| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
Total
1
gamma-tocotrienol
Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for gamma-tocotrienol
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol
PubChem Biomolecular Interactions and Pathways
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All references with gamma-tocotrienol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bachawal SV et al. | Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. | 2010 | Anticancer Res. | pmid:20332450 |
| Bachawal SV et al. | Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. | 2010 | BMC Cancer | pmid:20211018 |
| Zbierzak AM et al. | Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. | 2010 | Biochem. J. | pmid:19843012 |
| Samant GV et al. | Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression. | 2010 | Cell Prolif. | pmid:19922488 |
| Yap WN et al. | Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. | 2010 | Cancer Lett. | pmid:19926394 |
| Shirode AB and Sylvester PW | Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. | 2010 | Biomed. Pharmacother. | pmid:19954924 |
| Shibata A et al. | Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. | 2010 | J. Agric. Food Chem. | pmid:20465215 |
| Kulkarni S et al. | Hematological targets of radiation damage. | 2010 | Curr Drug Targets | pmid:20583980 |
| Kulkarni S et al. | Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. | 2010 | Radiat. Res. | pmid:20518653 |
| Nakashima K et al. | The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. | 2010 | Phytother Res | pmid:20127663 |
| Li F et al. | Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. | 2010 | Atherosclerosis | pmid:20138624 |
| Yang Z et al. | Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. | 2010 | Int. J. Cancer | pmid:19626588 |
| Zaiden N et al. | Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. | 2010 | J. Atheroscler. Thromb. | pmid:20702976 |
| Lekli I et al. | Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. | 2010 | J. Cell. Mol. Med. | pmid:19799646 |
| Zainuddin A et al. | Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts. | 2010 | BMC Mol. Biol. | pmid:20707929 |
| Kannappan R et al. | γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. | 2010 | J. Biol. Chem. | pmid:20720018 |
| Kannappan R et al. | Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. | 2010 | Mol. Cancer Ther. | pmid:20682650 |
| Hsieh TC et al. | gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells. | 2010 | Anticancer Res. | pmid:20683025 |
| Mène-Saffrané L et al. | Plastochromanol-8 and tocopherols are essential lipid-soluble antioxidants during seed desiccation and quiescence in Arabidopsis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20837525 |
| Kunnumakkara AB et al. | {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. | 2010 | Cancer Res. | pmid:20864511 |
| Liu HK et al. | Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. | 2010 | J. Nutr. Biochem. | pmid:19195866 |
| Hermizi H et al. | Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation. | 2009 | Calcif. Tissue Int. | pmid:19020790 |
| Xu WL et al. | Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. | 2009 | Nutrition | pmid:19121919 |
| Berbée M et al. | gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. | 2009 | Radiat. Res. | pmid:19580495 |
| Ghosh SP et al. | Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. | 2009 | Int. J. Radiat. Biol. | pmid:19557601 |
| Rajikin MH et al. | Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol. | 2009 | Med. Sci. Monit. | pmid:19946227 |
| Sun W et al. | gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. | 2009 | J. Nutr. Biochem. | pmid:18602811 |
| Hiura Y et al. | Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo. | 2009 | J. Nutr. Biochem. | pmid:18824342 |
| Chang PN et al. | Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. | 2009 | Nutr Cancer | pmid:19373609 |
| Then SM et al. | Is vitamin E toxic to neuron cells? | 2009 | Cell. Mol. Neurobiol. | pmid:19172392 |
| Freiser H and Jiang Q | Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats. | 2009 | J. Nutr. | pmid:19297424 |
| Wali VB et al. | Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. | 2009 | Exp. Biol. Med. (Maywood) | pmid:19359655 |
| Nikolic K and Agababa D | Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells. | 2009 | J. Mol. Graph. Model. | pmid:19117779 |
| Wali VB et al. | Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. | 2009 | Apoptosis | pmid:19771520 |
| Wali VB et al. | Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | 2009 | Lipids | pmid:19777282 |
| Jiang Q et al. | Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19074288 |
| Yap WN et al. | Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. | 2008 | Br. J. Cancer | pmid:19002171 |
| Sun W et al. | Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. | 2008 | Br. J. Nutr. | pmid:18081943 |
| Hsieh TC and Wu JM | Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. | 2008 | Int. J. Oncol. | pmid:18813800 |
| Szymańska R and Kruk J | [Occurrence and function of tocochromanols in plants, animals and men]. | 2007 | Postepy Biochem. | pmid:17969879 |
| Tsuzuki W et al. | Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol. | 2007 | Lipids | pmid:17393222 |
| Kawakami Y et al. | Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284857 |
| Akaho N et al. | Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. | 2007 | Drug Metab. Dispos. | pmid:17537874 |
| Wali VB and Sylvester PW | Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. | 2007 | Lipids | pmid:17701065 |
| Ahn KS et al. | Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | 2007 | J. Biol. Chem. | pmid:17114179 |
| Abe C et al. | Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. | 2007 | J. Nutr. | pmid:17237309 |
| Couladouros EA et al. | A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols. | 2007 | J. Org. Chem. | pmid:17685653 |
| Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
| Mazlan M et al. | Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. | 2006 | J. Neurol. Sci. | pmid:16442562 |
| Samant GV and Sylvester PW | gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. | 2006 | Cell Prolif. | pmid:17109639 |
| Kumar KS et al. | Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. | 2006 | Life Sci. | pmid:16413038 |
| Sakai M et al. | Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | 2006 | J. Nutr. Biochem. | pmid:16517139 |
| Song BL and DeBose-Boyd RA | Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. | 2006 | J. Biol. Chem. | pmid:16831864 |
| Shah SJ and Sylvester PW | Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. | 2005 | Exp. Biol. Med. (Maywood) | pmid:15792944 |
| Shah SJ and Sylvester PW | Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells. | 2005 | Biochem. Cell Biol. | pmid:15746970 |
| Sylvester PW et al. | Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells. | 2005 | J. Plant Physiol. | pmid:16008108 |
| Yap SP and Yuen KH | Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. | 2004 | Int J Pharm | pmid:15288344 |
| Conte C et al. | Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753178 |
| Zhou C et al. | Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. | 2004 | Drug Metab. Dispos. | pmid:15269186 |
| Yap SP et al. | Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. | 2003 | J. Pharm. Pharmacol. | pmid:12625867 |
| Fuchs J et al. | HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. | 2003 | Free Radic. Biol. Med. | pmid:12543248 |
| Ikeda S et al. | Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. | 2003 | J. Nutr. | pmid:12566479 |
| Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
| Newaz MA et al. | Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol. | 2003 | J. Physiol. Pharmacol. | pmid:14566071 |
| Mustad VA et al. | Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. | 2002 | Am. J. Clin. Nutr. | pmid:12450888 |
| Raederstorff D et al. | Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters. | 2002 | Ann. Nutr. Metab. | pmid:11914511 |
| Qureshi AA et al. | Novel tocotrienols of rice bran suppress cholesterogenesis in hereditary hypercholesterolemic swine. | 2001 | J. Nutr. | pmid:11160537 |
| Ikeda S et al. | Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | 2001 | J. Nutr. | pmid:11694614 |
| Sylvester PW et al. | Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. | 2001 | Cell Prolif. | pmid:11736999 |
| Nakamura H et al. | Oral toxicity of a tocotrienol preparation in rats. | 2001 | Food Chem. Toxicol. | pmid:11434987 |
| Yap SP et al. | Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. | 2001 | J. Pharm. Pharmacol. | pmid:11206194 |
| Black TM et al. | Palm tocotrienols protect ApoE +/- mice from diet-induced atheroma formation. | 2000 | J. Nutr. | pmid:11015467 |
| Goffman FD and Möllers C | Changes in tocopherol and plastochromanol-8 contents in seeds and oil of oilseed rape (Brassica napus L.) during storage as influenced by temperature and air oxygen. | 2000 | J. Agric. Food Chem. | pmid:10820066 |
| Sen CK et al. | Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. | 2000 | J. Biol. Chem. | pmid:10777609 |
| Hattori A et al. | Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats. | 2000 | Biol. Pharm. Bull. | pmid:11085376 |
| Yu W et al. | Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. | 1999 | Nutr Cancer | pmid:10227040 |
| Katsanidis E and Addis PB | Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. | 1999 | Free Radic. Biol. Med. | pmid:10641704 |
| Mo H and Elson CE | Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. | 1999 | J. Nutr. | pmid:10203554 |
| Theriault A et al. | Effects of gamma-tocotrienol on ApoB synthesis, degradation, and secretion in HepG2 cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073977 |
| Newaz MA and Nawal NN | Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). | 1999 | Clin. Exp. Hypertens. | pmid:10574414 |
| Wang Q et al. | Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618265 |
| Guthrie N et al. | Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. | 1997 | J. Nutr. | pmid:9082043 |
| Kamat JP et al. | Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. | 1997 | Mol. Cell. Biochem. | pmid:9144327 |
| Makpol S et al. | Different starting times of alpha-tocopherol and gamma-tocotrienol supplementation and tumor marker enzyme activities in the rat chemically induced with cancer. | 1997 | Gen. Pharmacol. | pmid:9147029 |
| He L et al. | Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. | 1997 | J. Nutr. | pmid:9164984 |
| Qureshi AA et al. | Dietary alpha-tocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens. | 1996 | J. Nutr. | pmid:8632210 |
| Qureshi AA et al. | Response of hypercholesterolemic subjects to administration of tocotrienols. | 1995 | Lipids | pmid:8614309 |
| Tomeo AC et al. | Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. | 1995 | Lipids | pmid:8614310 |
| Watkins T et al. | gamma-Tocotrienol as a hypocholesterolemic and antioxidant agent in rats fed atherogenic diets. | 1993 | Lipids | pmid:8121254 |
| Parker RA et al. | Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 1993 | J. Biol. Chem. | pmid:8388388 |
| Ong FB et al. | Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:7903615 |
| Suarna C et al. | Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins. | 1993 | Biochim. Biophys. Acta | pmid:8443232 |
| Qureshi AA et al. | Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). | 1991 | Am. J. Clin. Nutr. | pmid:2012010 |
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