| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
alpha-tocotrienol
Alpha-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 443 references associated with alpha-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for alpha-tocotrienol
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-tocotrienol
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with alpha-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
| Weimann BJ and Weiser H | Functions of vitamin E in reproduction and in prostacyclin and immunoglobulin synthesis in rats. | 1991 | Am. J. Clin. Nutr. | pmid:2012018 |
| Saito Y et al. | Characterization of cellular uptake and distribution of vitamin E. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753172 |
| Theriault A et al. | Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. | 2002 | Atherosclerosis | pmid:11755919 |
| Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
| Ha H et al. | α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21352805 |
| Krycer JR et al. | A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. | 2012 | Biochem. J. | pmid:22657538 |
| Suzuki YJ et al. | Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. | 1993 | Biochemistry | pmid:8399214 |
| Suarna C et al. | Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. | 1993 | Biochim. Biophys. Acta | pmid:8443232 |
| Behery FA et al. | Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors. | 2010 | Bioorg. Med. Chem. | pmid:20943398 |
| Elnagar AY et al. | Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. | 2010 | Bioorg. Med. Chem. | pmid:20022507 |
| Chênevert R et al. | Chemoenzymatic synthesis of both enantiomers of alpha-tocotrienol. | 2006 | Bioorg. Med. Chem. | pmid:16616508 |
| Shrader WD et al. | α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21600768 |
| Begum AN and Terao J | Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999415 |
| Lim SW et al. | Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. | 2014 | BMC Complement Altern Med | pmid:25480449 |
| Mooney LA et al. | Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15668500 |
| Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
| Loganathan R et al. | Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. | 2013 | Cell Prolif. | pmid:23510475 |
| Tan SW et al. | Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. | 2011 | Cell. Immunol. | pmid:21839427 |
| Surai PF and Speake BK | Selective excretion of yolk-derived tocotrienols into the bile of the chick embryo. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9972310 |
| Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
| Nakamura H et al. | Oral toxicity of a tocotrienol preparation in rats. | 2001 | Food Chem. Toxicol. | pmid:11434987 |
| Noguchi N et al. | Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. | 2003 | Free Radic. Biol. Med. | pmid:12788481 |
| Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
| Weber SU et al. | Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. | 2003 | Free Radic. Biol. Med. | pmid:12521598 |
| Katsanidis E and Addis PB | Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. | 1999 | Free Radic. Biol. Med. | pmid:10641704 |
| Saito Y et al. | Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. | 2010 | Free Radic. Biol. Med. | pmid:20736061 |
| Wilankar C et al. | Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols. | 2011 | Free Radic. Biol. Med. | pmid:21536125 |
| Khanna S et al. | Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. | 2005 | Free Radic. Biol. Med. | pmid:16257640 |
| Serbinova E et al. | Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. | 1991 | Free Radic. Biol. Med. | pmid:1649783 |
| Fukui K et al. | Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells. | 2012 | Free Radic. Res. | pmid:22149330 |
| Jung NY et al. | Neuroprotective effects of α-tocotrienol on kainic acid-induced neurotoxicity in organotypic hippocampal slice cultures. | 2013 | Int J Mol Sci | pmid:24013375 |
| Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
| Heinonen M and Piironen V | The tocopherol, tocotrienol, and vitamin E content of the average Finnish diet. | 1991 | Int J Vitam Nutr Res | pmid:1856041 |
| Järvinen R | Carotenoids, retinoids, tocopherols and tocotrienols in the diet; the Finnish Mobile Clinic Health Examination Survey. | 1995 | Int J Vitam Nutr Res | pmid:7657476 |
| Ong FB et al. | Vitamin E, glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured hepatocytes of rats treated with carcinogens. | 1994 | Int. J. Biochem. | pmid:7910569 |
| Gogvadze V et al. | Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. | 2010 | Int. J. Cancer | pmid:20104525 |