gamma-tocotrienol

Gamma-tocotrienol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1076 references associated with gamma-tocotrienol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for gamma-tocotrienol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-tocotrienol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with gamma-tocotrienol

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Authors Title Published Journal PubMed Link
Samant GV et al. Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression. 2010 Cell Prolif. pmid:19922488
Sylvester PW et al. Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. 2001 Cell Prolif. pmid:11736999
Samant GV and Sylvester PW gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. 2006 Cell Prolif. pmid:17109639
Ayoub NM et al. γ-Tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells. 2011 Cell Prolif. pmid:21973114
Loganathan R et al. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. 2013 Cell Prolif. pmid:23510475
Tan SW et al. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. 2011 Cell. Immunol. pmid:21839427
Then SM et al. Is vitamin E toxic to neuron cells? 2009 Cell. Mol. Neurobiol. pmid:19172392
Manu KA et al. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 2012 Clin. Cancer Res. pmid:22351692
Newaz MA and Nawal NN Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). 1999 Clin. Exp. Hypertens. pmid:10574414
Makpol S et al. Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. 2012 Clinics (Sao Paulo) pmid:22358238
Ong FB et al. Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. 1993 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:7903615
Kulkarni S et al. Hematological targets of radiation damage. 2010 Curr Drug Targets pmid:20583980
Berbée M and Hauer-Jensen M Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? 2012 Curr Opin Support Palliat Care pmid:22228028
Wilankar C et al. γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways. 2011 Curr. Pharm. Des. pmid:21774779
Kulkarni S et al. Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure. 2013 Cytokine pmid:23561424
Abuasal B et al. Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. 2010 Drug Metab. Dispos. pmid:20207946
Akaho N et al. Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat. 2007 Drug Metab. Dispos. pmid:17537874
Zhou C et al. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. 2004 Drug Metab. Dispos. pmid:15269186
Shah SJ and Sylvester PW Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. 2005 Exp. Biol. Med. (Maywood) pmid:15792944
Tiwari RV et al. γ-Tocotrienol-induced autophagy in malignant mammary cancer cells. 2014 Exp. Biol. Med. (Maywood) pmid:24231340