| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
gamma-tocotrienol
Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for gamma-tocotrienol
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol
PubChem Biomolecular Interactions and Pathways
NCBI Entrez Crosslinks
All references with gamma-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
| Qureshi AA et al. | Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). | 1991 | Am. J. Clin. Nutr. | pmid:2012010 |
| Conte C et al. | Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753178 |
| Raederstorff D et al. | Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters. | 2002 | Ann. Nutr. Metab. | pmid:11914511 |
| Bachawal SV et al. | Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. | 2010 | Anticancer Res. | pmid:20332450 |
| Ananthula S et al. | Oxazine derivatives of γ- and δ-tocotrienol display enhanced anticancer activity in vivo. | 2014 | Anticancer Res. | pmid:24922632 |
| Hsieh TC et al. | gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells. | 2010 | Anticancer Res. | pmid:20683025 |
| Wali VB et al. | Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. | 2009 | Apoptosis | pmid:19771520 |
| Theriault A et al. | Effects of gamma-tocotrienol on ApoB synthesis, degradation, and secretion in HepG2 cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073977 |
| Pintha K et al. | Anti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.). | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969892 |
| Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
| Wang Q et al. | Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618265 |
| Yamashita S et al. | γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27055589 |
| Shah SJ and Sylvester PW | Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. | 2005 | Biochem. Cell Biol. | pmid:15746970 |
| Zbierzak AM et al. | Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. | 2010 | Biochem. J. | pmid:19843012 |
| Krycer JR et al. | A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. | 2012 | Biochem. J. | pmid:22657538 |
| Nowicka B et al. | Function of plastochromanol and other biological prenyllipids in the inhibition of lipid peroxidation-A comparative study in model systems. | 2013 | Biochim. Biophys. Acta | pmid:22959712 |
| Suarna C et al. | Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. | 1993 | Biochim. Biophys. Acta | pmid:8443232 |
| Algayadh IG et al. | Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion. | 2016 | Biol. Pharm. Bull. | pmid:27904039 |
| Parajuli P et al. | Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis. | 2015 | Biol. Pharm. Bull. | pmid:26328490 |
| Hattori A et al. | Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats. | 2000 | Biol. Pharm. Bull. | pmid:11085376 |
| Liang S et al. | Development and validation of a sensitive LC/MS/MS method for the determination of γ-tocotrienol in rat plasma: application to pharmacokinetic studies. | 2013 | Biomed. Chromatogr. | pmid:22522964 |
| Abuasal B et al. | Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. | 2011 | Biomed. Chromatogr. | pmid:20734323 |
| Shirode AB and Sylvester PW | Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. | 2010 | Biomed. Pharmacother. | pmid:19954924 |
| Kawakami Y et al. | Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284857 |
| Zhifang M et al. | The androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells. | 2015 | BMC Biochem. | pmid:25943311 |
| Bachawal SV et al. | Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. | 2010 | BMC Cancer | pmid:20211018 |
| Gu W et al. | Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. | 2015 | BMC Cancer | pmid:26315028 |
| Lim SW et al. | Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. | 2014 | BMC Complement Altern Med | pmid:25480449 |
| Abdul Rahman A et al. | Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells. | 2014 | BMC Complement Altern Med | pmid:24980711 |
| Liu J et al. | Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK. | 2014 | BMC Complement Altern Med | pmid:25129068 |
| Abdul Rahman Sazli F et al. | Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. | 2015 | BMC Complement Altern Med | pmid:25886747 |
| Zainuddin A et al. | Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts. | 2010 | BMC Mol. Biol. | pmid:20707929 |
| Yap WN et al. | Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. | 2008 | Br. J. Cancer | pmid:19002171 |
| Prasad S et al. | γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. | 2016 | Br. J. Cancer | pmid:27575851 |
| Sun W et al. | Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. | 2008 | Br. J. Nutr. | pmid:18081943 |
| Rajendran P et al. | γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. | 2011 | Br. J. Pharmacol. | pmid:21198544 |
| Hermizi H et al. | Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation. | 2009 | Calcif. Tissue Int. | pmid:19020790 |
| Yap WN et al. | Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. | 2010 | Cancer Lett. | pmid:19926394 |
| Tuerdi G et al. | Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. | 2013 | Cancer Lett. | pmid:23879968 |
| Gopalan A et al. | Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. | 2013 | Cancer Lett. | pmid:23063651 |
| Kunnumakkara AB et al. | {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. | 2010 | Cancer Res. | pmid:20864511 |
| Samant GV et al. | Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression. | 2010 | Cell Prolif. | pmid:19922488 |
| Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
| Samant GV and Sylvester PW | gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. | 2006 | Cell Prolif. | pmid:17109639 |
| Ayoub NM et al. | γ-Tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells. | 2011 | Cell Prolif. | pmid:21973114 |
| Ayoub NM et al. | Combined γ-tocotrienol and Met inhibitor treatment suppresses mammary cancer cell proliferation, epithelial-to-mesenchymal transition and migration. | 2013 | Cell Prolif. | pmid:24033536 |
| Loganathan R et al. | Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. | 2013 | Cell Prolif. | pmid:23510475 |
| Tan SW et al. | Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. | 2011 | Cell. Immunol. | pmid:21839427 |
| Then SM et al. | Is vitamin E toxic to neuron cells? | 2009 | Cell. Mol. Neurobiol. | pmid:19172392 |
| Manu KA et al. | First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. | 2012 | Clin. Cancer Res. | pmid:22351692 |
| Newaz MA and Nawal NN | Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). | 1999 | Clin. Exp. Hypertens. | pmid:10574414 |
| Makpol S et al. | Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. | 2012 | Clinics (Sao Paulo) | pmid:22358238 |
| Ong FB et al. | Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:7903615 |
| Kulkarni S et al. | Hematological targets of radiation damage. | 2010 | Curr Drug Targets | pmid:20583980 |
| Berbée M and Hauer-Jensen M | Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? | 2012 | Curr Opin Support Palliat Care | pmid:22228028 |
| Wilankar C et al. | γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways. | 2011 | Curr. Pharm. Des. | pmid:21774779 |
| Kulkarni S et al. | Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure. | 2013 | Cytokine | pmid:23561424 |
| Abuasal B et al. | Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. | 2010 | Drug Metab. Dispos. | pmid:20207946 |
| Akaho N et al. | Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. | 2007 | Drug Metab. Dispos. | pmid:17537874 |
| Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
| Shah SJ and Sylvester PW | Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. | 2005 | Exp. Biol. Med. (Maywood) | pmid:15792944 |
| Tiwari RV et al. | γ-Tocotrienol-induced autophagy in malignant mammary cancer cells. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24231340 |