| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
alpha-tocotrienol
Alpha-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 443 references associated with alpha-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-tocotrienol
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All references with alpha-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakazawa T et al. | Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26953980 |
| Takano H et al. | γ-Tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2. | 2015 | Int. J. Oncol. | pmid:25625649 |
| Walde CM et al. | Comparison of dietary tocotrienols from barley and palm oils in hen's egg yolk: transfer efficiency, influence of emulsification, and effect on egg cholesterol. | 2014 | J. Sci. Food Agric. | pmid:24254057 |
| Lim SW et al. | Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. | 2014 | BMC Complement Altern Med | pmid:25480449 |
| Zhang GY et al. | Increased α-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis γ-tocopherol methyltransferase. | 2013 | Transgenic Res. | pmid:22763462 |
| Hagl S et al. | Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. | 2013 | Pharmacol. Res. | pmid:23827162 |
| Mangialasche F et al. | Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol. | 2013 | J. Intern. Med. | pmid:23343471 |
| Siles L et al. | Vitamin E analyses in seeds reveal a dominant presence of tocotrienols over tocopherols in the Arecaceae family. | 2013 | Phytochemistry | pmid:23920227 |
| Jung NY et al. | Neuroprotective effects of α-tocotrienol on kainic acid-induced neurotoxicity in organotypic hippocampal slice cultures. | 2013 | Int J Mol Sci | pmid:24013375 |
| Fukui K et al. | Tocotrienol prevents AAPH-induced neurite degeneration in neuro2a cells. | 2013 | Redox Rep. | pmid:24112959 |
| Loganathan R et al. | Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. | 2013 | Cell Prolif. | pmid:23510475 |
| Uchida T et al. | Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol. | 2012 | Lipids | pmid:22042641 |
| Fairus S et al. | Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation. | 2012 | Nutr J | pmid:22252050 |
| Constantinou C et al. | Induction of DNA damage and caspase-independent programmed cell death by vitamin E. | 2012 | Nutr Cancer | pmid:22172208 |
| Fukui K et al. | Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells. | 2012 | Free Radic. Res. | pmid:22149330 |
| Büsing A et al. | Identification of α-tocotrienolquinone epoxides and development of an efficient molecular distillation procedure for quantitation of α-tocotrienol oxidation products in food matrices by high-performance liquid chromatography with diode array and fluorescence detection. | 2012 | J. Agric. Food Chem. | pmid:22747466 |
| Wong RS et al. | δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells. | 2012 | Microsc. Microanal. | pmid:22640960 |
| Krycer JR et al. | A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. | 2012 | Biochem. J. | pmid:22657538 |
| Wilankar C et al. | Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols. | 2011 | Free Radic. Biol. Med. | pmid:21536125 |
| Ha H et al. | α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21352805 |
| Tan SW et al. | Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. | 2011 | Cell. Immunol. | pmid:21839427 |
| Park HA et al. | Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. | 2011 | Stroke | pmid:21719775 |
| Uchida T et al. | Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:22293209 |
| Shrader WD et al. | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21600768 |
| Saito Y et al. | Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. | 2010 | Free Radic. Biol. Med. | pmid:20736061 |
| Behery FA et al. | Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors. | 2010 | Bioorg. Med. Chem. | pmid:20943398 |
| Elnagar AY et al. | Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. | 2010 | Bioorg. Med. Chem. | pmid:20022507 |
| Pierpaoli E et al. | Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. | 2010 | Life Sci. | pmid:20188744 |
| Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
| Gogvadze V et al. | Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. | 2010 | Int. J. Cancer | pmid:20104525 |
| Khanna S et al. | Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. | 2010 | J. Neurochem. | pmid:20028458 |
| Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
| Napolitano M et al. | Effects of new combinative antioxidant FeAOX-6 and alpha-tocotrienol on macrophage atherogenesis-related functions. | 2007 | Vascul. Pharmacol. | pmid:17331802 |
| Yu SG et al. | Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens. | 2006 | Lipids | pmid:16933790 |
| Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
| Chênevert R et al. | Chemoenzymatic synthesis of both enantiomers of alpha-tocotrienol. | 2006 | Bioorg. Med. Chem. | pmid:16616508 |
| Numakawa Y et al. | Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. | 2006 | J. Neurochem. | pmid:16686696 |
| Khanna S et al. | Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. | 2006 | J. Neurochem. | pmid:16923160 |
| Khanna S et al. | Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. | 2005 | Free Radic. Biol. Med. | pmid:16257640 |
| Khanna S et al. | Neuroprotective properties of the natural vitamin E alpha-tocotrienol. | 2005 | Stroke | pmid:16166580 |
| Mooney LA et al. | Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15668500 |
| Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
| Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
| Saito Y et al. | Characterization of cellular uptake and distribution of vitamin E. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753172 |
| Osakada F et al. | Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. | 2004 | Neuropharmacology | pmid:15527824 |
| Norazlina M et al. | Vitamin E deficiency reduced lumbar bone calcium content in female rats. | 2004 | Med. J. Malaysia | pmid:15889565 |
| Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
| Noguchi N et al. | Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. | 2003 | Free Radic. Biol. Med. | pmid:12788481 |
| Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
| Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
| Weber SU et al. | Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. | 2003 | Free Radic. Biol. Med. | pmid:12521598 |
| Mishima K et al. | Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice. | 2003 | Neurosci. Lett. | pmid:12524170 |
| Khanna S et al. | Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. | 2003 | J. Biol. Chem. | pmid:12917400 |
| Theriault A et al. | Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. | 2002 | Atherosclerosis | pmid:11755919 |
| Begum AN and Terao J | Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999415 |
| Yamashita K et al. | Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols. | 2002 | Lipids | pmid:12030315 |
| Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
| Lodge JK et al. | Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. | 2001 | Lipids | pmid:11214728 |
| Kaushik S et al. | Removal of fat from cow's milk decreases the vitamin E contents of the resulting dairy products. | 2001 | Lipids | pmid:11214733 |
| Packer L et al. | Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. | 2001 | J. Nutr. | pmid:11160563 |
| Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
| Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
| Drotleff AM and Ternes W | Determination of RS,E/Z-tocotrienols by HPLC. | 2001 | J Chromatogr A | pmid:11269521 |
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| Kamat JP and Devasagayam TP | Oxidative damage to mitochondria in normal and cancer tissues, and its modulation. | 2000 | Toxicology | pmid:11154799 |
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| Adachi H and Ishii N | Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. | 2000 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:10843344 |
| Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
| Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
| Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
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| Traber MG et al. | Penetration and distribution of alpha-tocopherol, alpha- or gamma-tocotrienols applied individually onto murine skin. | 1998 | Lipids | pmid:9470177 |
| Nesaretnam K et al. | Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. | 1998 | Lipids | pmid:9625593 |
| Surai PF and Speake BK | Selective excretion of yolk-derived tocotrienols into the bile of the chick embryo. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9972310 |
| Guthrie N et al. | Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. | 1997 | J. Nutr. | pmid:9082043 |
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