| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
gamma-tocotrienol
Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol
PubChem Biomolecular Interactions and Pathways
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All references with gamma-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bi S et al. | gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. | 2010 Jul-Aug | Toxicology | pmid:20452389 |
| Meganathan P et al. | A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects. | 2015 | Sci Rep | pmid:26323969 |
| Berbée M et al. | gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. | 2009 | Radiat. Res. | pmid:19580495 |
| Kulkarni S et al. | Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. | 2010 | Radiat. Res. | pmid:20518653 |
| Berbée M et al. | Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. | 2011 | Radiat. Res. | pmid:21388273 |
| Jiang Q et al. | Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19074288 |
| Eugeni Piller L et al. | Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21844348 |
| Mène-Saffrané L et al. | Plastochromanol-8 and tocopherols are essential lipid-soluble antioxidants during seed desiccation and quiescence in Arabidopsis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20837525 |
| Szymańska R and Kruk J | [Occurrence and function of tocochromanols in plants, animals and men]. | 2007 | Postepy Biochem. | pmid:17969879 |
| Szymańska R | [Chloroplast prenylated lipids in response to stress in plants]. | 2012 | Postepy Biochem. | pmid:23662431 |
| Rodzian MN et al. | Pure tocotrienol concentrate protected rat gastric mucosa from acute stress-induced injury by a non-antioxidant mechanism. | 2013 | Pol J Pathol | pmid:23625601 |
| Zhang JS et al. | γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. | 2013 | PLoS ONE | pmid:23469066 |
| Dłużewska J et al. | Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. | 2016 | PLoS ONE | pmid:27462710 |
| Singh VK et al. | Progenitors mobilized by gamma-tocotrienol as an effective radiation countermeasure. | 2014 | PLoS ONE | pmid:25423021 |
| Akl MR et al. | Mechanisms mediating the synergistic anticancer effects of combined γ-tocotrienol and sesamin treatment. | 2012 | Planta Med. | pmid:22987298 |
| Martinis J et al. | A chloroplast ABC1-like kinase regulates vitamin E metabolism in Arabidopsis. | 2013 | Plant Physiol. | pmid:23632854 |
| Kim EH et al. | Fibrillin 5 Is Essential for Plastoquinone-9 Biosynthesis by Binding to Solanesyl Diphosphate Synthases in Arabidopsis. | 2015 | Plant Cell | pmid:26432861 |
| Yap WN et al. | Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. | 2010 | Pigment Cell Melanoma Res | pmid:20609176 |
| Nakashima K et al. | The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. | 2010 | Phytother Res | pmid:20127663 |
| Kaup RM et al. | Antidiabetic effects of a standardized Egyptian rice bran extract. | 2013 | Phytother Res | pmid:22566008 |
| Yap WN et al. | In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer. | 2010 | Pharmacology | pmid:20375535 |
| Makpol S et al. | Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts. | 2012 | Oxid Med Cell Longev | pmid:22919441 |
| Makpol S et al. | Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis. | 2013 | Oxid Med Cell Longev | pmid:23634235 |
| Makpol S et al. | gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716926 |
| Siveen KS et al. | Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model. | 2014 | Oncotarget | pmid:24722367 |
| Xu WL et al. | Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. | 2009 | Nutrition | pmid:19121919 |
| Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
| Inoue A et al. | Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway. | 2011 | Nutr Cancer | pmid:21660856 |
| Chang PN et al. | Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. | 2009 | Nutr Cancer | pmid:19373609 |
| Zhao L et al. | Regulation of Obesity and Metabolic Complications by Gamma and Delta Tocotrienols. | 2016 | Molecules | pmid:26978344 |
| Yusof KM et al. | γ-Tocotrienol and 6-Gingerol in Combination Synergistically Induce Cytotoxicity and Apoptosis in HT-29 and SW837 Human Colorectal Cancer Cells. | 2015 | Molecules | pmid:26046324 |
| Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
| Kamat JP et al. | Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. | 1997 | Mol. Cell. Biochem. | pmid:9144327 |
| Das S et al. | Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. | 2012 | Mol. Cell. Biochem. | pmid:21918828 |
| Kannappan R et al. | Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. | 2010 | Mol. Cancer Ther. | pmid:20682650 |
| Gopalan A et al. | Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:23065795 |
| Xiong A et al. | Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:22707267 |
| Matsunaga T et al. | γ-Tocotrienol attenuates TNF-α-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. | 2012 | Mol Med Rep | pmid:22293775 |
| Wong RS et al. | δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells. | 2012 | Microsc. Microanal. | pmid:22640960 |
| Rajikin MH et al. | Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol. | 2009 | Med. Sci. Monit. | pmid:19946227 |
| Kamsani YS et al. | Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice. | 2013 | Med Sci Monit Basic Res | pmid:23462735 |
| Deng L et al. | Tissue distribution of emulsified γ-tocotrienol and its long-term biological effects after subcutaneous administration. | 2014 | Lipids Health Dis | pmid:24712339 |
| Tsuzuki W et al. | Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol. | 2007 | Lipids | pmid:17393222 |
| Wali VB and Sylvester PW | Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. | 2007 | Lipids | pmid:17701065 |
| Uchida T et al. | Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol. | 2012 | Lipids | pmid:22042641 |
| Abuasal BS et al. | Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. | 2012 | Lipids | pmid:22271424 |
| Watkins T et al. | gamma-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. | 1993 | Lipids | pmid:8121254 |
| Qureshi AA et al. | Response of hypercholesterolemic subjects to administration of tocotrienols. | 1995 | Lipids | pmid:8614309 |
| Tomeo AC et al. | Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. | 1995 | Lipids | pmid:8614310 |
| Nakagawa K et al. | gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. | 2010 | Lipids | pmid:20714817 |
| Wali VB et al. | Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | 2009 | Lipids | pmid:19777282 |
| Pierpaoli E et al. | Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. | 2010 | Life Sci. | pmid:20188744 |
| Kumar KS et al. | Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. | 2006 | Life Sci. | pmid:16413038 |
| Ding Y et al. | Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27864002 |
| Sylvester PW et al. | Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. | 2005 | J. Plant Physiol. | pmid:16008108 |
| Newaz MA et al. | Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol. | 2003 | J. Physiol. Pharmacol. | pmid:14566071 |
| Nowak G et al. | γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22040679 |
| Yap SP et al. | Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. | 2001 | J. Pharm. Pharmacol. | pmid:11206194 |
| Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
| Couladouros EA et al. | A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols. | 2007 | J. Org. Chem. | pmid:17685653 |
| Uchida T et al. | Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:22293209 |
| Burdeos GC et al. | γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. | 2013 | J. Nutr. Sci. Vitaminol. | pmid:23727646 |
| Wang Y et al. | Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells. | 2012 | J. Nutr. Biochem. | pmid:21764283 |
| Xu W et al. | γ-Tocotrienol inhibits cell viability through suppression of β-catenin/Tcf signaling in human colon carcinoma HT-29 cells. | 2012 | J. Nutr. Biochem. | pmid:21852086 |
| Sun W et al. | gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. | 2009 | J. Nutr. Biochem. | pmid:18602811 |
| Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
| Wang Y and Jiang Q | γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophages. | 2013 | J. Nutr. Biochem. | pmid:23246159 |
| Hiura Y et al. | Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo. | 2009 | J. Nutr. Biochem. | pmid:18824342 |
| Jang Y et al. | Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. | 2017 | J. Nutr. Biochem. | pmid:28456081 |
| Patacsil D et al. | Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. | 2012 | J. Nutr. Biochem. | pmid:21429729 |
| Li Y et al. | γ-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell. | 2011 | J. Nutr. Biochem. | pmid:21292465 |
| Miyoshi N et al. | The enhancement of the oral bioavailability of γ-tocotrienol in mice by γ-cyclodextrin inclusion. | 2011 | J. Nutr. Biochem. | pmid:21292469 |
| Liu HK et al. | Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. | 2010 | J. Nutr. Biochem. | pmid:19195866 |
| Guthrie N et al. | Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. | 1997 | J. Nutr. | pmid:9082043 |
| Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
| Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
| Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
| Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
| Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
| Qureshi AA et al. | Dietary alpha-tocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens. | 1996 | J. Nutr. | pmid:8632210 |
| He L et al. | Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. | 1997 | J. Nutr. | pmid:9164984 |
| Mo H and Elson CE | Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. | 1999 | J. Nutr. | pmid:10203554 |
| Freiser H and Jiang Q | Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats. | 2009 | J. Nutr. | pmid:19297424 |
| Mazlan M et al. | Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. | 2006 | J. Neurol. Sci. | pmid:16442562 |
| Nikolic K and Agababa D | Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells. | 2009 | J. Mol. Graph. Model. | pmid:19117779 |
| Kim Y et al. | Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. | 2016 | J. Lipid Res. | pmid:26628639 |
| Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
| Mangialasche F et al. | Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol. | 2013 | J. Intern. Med. | pmid:23343471 |
| Peh HY et al. | Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma. | 2015 | J. Immunol. | pmid:26041537 |
| Mao Y et al. | Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. | 2017 | J. Food Sci. | pmid:28135396 |
| Mukhopadhyay P et al. | Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol. | 2012 | J. Cell. Mol. Med. | pmid:22050707 |
| Lekli I et al. | Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. | 2010 | J. Cell. Mol. Med. | pmid:19799646 |
| Shuid AN et al. | Vitamin E exhibits bone anabolic actions in normal male rats. | 2010 | J. Bone Miner. Metab. | pmid:19779668 |
| Ahn KS et al. | Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | 2007 | J. Biol. Chem. | pmid:17114179 |
| Block A et al. | Functional modeling identifies paralogous solanesyl-diphosphate synthases that assemble the side chain of plastoquinone-9 in plastids. | 2013 | J. Biol. Chem. | pmid:23913686 |
| Strenkert D et al. | Genetically Programmed Changes in Photosynthetic Cofactor Metabolism in Copper-deficient Chlamydomonas. | 2016 | J. Biol. Chem. | pmid:27440043 |
| Song BL and DeBose-Boyd RA | Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. | 2006 | J. Biol. Chem. | pmid:16831864 |
| Parker RA et al. | Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1993 | J. Biol. Chem. | pmid:8388388 |
| Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
| Kannappan R et al. | γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. | 2010 | J. Biol. Chem. | pmid:20720018 |