MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.
We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
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Qureshi AA et al. | Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). | 1991 | Am. J. Clin. Nutr. | pmid:2012010 |
Watkins T et al. | gamma-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. | 1993 | Lipids | pmid:8121254 |
Parker RA et al. | Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1993 | J. Biol. Chem. | pmid:8388388 |
Ong FB et al. | Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:7903615 |
Suarna C et al. | Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. | 1993 | Biochim. Biophys. Acta | pmid:8443232 |
Qureshi AA et al. | Response of hypercholesterolemic subjects to administration of tocotrienols. | 1995 | Lipids | pmid:8614309 |
Tomeo AC et al. | Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. | 1995 | Lipids | pmid:8614310 |
Qureshi AA et al. | Dietary alpha-tocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens. | 1996 | J. Nutr. | pmid:8632210 |
Guthrie N et al. | Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. | 1997 | J. Nutr. | pmid:9082043 |
Kamat JP et al. | Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. | 1997 | Mol. Cell. Biochem. | pmid:9144327 |
Makpol S et al. | Different starting times of alpha-tocopherol and gamma-tocotrienol supplementation and tumor marker enzyme activities in the rat chemically induced with cancer. | 1997 | Gen. Pharmacol. | pmid:9147029 |
He L et al. | Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. | 1997 | J. Nutr. | pmid:9164984 |
Wang Q et al. | Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618265 |
Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
Katsanidis E and Addis PB | Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. | 1999 | Free Radic. Biol. Med. | pmid:10641704 |
Mo H and Elson CE | Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. | 1999 | J. Nutr. | pmid:10203554 |
Theriault A et al. | Effects of gamma-tocotrienol on ApoB synthesis, degradation, and secretion in HepG2 cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073977 |
Newaz MA and Nawal NN | Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). | 1999 | Clin. Exp. Hypertens. | pmid:10574414 |
Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
Goffman FD and Möllers C | Changes in tocopherol and plastochromanol-8 contents in seeds and oil of oilseed rape (Brassica napus L.) during storage as influenced by temperature and air oxygen. | 2000 | J. Agric. Food Chem. | pmid:10820066 |
Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
Hattori A et al. | Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats. | 2000 | Biol. Pharm. Bull. | pmid:11085376 |
Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
Nakamura H et al. | Oral toxicity of a tocotrienol preparation in rats. | 2001 | Food Chem. Toxicol. | pmid:11434987 |
Yap SP et al. | Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. | 2001 | J. Pharm. Pharmacol. | pmid:11206194 |
Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
Raederstorff D et al. | Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters. | 2002 | Ann. Nutr. Metab. | pmid:11914511 |
Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
Newaz MA et al. | Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol. | 2003 | J. Physiol. Pharmacol. | pmid:14566071 |
Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
Conte C et al. | Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753178 |
Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
Shah SJ and Sylvester PW | Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. | 2005 | Exp. Biol. Med. (Maywood) | pmid:15792944 |
Shah SJ and Sylvester PW | Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. | 2005 | Biochem. Cell Biol. | pmid:15746970 |
Sylvester PW et al. | Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. | 2005 | J. Plant Physiol. | pmid:16008108 |
Mazlan M et al. | Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. | 2006 | J. Neurol. Sci. | pmid:16442562 |
Samant GV and Sylvester PW | gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. | 2006 | Cell Prolif. | pmid:17109639 |
Kumar KS et al. | Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. | 2006 | Life Sci. | pmid:16413038 |
Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
Song BL and DeBose-Boyd RA | Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. | 2006 | J. Biol. Chem. | pmid:16831864 |
Szymańska R and Kruk J | [Occurrence and function of tocochromanols in plants, animals and men]. | 2007 | Postepy Biochem. | pmid:17969879 |
Tsuzuki W et al. | Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol. | 2007 | Lipids | pmid:17393222 |
Kawakami Y et al. | Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284857 |
Akaho N et al. | Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. | 2007 | Drug Metab. Dispos. | pmid:17537874 |
Wali VB and Sylvester PW | Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. | 2007 | Lipids | pmid:17701065 |
Ahn KS et al. | Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | 2007 | J. Biol. Chem. | pmid:17114179 |
Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
Couladouros EA et al. | A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols. | 2007 | J. Org. Chem. | pmid:17685653 |
Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
Jiang Q et al. | Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19074288 |
Yap WN et al. | Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. | 2008 | Br. J. Cancer | pmid:19002171 |
Sun W et al. | Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. | 2008 | Br. J. Nutr. | pmid:18081943 |
Hsieh TC and Wu JM | Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. | 2008 | Int. J. Oncol. | pmid:18813800 |
Ghosh SP et al. | Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. | 2009 | Int. J. Radiat. Biol. | pmid:19557601 |
Rajikin MH et al. | Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol. | 2009 | Med. Sci. Monit. | pmid:19946227 |
Sun W et al. | gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. | 2009 | J. Nutr. Biochem. | pmid:18602811 |
Hiura Y et al. | Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo. | 2009 | J. Nutr. Biochem. | pmid:18824342 |
Chang PN et al. | Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. | 2009 | Nutr Cancer | pmid:19373609 |