alpha-tocotrienol

Alpha-tocotrienol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 443 references associated with alpha-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for alpha-tocotrienol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-tocotrienol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

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Heinonen M and Piironen V The tocopherol, tocotrienol, and vitamin E content of the average Finnish diet. 1991 Int J Vitam Nutr Res pmid:1856041
Serbinova E et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. 1991 Free Radic. Biol. Med. pmid:1649783
Weimann BJ and Weiser H Functions of vitamin E in reproduction and in prostacyclin and immunoglobulin synthesis in rats. 1991 Am. J. Clin. Nutr. pmid:2012018
Suzuki YJ et al. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. 1993 Biochemistry pmid:8399214
Suarna C et al. Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. 1993 Biochim. Biophys. Acta pmid:8443232
Wang L et al. Tocotrienol and fatty acid composition of barley oil and their effects on lipid metabolism. 1993 Plant Foods Hum Nutr pmid:8464850
Ong FB et al. Vitamin E, glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured hepatocytes of rats treated with carcinogens. 1994 Int. J. Biochem. pmid:7910569
Yamaoka M and Komiyama K Antioxidative activity of tocotrienol in heterogeneous system: indication of restriction within membrane by fluorescence measurement. 1994 Meth. Enzymol. pmid:7808301
Serbinova EA and Packer L Antioxidant properties of alpha-tocopherol and alpha-tocotrienol. 1994 Meth. Enzymol. pmid:7808307
Järvinen R Carotenoids, retinoids, tocopherols and tocotrienols in the diet; the Finnish Mobile Clinic Health Examination Survey. 1995 Int J Vitam Nutr Res pmid:7657476
Kamat JP and Devasagayam TP Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. 1995 Neurosci. Lett. pmid:8584204
Adam A et al. Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses. 1996 Pharmacol. Toxicol. pmid:9000262
Konings EJ et al. Liquid chromatographic determination of tocopherols and tocotrienols in margarine, infant foods, and vegetables. 1996 Jul-Aug J AOAC Int pmid:8757449
Guthrie N et al. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. 1997 J. Nutr. pmid:9082043
Kamat JP et al. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. 1997 Mol. Cell. Biochem. pmid:9144327
Traber MG et al. Penetration and distribution of alpha-tocopherol, alpha- or gamma-tocotrienols applied individually onto murine skin. 1998 Lipids pmid:9470177
Nesaretnam K et al. Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. 1998 Lipids pmid:9625593
Surai PF and Speake BK Selective excretion of yolk-derived tocotrienols into the bile of the chick embryo. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9972310
Yu W et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. 1999 Nutr Cancer pmid:10227040
Katsanidis E and Addis PB Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. 1999 Free Radic. Biol. Med. pmid:10641704
Kamat JP and Devasagayam TP Oxidative damage to mitochondria in normal and cancer tissues, and its modulation. 2000 Toxicology pmid:11154799
McIntyre BS et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. 2000 Lipids pmid:10757548
Adachi H and Ishii N Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. 2000 J. Gerontol. A Biol. Sci. Med. Sci. pmid:10843344
Black TM et al. Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. 2000 J. Nutr. pmid:11015467
Sen CK et al. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. 2000 J. Biol. Chem. pmid:10777609
Lodge JK et al. Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. 2001 Lipids pmid:11214728
Kaushik S et al. Removal of fat from cow's milk decreases the vitamin E contents of the resulting dairy products. 2001 Lipids pmid:11214733
Packer L et al. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. 2001 J. Nutr. pmid:11160563
Ikeda S et al. Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. 2001 J. Nutr. pmid:11694614
Sylvester PW et al. Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. 2001 Cell Prolif. pmid:11736999
Drotleff AM and Ternes W Determination of RS,E/Z-tocotrienols by HPLC. 2001 J Chromatogr A pmid:11269521
Nakamura H et al. Oral toxicity of a tocotrienol preparation in rats. 2001 Food Chem. Toxicol. pmid:11434987
Yap SP et al. Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. 2001 J. Pharm. Pharmacol. pmid:11206194
Theriault A et al. Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. 2002 Atherosclerosis pmid:11755919
Begum AN and Terao J Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability. 2002 Biosci. Biotechnol. Biochem. pmid:11999415
Yamashita K et al. Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols. 2002 Lipids pmid:12030315
Mustad VA et al. Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. 2002 Am. J. Clin. Nutr. pmid:12450888