| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
alpha-tocotrienol
Alpha-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 443 references associated with alpha-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for alpha-tocotrienol
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-tocotrienol
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with alpha-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
| Katsanidis E and Addis PB | Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. | 1999 | Free Radic. Biol. Med. | pmid:10641704 |
| McIntyre BS et al. | Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. | 2000 | Lipids | pmid:10757548 |
| Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
| Adachi H and Ishii N | Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. | 2000 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:10843344 |
| Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
| Kamat JP and Devasagayam TP | Oxidative damage to mitochondria in normal and cancer tissues, and its modulation. | 2000 | Toxicology | pmid:11154799 |
| Packer L et al. | Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. | 2001 | J. Nutr. | pmid:11160563 |
| Yap SP et al. | Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. | 2001 | J. Pharm. Pharmacol. | pmid:11206194 |
| Lodge JK et al. | Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. | 2001 | Lipids | pmid:11214728 |
| Kaushik S et al. | Removal of fat from cow's milk decreases the vitamin E contents of the resulting dairy products. | 2001 | Lipids | pmid:11214733 |
| Drotleff AM and Ternes W | Determination of RS,E/Z-tocotrienols by HPLC. | 2001 | J Chromatogr A | pmid:11269521 |
| Nakamura H et al. | Oral toxicity of a tocotrienol preparation in rats. | 2001 | Food Chem. Toxicol. | pmid:11434987 |
| Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
| Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
| Theriault A et al. | Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. | 2002 | Atherosclerosis | pmid:11755919 |
| Begum AN and Terao J | Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999415 |
| Yamashita K et al. | Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols. | 2002 | Lipids | pmid:12030315 |
| Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
| Weber SU et al. | Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. | 2003 | Free Radic. Biol. Med. | pmid:12521598 |
| Mishima K et al. | Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice. | 2003 | Neurosci. Lett. | pmid:12524170 |
| Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
| Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
| Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
| Noguchi N et al. | Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. | 2003 | Free Radic. Biol. Med. | pmid:12788481 |
| Khanna S et al. | Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. | 2003 | J. Biol. Chem. | pmid:12917400 |
| Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
| Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
| Osakada F et al. | Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. | 2004 | Neuropharmacology | pmid:15527824 |
| Mooney LA et al. | Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15668500 |
| Saito Y et al. | Characterization of cellular uptake and distribution of vitamin E. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753172 |
| Norazlina M et al. | Vitamin E deficiency reduced lumbar bone calcium content in female rats. | 2004 | Med. J. Malaysia | pmid:15889565 |
| Khanna S et al. | Neuroprotective properties of the natural vitamin E alpha-tocotrienol. | 2005 | Stroke | pmid:16166580 |
| Khanna S et al. | Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. | 2005 | Free Radic. Biol. Med. | pmid:16257640 |
| Serbinova E et al. | Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. | 1991 | Free Radic. Biol. Med. | pmid:1649783 |
| Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
| Chênevert R et al. | Chemoenzymatic synthesis of both enantiomers of alpha-tocotrienol. | 2006 | Bioorg. Med. Chem. | pmid:16616508 |
| Numakawa Y et al. | Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. | 2006 | J. Neurochem. | pmid:16686696 |
| Khanna S et al. | Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. | 2006 | J. Neurochem. | pmid:16923160 |
| Yu SG et al. | Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens. | 2006 | Lipids | pmid:16933790 |
| Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
| Napolitano M et al. | Effects of new combinative antioxidant FeAOX-6 and alpha-tocotrienol on macrophage atherogenesis-related functions. | 2007 | Vascul. Pharmacol. | pmid:17331802 |
| Heinonen M and Piironen V | The tocopherol, tocotrienol, and vitamin E content of the average Finnish diet. | 1991 | Int J Vitam Nutr Res | pmid:1856041 |
| Elnagar AY et al. | Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. | 2010 | Bioorg. Med. Chem. | pmid:20022507 |
| Khanna S et al. | Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. | 2010 | J. Neurochem. | pmid:20028458 |
| Gogvadze V et al. | Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. | 2010 | Int. J. Cancer | pmid:20104525 |
| Weimann BJ and Weiser H | Functions of vitamin E in reproduction and in prostacyclin and immunoglobulin synthesis in rats. | 1991 | Am. J. Clin. Nutr. | pmid:2012018 |
| Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
| Pierpaoli E et al. | Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. | 2010 | Life Sci. | pmid:20188744 |