gamma-tocotrienol

Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for gamma-tocotrienol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with gamma-tocotrienol

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Authors Title Published Journal PubMed Link
Zhang JS et al. γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. 2013 PLoS ONE pmid:23469066
Ray S et al. Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure. 2013 Int. Immunopharmacol. pmid:23415908
Tuerdi G et al. Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. 2013 Cancer Lett. pmid:23879968
Nowak G et al. γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death. 2012 J. Pharmacol. Exp. Ther. pmid:22040679
Wang Y et al. Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells. 2012 J. Nutr. Biochem. pmid:21764283
Xu W et al. γ-Tocotrienol inhibits cell viability through suppression of β-catenin/Tcf signaling in human colon carcinoma HT-29 cells. 2012 J. Nutr. Biochem. pmid:21852086
Matsunaga T et al. γ-Tocotrienol attenuates TNF-α-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. 2012 Mol Med Rep pmid:22293775
Mukhopadhyay P et al. Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol. 2012 J. Cell. Mol. Med. pmid:22050707
Uchida T et al. Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol. 2012 Lipids pmid:22042641
Das S et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. 2012 Mol. Cell. Biochem. pmid:21918828
Abuasal BS et al. Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. 2012 Lipids pmid:22271424
Makpol S et al. Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts. 2012 Oxid Med Cell Longev pmid:22919441
Berbée M and Hauer-Jensen M Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? 2012 Curr Opin Support Palliat Care pmid:22228028
Fukui K et al. Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells. 2012 Free Radic. Res. pmid:22149330
Manu KA et al. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 2012 Clin. Cancer Res. pmid:22351692
Wong RS et al. δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells. 2012 Microsc. Microanal. pmid:22640960
Makpol S et al. Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. 2012 Clinics (Sao Paulo) pmid:22358238
Szymańska R [Chloroplast prenylated lipids in response to stress in plants]. 2012 Postepy Biochem. pmid:23662431
Akl MR et al. Mechanisms mediating the synergistic anticancer effects of combined γ-tocotrienol and sesamin treatment. 2012 Planta Med. pmid:22987298
Gopalan A et al. Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. 2012 Mol Nutr Food Res pmid:23065795
Kulkarni SS et al. Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor. 2012 Int. Immunopharmacol. pmid:23000517
Krycer JR et al. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. 2012 Biochem. J. pmid:22657538
Xiong A et al. Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. 2012 Mol Nutr Food Res pmid:22707267
Patacsil D et al. Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells. 2012 J. Nutr. Biochem. pmid:21429729
Jiang Q et al. Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. 2012 Int. J. Cancer pmid:21400505
Luk SU et al. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. 2011 Int. J. Cancer pmid:20617516
Wilankar C et al. γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways. 2011 Curr. Pharm. Des. pmid:21774779
Abuznait AH et al. Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products. 2011 Food Chem. Toxicol. pmid:21851848
Eugeni Piller L et al. Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21844348
Wilankar C et al. Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols. 2011 Free Radic. Biol. Med. pmid:21536125
Tan SW et al. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. 2011 Cell. Immunol. pmid:21839427
Uchida T et al. Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol. 2011 J. Nutr. Sci. Vitaminol. pmid:22293209
Ayoub NM et al. γ-Tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells. 2011 Cell Prolif. pmid:21973114
Rajendran P et al. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. 2011 Br. J. Pharmacol. pmid:21198544
Brooks R et al. Direct inhibition of osteoclast formation and activity by the vitamin E isomer gamma-tocotrienol. 2011 Int J Vitam Nutr Res pmid:22673919
Abuasal B et al. Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma. 2011 Biomed. Chromatogr. pmid:20734323
Inoue A et al. Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway. 2011 Nutr Cancer pmid:21660856
Campbell SE et al. γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer. 2011 Free Radic. Biol. Med. pmid:21335085
Berbée M et al. Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. 2011 Radiat. Res. pmid:21388273
Berbee M et al. Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin. 2011 Int. J. Radiat. Oncol. Biol. Phys. pmid:20950957
Li Y et al. γ-Tocotrienol inhibits angiogenesis of human umbilical vein endothelial cell induced by cancer cell. 2011 J. Nutr. Biochem. pmid:21292465
Miyoshi N et al. The enhancement of the oral bioavailability of γ-tocotrienol in mice by γ-cyclodextrin inclusion. 2011 J. Nutr. Biochem. pmid:21292469
Bi S et al. gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line. 2010 Jul-Aug Toxicology pmid:20452389
Makpol S et al. gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. 2010 Jan-Feb Oxid Med Cell Longev pmid:20716926
Yap WN et al. In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer. 2010 Pharmacology pmid:20375535
Abuasal B et al. Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. 2010 Drug Metab. Dispos. pmid:20207946
Pierpaoli E et al. Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. 2010 Life Sci. pmid:20188744
Yap WN et al. Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. 2010 Pigment Cell Melanoma Res pmid:20609176
Nakagawa K et al. gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. 2010 Lipids pmid:20714817
Shuid AN et al. Vitamin E exhibits bone anabolic actions in normal male rats. 2010 J. Bone Miner. Metab. pmid:19779668