delta-tocotrienol

Delta-tocotrienol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 456 references associated with delta-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for delta-tocotrienol

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We collected disease MeSH terms mapped to the references associated with delta-tocotrienol

MeSH term MeSH ID Detail
Weight Gain D015430 101 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

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All references with delta-tocotrienol

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Authors Title Published Journal PubMed Link
Eitsuka T et al. A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells. 2016 J. Nutr. Sci. Vitaminol. pmid:27928113
Mahipal A et al. Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites. 2016 Cancer Chemother. Pharmacol. pmid:27278668
Zhao L et al. Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols. 2016 Molecules pmid:26978344
Sugahara R et al. Annatto Tocotrienol Induces a Cytotoxic Effect on Human Prostate Cancer PC3 Cells via the Simultaneous Inhibition of Src and Stat3. 2015 J. Nutr. Sci. Vitaminol. pmid:26875492
Springett GM et al. A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia. 2015 EBioMedicine pmid:26844278
Meganathan P et al. A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects. 2015 Sci Rep pmid:26323969
Wang C et al. EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. 2015 J. Nutr. Biochem. pmid:25997867
Ye C et al. δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. 2015 PLoS ONE pmid:25849286
Li XH et al. Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury. 2015 PLoS ONE pmid:25815474
Hsu PY and Yang YW Gene delivery via the hybrid vector of recombinant adeno-associated virus and polyethylenimine. 2014 Eur J Pharm Sci pmid:24184196
Lim SW et al. Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. 2014 BMC Complement Altern Med pmid:25480449
Ananthula S et al. δ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxia. 2014 Biomed Res Int pmid:25140303
Haleagrahara N et al. Therapeutic efficacy of vitamin E δ-tocotrienol in collagen-induced rat model of arthritis. 2014 Biomed Res Int pmid:25114906
Ananthula S et al. Oxazine derivatives of γ- and δ-tocotrienol display enhanced anticancer activity in vivo. 2014 Anticancer Res. pmid:24922632
Singh VK et al. Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. 2014 Life Sci. pmid:24486300
Viola V et al. Mitochondrial-dependent anticancer activity of δ-tocotrienol and its synthetic derivatives in HER-2/neu overexpressing breast adenocarcinoma cells. 2013 Jul-Aug Biofactors pmid:23361894
Rodzian MN et al. Pure tocotrienol concentrate protected rat gastric mucosa from acute stress-induced injury by a non-antioxidant mechanism. 2013 Pol J Pathol pmid:23625601
Behery FA et al. Optimization of tocotrienols as antiproliferative and antimigratory leads. 2013 Eur J Med Chem pmid:23274571
Hodul PJ et al. Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. 2013 PLoS ONE pmid:23393547
Husain K et al. Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol. 2013 Carcinogenesis pmid:23302291
Li XH et al. Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury. 2013 Radiat. Res. pmid:24294967
Husain K et al. Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. 2013 Cancer Prev Res (Phila) pmid:23963802
Loganathan R et al. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. 2013 Cell Prolif. pmid:23510475
Qureshi AA et al. Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects. 2013 J Clin Exp Cardiolog pmid:24319627
Forster GM et al. Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth. 2013 Food Chem pmid:23790950
Constantinou C et al. Induction of DNA damage and caspase-independent programmed cell death by vitamin E. 2012 Nutr Cancer pmid:22172208
Wong RS et al. δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells. 2012 Microsc. Microanal. pmid:22640960
Ji X et al. Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway. 2012 Anticancer Res. pmid:22753722
Satyamitra M et al. Mechanism of radioprotection by δ-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways. 2012 Br J Radiol pmid:22674714
Yue MA et al. [Experimental study on delta-tocotrienol inhibits the Wnt pathway in the colon cancer cell SW620]. 2012 Wei Sheng Yan Jiu pmid:23424864
Ji X et al. Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. 2012 Int. J. Cancer pmid:22438124
Krycer JR et al. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. 2012 Biochem. J. pmid:22657538
Katuru R et al. Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. 2011 Exp. Biol. Med. (Maywood) pmid:21540247
Tan SW et al. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. 2011 Cell. Immunol. pmid:21839427
Satyamitra MM et al. Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-Tocotrienol. 2011 Radiat. Res. pmid:21434782
Zhang JS et al. A paraptosis-like cell death induced by δ-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway. 2011 Toxicology pmid:21453743
Chen J et al. Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts. 2011 Circulation pmid:21282499
Ji X et al. Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. 2011 J. Cell. Biochem. pmid:21598300
Qureshi AA et al. Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin. 2011 Lipids Health Dis pmid:22185406
Husain K et al. Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer. 2011 Mol. Cancer Ther. pmid:21971120
Brooks R et al. Direct inhibition of osteoclast formation and activity by the vitamin E isomer gamma-tocotrienol. 2011 Int J Vitam Nutr Res pmid:22673919
Qureshi AA et al. δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens. 2011 Lipids Health Dis pmid:21356098
Pierpaoli E et al. Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. 2010 Life Sci. pmid:20188744
Zaiden N et al. Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. 2010 J. Atheroscler. Thromb. pmid:20702976
Li XH et al. Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. 2010 Haematologica pmid:20823133
Michihara A et al. Effect of δ-tocotrienol on melanin content and enzymes for melanin synthesis in mouse melanoma cells. 2010 Biol. Pharm. Bull. pmid:20823559
Mudit M et al. Synthesis of fluorescent analogues of the anticancer natural products 4-hydroxyphenylmethylene hydantoin and delta-tocotrienol. 2010 Nat Prod Commun pmid:21121261
Fernandes NV et al. d-δ-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells. 2010 Anticancer Res. pmid:21187473
Yap WN et al. Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. 2010 Pigment Cell Melanoma Res pmid:20609176
Shibata A et al. alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells. 2010 Biochem. Biophys. Res. Commun. pmid:20493172