
Satué M et al. | Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: in vivo performance and coating stability. | 2017 | Clin Oral Implants Res | pmid:26926140 |
Polanski JF et al. | Antioxidant therapy in the elderly with tinnitus. | 2016 May-Jun | Braz J Otorhinolaryngol | pmid:26547700 |
Parikh P et al. | An open-label randomized control study to compare the efficacy of vitamin e versus ursodeoxycholic acid in nondiabetic and noncirrhotic Indian NAFLD patients. | 2016 May-Jun | Saudi J Gastroenterol | pmid:27184636 |
Beaton MD and Al-Judaibi B | Is vitamin e or ursodeoxycholic acid a valid treatment option for nonalcoholic fatty liver disease in 2016? | 2016 May-Jun | Saudi J Gastroenterol | pmid:27184632 |
Song J et al. | TPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer. | 2016 | Integr Cancer Ther | pmid:26293804 |
Ashraf A et al. | Chemical composition, antioxidant, antitumor, anticancer and cytotoxic effects of Psidium guajava leaf extracts. | 2016 | Pharm Biol | pmid:26841303 |
Li Y et al. | Design and Validation of PEG-Derivatized Vitamin E Copolymer for Drug Delivery into Breast Cancer. | 2016 | Bioconjug. Chem. | pmid:27418000 |
Ebokaiwe AP et al. | Quercetin and vitamin E attenuate Bonny Light crude oil-induced alterations in testicular apoptosis, stress proteins and steroidogenic acute regulatory protein in Wistar rats. | 2016 | Drug Chem Toxicol | pmid:26821606 |
Suksiriworapong J et al. | Comparison of poly(ε-caprolactone) chain lengths of poly(ε-caprolactone)-co-d-α-tocopheryl-poly(ethylene glycol) 1000 succinate nanoparticles for enhancement of quercetin delivery to SKBR3 breast cancer cells. | 2016 | Eur J Pharm Biopharm | pmid:26802701 |
Wu H et al. | Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/d-α-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment. | 2016 | Int J Nanomedicine | pmid:27932881 |
Kumral A et al. | Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats. | 2016 | Hum Exp Toxicol | pmid:26224044 |
Shymanskyy IO et al. | Effects of vitamin D3 and vitamin E on prednisolone-induced alterations of phagocyte function. | 2016 | Eur Rev Med Pharmacol Sci | pmid:27097962 |
Zhu X et al. | The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo. | 2016 | Nanomedicine | pmid:26656634 |
Hu H et al. | A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice. | 2016 | Food Chem. Toxicol. | pmid:27430421 |
Tang Y et al. | Roles of MPBQ-MT in Promoting α/γ-Tocopherol Production and Photosynthesis under High Light in Lettuce. | 2016 | PLoS ONE | pmid:26867015 |
Arrigo R et al. | Biopolyester-based systems containing naturally occurring compounds with enhanced thermo-oxidative stability. | 2016 | J Appl Biomater Funct Mater | pmid:27716869 |
Grimm MO et al. | Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease. | 2016 | Int J Mol Sci | pmid:27801864 |
Eitsuka T et al. | A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27928113 |
Boehm F et al. | A dramatic effect of oxygen on protection of human cells against γ-radiation by lycopene. | 2016 | FEBS Lett. | pmid:26991327 |
Mahipal A et al. | Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites. | 2016 | Cancer Chemother. Pharmacol. | pmid:27278668 |
Zhao L et al. | Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols. | 2016 | Molecules | pmid:26978344 |
Ledet GA et al. | Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection. | 2016 | Int J Mol Sci | pmid:28029115 |
Algayadh IG et al. | Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion. | 2016 | Biol. Pharm. Bull. | pmid:27904039 |
Pathak R et al. | The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). | 2016 | Int J Mol Sci | pmid:27869747 |
Prasad S et al. | γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. | 2016 | Br. J. Cancer | pmid:27575851 |
Dłużewska J et al. | Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. | 2016 | PLoS ONE | pmid:27462710 |
Strenkert D et al. | Genetically Programmed Changes in Photosynthetic Cofactor Metabolism in Copper-deficient Chlamydomonas. | 2016 | J. Biol. Chem. | pmid:27440043 |
Singh VK et al. | Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure. | 2016 | Health Phys | pmid:27356050 |
El-Ela FI et al. | Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | 2016 | Res. Vet. Sci. | pmid:27663366 |
Singh VK and Hauer-Jensen M | γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. | 2016 | Int J Mol Sci | pmid:27153057 |
Kim Y et al. | Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. | 2016 | J. Lipid Res. | pmid:26628639 |
Skrip MM et al. | Dietary antioxidants and flight exercise in female birds affect allocation of nutrients to eggs: how carry-over effects work. | 2016 | J. Exp. Biol. | pmid:27582563 |
Oliveira MS et al. | Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models. | 2016 | Int J Pharm | pmid:27568499 |
Ourique GM et al. | Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats. | 2016 | Food Chem. Toxicol. | pmid:27424124 |
Vijayakumar MR et al. | Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes. | 2016 | Colloids Surf B Biointerfaces | pmid:27236510 |
Wu B et al. | Genistein-loaded nanoparticles of star-shaped diblock copolymer mannitol-core PLGA-TPGS for the treatment of liver cancer. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:26652434 |
Chen G et al. | Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. | 2016 | Int J Mol Sci | pmid:27563875 |
Yan H et al. | Enhanced anticancer activity in vitro and in vivo of luteolin incorporated into long-circulating micelles based on DSPE-PEG2000 and TPGS. | 2016 | J. Pharm. Pharmacol. | pmid:27465923 |
Hou W et al. | pH-Sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo-photodynamic combination therapy. | 2016 | Nanoscale | pmid:26607263 |
Satué M et al. | Improved human gingival fibroblast response to titanium implants coated with ultraviolet-irradiated vitamin D precursor and vitamin E. | 2016 | J. Periodont. Res. | pmid:26271967 |
Patrizi A et al. | Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults. | 2016 | J Dermatolog Treat | pmid:26652026 |
Yang ST et al. | Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion. | 2016 | Nat Commun | pmid:27113279 |
Rosário PW et al. | Radioiodine-induced oxidative stress in patients with differentiated thyroid carcinoma and effect of supplementation with vitamins C and E and selenium (antioxidants). | 2016 | Arch Endocrinol Metab | pmid:26910631 |
Shen Q et al. | Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes. | 2016 | Worldviews Evid Based Nurs | pmid:27243770 |
Kasala ER et al. | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. | 2016 | Pharmacol Rep | pmid:26922533 |
Szuroczki D et al. | Dietary antioxidants enhance immunocompetence in larval amphibians. | 2016 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:27475300 |
Bao Y et al. | A safe, simple and efficient doxorubicin prodrug hybrid micelle for overcoming tumor multidrug resistance and targeting delivery. | 2016 | J Control Release | pmid:27264552 |
Oh H et al. | Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment. | 2016 | Clin Mol Hepatol | pmid:27729634 |
Cheng X et al. | Preparation and in vivo/in vitro evaluation of formononetin phospholipid/vitamin E TPGS micelles. | 2016 | J Drug Target | pmid:26325229 |
Sawangjit R et al. | Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis. | 2016 | Medicine (Baltimore) | pmid:27512874 |
Yung HW et al. | Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants. | 2016 | Diabetologia | pmid:27406815 |
Williams CA | The effect of oxidative stress during exercise in the horse. | 2016 | J. Anim. Sci. | pmid:27898872 |
Patel S et al. | Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses. | 2016 | Immunology | pmid:27135790 |
Lipovac M et al. | Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. | 2016 | Reprod. Biol. Endocrinol. | pmid:27938385 |
Yamashita S et al. | γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27055589 |
Hanson C et al. | Serum tocopherol levels and vitamin E intake are associated with lung function in the normative aging study. | 2016 | Clin Nutr | pmid:25715694 |
Liu HT et al. | Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. | 2016 | Nutr J | pmid:27716246 |
Liu S et al. | Evaluation on oxidative stability of walnut beverage emulsions. | 2016 | Food Chem | pmid:26948632 |
Ha ES et al. | Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process. | 2015 | Drug Des Devel Ther | pmid:26345723 |
Ebokaiwe AP and Farombi EO | Influence of vitamin E and quercetin on Nigerian Bonny Light crude oil-induced neuronal and testicular toxicity in Wistar rats. | 2015 | J Basic Clin Physiol Pharmacol | pmid:25046308 |
Chen YC et al. | Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles. | 2015 | Int J Nanomedicine | pmid:26664117 |
Sugahara R et al. | Annatto Tocotrienol Induces a Cytotoxic Effect on Human Prostate Cancer PC3 Cells via the Simultaneous Inhibition of Src and Stat3. | 2015 | J. Nutr. Sci. Vitaminol. | pmid:26875492 |
Springett GM et al. | A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia. | 2015 | EBioMedicine | pmid:26844278 |
Meganathan P et al. | A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects. | 2015 | Sci Rep | pmid:26323969 |
Kim EH et al. | Fibrillin 5 Is Essential for Plastoquinone-9 Biosynthesis by Binding to Solanesyl Diphosphate Synthases in Arabidopsis. | 2015 | Plant Cell | pmid:26432861 |
Parajuli P et al. | Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis. | 2015 | Biol. Pharm. Bull. | pmid:26328490 |
Gu W et al. | Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. | 2015 | BMC Cancer | pmid:26315028 |
Abdel-Hamid AA and Firgany Ael-D | Vitamin E supplementation ameliorates aflatoxin B1-induced nephrotoxicity in rats. | 2015 | Acta Histochem. | pmid:26315992 |
Ni Y et al. | Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. | 2015 | Sci Rep | pmid:26603489 |
Apostolidou C et al. | Alterations of antioxidant status in asymptomatic hypercholesterolemic individuals after resveratrol intake. | 2015 | Int J Food Sci Nutr | pmid:27108746 |
Demirci H et al. | Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. | 2015 | Turk J Gastroenterol | pmid:26510082 |