gamma-tocotrienol

Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for gamma-tocotrienol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with gamma-tocotrienol

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Authors Title Published Journal PubMed Link
Samant GV et al. Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression. 2010 Cell Prolif. pmid:19922488
Yap WN et al. Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. 2010 Cancer Lett. pmid:19926394
Shirode AB and Sylvester PW Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. 2010 Biomed. Pharmacother. pmid:19954924
Shibata A et al. Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. 2010 J. Agric. Food Chem. pmid:20465215
Kulkarni S et al. Hematological targets of radiation damage. 2010 Curr Drug Targets pmid:20583980
Kulkarni S et al. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. 2010 Radiat. Res. pmid:20518653
Nakashima K et al. The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. 2010 Phytother Res pmid:20127663
Pierpaoli E et al. Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. 2010 Life Sci. pmid:20188744
Li F et al. Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors. 2010 Atherosclerosis pmid:20138624
Yang Z et al. Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. 2010 Int. J. Cancer pmid:19626588
Zaiden N et al. Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. 2010 J. Atheroscler. Thromb. pmid:20702976
Yap WN et al. Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. 2010 Pigment Cell Melanoma Res pmid:20609176
Lekli I et al. Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. 2010 J. Cell. Mol. Med. pmid:19799646
Nakagawa K et al. gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. 2010 Lipids pmid:20714817
Kannappan R et al. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. 2010 J. Biol. Chem. pmid:20720018
Kannappan R et al. Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. 2010 Mol. Cancer Ther. pmid:20682650
Hsieh TC et al. gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells. 2010 Anticancer Res. pmid:20683025
Mène-Saffrané L et al. Plastochromanol-8 and tocopherols are essential lipid-soluble antioxidants during seed desiccation and quiescence in Arabidopsis. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20837525
Kunnumakkara AB et al. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. 2010 Cancer Res. pmid:20864511
Liu HK et al. Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells. 2010 J. Nutr. Biochem. pmid:19195866
Shuid AN et al. Vitamin E exhibits bone anabolic actions in normal male rats. 2010 J. Bone Miner. Metab. pmid:19779668
Hermizi H et al. Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation. 2009 Calcif. Tissue Int. pmid:19020790
Xu WL et al. Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. 2009 Nutrition pmid:19121919
Berbée M et al. gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. 2009 Radiat. Res. pmid:19580495
Ghosh SP et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. 2009 Int. J. Radiat. Biol. pmid:19557601
Rajikin MH et al. Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol. 2009 Med. Sci. Monit. pmid:19946227
Sun W et al. gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. 2009 J. Nutr. Biochem. pmid:18602811
Hiura Y et al. Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo. 2009 J. Nutr. Biochem. pmid:18824342
Chang PN et al. Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. 2009 Nutr Cancer pmid:19373609
Then SM et al. Is vitamin E toxic to neuron cells? 2009 Cell. Mol. Neurobiol. pmid:19172392
Freiser H and Jiang Q Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats. 2009 J. Nutr. pmid:19297424
Wali VB et al. Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. 2009 Exp. Biol. Med. (Maywood) pmid:19359655
Nikolic K and Agababa D Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells. 2009 J. Mol. Graph. Model. pmid:19117779
Wali VB et al. Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. 2009 Apoptosis pmid:19771520
Wali VB et al. Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. 2009 Lipids pmid:19777282
Jiang Q et al. Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:19074288
Yap WN et al. Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. 2008 Br. J. Cancer pmid:19002171
Sun W et al. Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. 2008 Br. J. Nutr. pmid:18081943
Hsieh TC and Wu JM Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. 2008 Int. J. Oncol. pmid:18813800
Szymańska R and Kruk J [Occurrence and function of tocochromanols in plants, animals and men]. 2007 Postepy Biochem. pmid:17969879
Tsuzuki W et al. Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol. 2007 Lipids pmid:17393222
Kawakami Y et al. Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. 2007 Biosci. Biotechnol. Biochem. pmid:17284857
Akaho N et al. Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. 2007 Drug Metab. Dispos. pmid:17537874
Wali VB and Sylvester PW Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. 2007 Lipids pmid:17701065
Ahn KS et al. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. 2007 J. Biol. Chem. pmid:17114179
Abe C et al. Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver. 2007 J. Nutr. pmid:17237309
Couladouros EA et al. A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols. 2007 J. Org. Chem. pmid:17685653
Ung CY et al. In silico prediction of pregnane X receptor activators by machine learning approaches. 2007 Mol. Pharmacol. pmid:17003167
Mazlan M et al. Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. 2006 J. Neurol. Sci. pmid:16442562
Samant GV and Sylvester PW gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. 2006 Cell Prolif. pmid:17109639