MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.
We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Theriault A et al. | Effects of gamma-tocotrienol on ApoB synthesis, degradation, and secretion in HepG2 cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073977 |
Mo H and Elson CE | Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. | 1999 | J. Nutr. | pmid:10203554 |
Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
Newaz MA and Nawal NN | Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). | 1999 | Clin. Exp. Hypertens. | pmid:10574414 |
Katsanidis E and Addis PB | Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. | 1999 | Free Radic. Biol. Med. | pmid:10641704 |
Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
Goffman FD and Möllers C | Changes in tocopherol and plastochromanol-8 contents in seeds and oil of oilseed rape (Brassica napus L.) during storage as influenced by temperature and air oxygen. | 2000 | J. Agric. Food Chem. | pmid:10820066 |
Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
Hattori A et al. | Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats. | 2000 | Biol. Pharm. Bull. | pmid:11085376 |
Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
Yap SP et al. | Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. | 2001 | J. Pharm. Pharmacol. | pmid:11206194 |
Nakamura H et al. | Oral toxicity of a tocotrienol preparation in rats. | 2001 | Food Chem. Toxicol. | pmid:11434987 |
Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
Raederstorff D et al. | Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters. | 2002 | Ann. Nutr. Metab. | pmid:11914511 |
Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
Newaz MA et al. | Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol. | 2003 | J. Physiol. Pharmacol. | pmid:14566071 |
Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
Shah SJ and Sylvester PW | Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. | 2005 | Biochem. Cell Biol. | pmid:15746970 |
Conte C et al. | Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753178 |
Shah SJ and Sylvester PW | Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. | 2005 | Exp. Biol. Med. (Maywood) | pmid:15792944 |
Sylvester PW et al. | Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. | 2005 | J. Plant Physiol. | pmid:16008108 |
Kumar KS et al. | Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. | 2006 | Life Sci. | pmid:16413038 |
Mazlan M et al. | Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. | 2006 | J. Neurol. Sci. | pmid:16442562 |
Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
Song BL and DeBose-Boyd RA | Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. | 2006 | J. Biol. Chem. | pmid:16831864 |
Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
Samant GV and Sylvester PW | gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. | 2006 | Cell Prolif. | pmid:17109639 |
Ahn KS et al. | Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | 2007 | J. Biol. Chem. | pmid:17114179 |
Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
Kawakami Y et al. | Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284857 |
Tsuzuki W et al. | Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol. | 2007 | Lipids | pmid:17393222 |
Akaho N et al. | Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. | 2007 | Drug Metab. Dispos. | pmid:17537874 |
Couladouros EA et al. | A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols. | 2007 | J. Org. Chem. | pmid:17685653 |
Wali VB and Sylvester PW | Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. | 2007 | Lipids | pmid:17701065 |
Szymańska R and Kruk J | [Occurrence and function of tocochromanols in plants, animals and men]. | 2007 | Postepy Biochem. | pmid:17969879 |
Sun W et al. | Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. | 2008 | Br. J. Nutr. | pmid:18081943 |
Sun W et al. | gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. | 2009 | J. Nutr. Biochem. | pmid:18602811 |
Hsieh TC and Wu JM | Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. | 2008 | Int. J. Oncol. | pmid:18813800 |
Hiura Y et al. | Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo. | 2009 | J. Nutr. Biochem. | pmid:18824342 |
Yap WN et al. | Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. | 2008 | Br. J. Cancer | pmid:19002171 |
Hermizi H et al. | Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation. | 2009 | Calcif. Tissue Int. | pmid:19020790 |
Jiang Q et al. | Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19074288 |
Nikolic K and Agababa D | Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells. | 2009 | J. Mol. Graph. Model. | pmid:19117779 |
Xu WL et al. | Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. | 2009 | Nutrition | pmid:19121919 |
Then SM et al. | Is vitamin E toxic to neuron cells? | 2009 | Cell. Mol. Neurobiol. | pmid:19172392 |
Liu HK et al. | Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. | 2010 | J. Nutr. Biochem. | pmid:19195866 |
Freiser H and Jiang Q | Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats. | 2009 | J. Nutr. | pmid:19297424 |
Wali VB et al. | Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. | 2009 | Exp. Biol. Med. (Maywood) | pmid:19359655 |
Chang PN et al. | Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. | 2009 | Nutr Cancer | pmid:19373609 |
Ghosh SP et al. | Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. | 2009 | Int. J. Radiat. Biol. | pmid:19557601 |
Berbée M et al. | gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. | 2009 | Radiat. Res. | pmid:19580495 |
Yang Z et al. | Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. | 2010 | Int. J. Cancer | pmid:19626588 |
Wali VB et al. | Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. | 2009 | Apoptosis | pmid:19771520 |
Wali VB et al. | Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | 2009 | Lipids | pmid:19777282 |
Shuid AN et al. | Vitamin E exhibits bone anabolic actions in normal male rats. | 2010 | J. Bone Miner. Metab. | pmid:19779668 |
Lekli I et al. | Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. | 2010 | J. Cell. Mol. Med. | pmid:19799646 |
Zbierzak AM et al. | Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. | 2010 | Biochem. J. | pmid:19843012 |
Samant GV et al. | Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression. | 2010 | Cell Prolif. | pmid:19922488 |
Yap WN et al. | Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. | 2010 | Cancer Lett. | pmid:19926394 |
Rajikin MH et al. | Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol. | 2009 | Med. Sci. Monit. | pmid:19946227 |
Shirode AB and Sylvester PW | Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. | 2010 | Biomed. Pharmacother. | pmid:19954924 |
Qureshi AA et al. | Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). | 1991 | Am. J. Clin. Nutr. | pmid:2012010 |
Nakashima K et al. | The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. | 2010 | Phytother Res | pmid:20127663 |
Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
Pierpaoli E et al. | Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. | 2010 | Life Sci. | pmid:20188744 |
Abuasal B et al. | Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. | 2010 | Drug Metab. Dispos. | pmid:20207946 |
Bachawal SV et al. | Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. | 2010 | BMC Cancer | pmid:20211018 |
Bachawal SV et al. | Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. | 2010 | Anticancer Res. | pmid:20332450 |
Yap WN et al. | In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer. | 2010 | Pharmacology | pmid:20375535 |
Bi S et al. | gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. | 2010 Jul-Aug | Toxicology | pmid:20452389 |
Shibata A et al. | Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. | 2010 | J. Agric. Food Chem. | pmid:20465215 |
pmid:20499024 | ||||
Kulkarni S et al. | Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. | 2010 | Radiat. Res. | pmid:20518653 |
Kulkarni S et al. | Hematological targets of radiation damage. | 2010 | Curr Drug Targets | pmid:20583980 |
Yap WN et al. | Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. | 2010 | Pigment Cell Melanoma Res | pmid:20609176 |
Luk SU et al. | Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. | 2011 | Int. J. Cancer | pmid:20617516 |
Kannappan R et al. | Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. | 2010 | Mol. Cancer Ther. | pmid:20682650 |
Hsieh TC et al. | gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells. | 2010 | Anticancer Res. | pmid:20683025 |
Zaiden N et al. | Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. | 2010 | J. Atheroscler. Thromb. | pmid:20702976 |
Zainuddin A et al. | Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts. | 2010 | BMC Mol. Biol. | pmid:20707929 |
Nakagawa K et al. | gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. | 2010 | Lipids | pmid:20714817 |
Makpol S et al. | gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. | 2010 Jan-Feb | Oxid Med Cell Longev | pmid:20716926 |
Kannappan R et al. | γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. | 2010 | J. Biol. Chem. | pmid:20720018 |
Abuasal B et al. | Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. | 2011 | Biomed. Chromatogr. | pmid:20734323 |
Mène-Saffrané L et al. | Plastochromanol-8 and tocopherols are essential lipid-soluble antioxidants during seed desiccation and quiescence in Arabidopsis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20837525 |
Kunnumakkara AB et al. | {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. | 2010 | Cancer Res. | pmid:20864511 |
Berbee M et al. | Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin. | 2011 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:20950957 |
Rajendran P et al. | γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. | 2011 | Br. J. Pharmacol. | pmid:21198544 |
Li Y et al. | γ-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell. | 2011 | J. Nutr. Biochem. | pmid:21292465 |
Miyoshi N et al. | The enhancement of the oral bioavailability of γ-tocotrienol in mice by γ-cyclodextrin inclusion. | 2011 | J. Nutr. Biochem. | pmid:21292469 |
Campbell SE et al. | γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer. | 2011 | Free Radic. Biol. Med. | pmid:21335085 |
Berbée M et al. | Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. | 2011 | Radiat. Res. | pmid:21388273 |
Jiang Q et al. | Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | 2012 | Int. J. Cancer | pmid:21400505 |