Gamma-tocopherol is a lipid of Prenol Lipids (PR) class. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Adverse effects, Longterm Effects, Luteal Phase and Drug Interactions. Gamma-tocopherol often locates in Blood. The related lipids are Total cholesterol.
To understand associated biological information of gamma-tocopherol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-tocopherol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:12949843 | ||||
| pmid: | ||||
| Takemoto K et al. | Biochemical characterization of reactive nitrogen species by eosinophil peroxidase in tyrosine nitration. | 2007 | Acta Med. Okayama | pmid:17332838 |
| Jeong NH et al. | Preoperative levels of plasma micronutrients are related to endometrial cancer risk. | 2009 | Acta Obstet Gynecol Scand | pmid:19235557 |
| Gawlik M and Czajka A | The effect of green, black and white tea on the level of alpha and gamma tocopherols in free radical-induced oxidative damage of human red blood cells. | 2007 Mar-Apr | Acta Pol Pharm | pmid:17665865 |
| Wu YM et al. | Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4. | 2016 Jul-Aug | Adv Clin Exp Med | pmid:27629837 |
| Mills K et al. | Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen. | 2014 | Allergy | pmid:24697338 |
| Morris MC et al. | Brain tocopherols related to Alzheimer's disease neuropathology in humans. | 2015 | Alzheimers Dement | pmid:24589434 |
| Gianetti J et al. | Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. | 2002 | Am. Heart J. | pmid:11868053 |
| Clarke MW et al. | Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. | 2006 | Am. J. Clin. Nutr. | pmid:16400056 |
| Morris MC et al. | Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. | 2005 | Am. J. Clin. Nutr. | pmid:15699242 |
| Jiang Q et al. | gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. | 2001 | Am. J. Clin. Nutr. | pmid:11722951 |
| Kabat GC et al. | Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. | 2009 | Am. J. Clin. Nutr. | pmid:19474140 |
| Scholl TO et al. | Vitamin E: maternal concentrations are associated with fetal growth. | 2006 | Am. J. Clin. Nutr. | pmid:17158428 |
| Ford ES et al. | Distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in the US population. | 2006 | Am. J. Clin. Nutr. | pmid:16895886 |
| Stephensen CB et al. | Vitamins C and E in adolescents and young adults with HIV infection. | 2006 | Am. J. Clin. Nutr. | pmid:16600941 |
| Devaraj S and Traber MG | Gamma-tocopherol, the new vitamin E? | 2003 | Am. J. Clin. Nutr. | pmid:12600839 |
| Liu M et al. | Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. | 2003 | Am. J. Clin. Nutr. | pmid:12600864 |
| Frank J et al. | Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. | 2008 | Am. J. Clin. Nutr. | pmid:18541561 |
| Key TJ et al. | Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. | 2007 | Am. J. Clin. Nutr. | pmid:17823432 |
| Reboul E et al. | ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice. | 2009 | Am. J. Clin. Nutr. | pmid:19056557 |
| Stone WL et al. | Infants discriminate between natural and synthetic vitamin E. | 2003 | Am. J. Clin. Nutr. | pmid:12663289 |
| Allen NE et al. | Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). | 2008 | Am. J. Clin. Nutr. | pmid:19064517 |
| Shamim AA et al. | First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh. | 2015 | Am. J. Clin. Nutr. | pmid:25646326 |
| Murtaugh MA et al. | Antioxidants, carotenoids, and risk of rectal cancer. | 2004 | Am. J. Epidemiol. | pmid:14693657 |
| Block G et al. | Which plasma antioxidants are most related to fruit and vegetable consumption? | 2001 | Am. J. Epidemiol. | pmid:11744516 |
| Schisterman EF et al. | Influence of endogenous reproductive hormones on F2-isoprostane levels in premenopausal women: the BioCycle Study. | 2010 | Am. J. Epidemiol. | pmid:20679069 |
| Huang HY et al. | Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. | 2003 | Am. J. Epidemiol. | pmid:12578804 |
| Hemilä H and Kaprio J | Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C. | 2009 | Am. J. Epidemiol. | pmid:19218294 |
| Jordan JM et al. | A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. | 2004 | Am. J. Epidemiol. | pmid:15128609 |
| Yadav D et al. | Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. | 2002 | Am. J. Gastroenterol. | pmid:12385452 |
| Palan PR et al. | Effects of menstrual cycle and oral contraceptive use on serum levels of lipid-soluble antioxidants. | 2006 | Am. J. Obstet. Gynecol. | pmid:16647895 |
| Chen J and Mehta JL | Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16714359 |
| Abdala-Valencia H et al. | γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26801566 |
| Torricelli P et al. | γ-Tocopherol inhibits human prostate cancer cell proliferation by up-regulation of transglutaminase 2 and down-regulation of cyclins. | 2013 | Amino Acids | pmid:22460364 |
| Meusinger R | Solution to spectroscopy challenge 8. | 2005 | Anal Bioanal Chem | pmid:15742181 |
| Mourvaki E et al. | Distribution of alpha-, gamma (+beta)- and delta-tocopherol in the seminal plasma, spermatozoa and seminal vesicles of rabbit. | 2008 | Andrologia | pmid:18811917 |
| Cavalca V et al. | Anesthetic propofol enhances plasma gamma-tocopherol levels in patients undergoing cardiac surgery. | 2008 | Anesthesiology | pmid:18497598 |
| Fawzi WW et al. | Calibration of a semi-quantitative food frequency questionnaire in early pregnancy. | 2004 | Ann Epidemiol | pmid:15519898 |
| White E et al. | Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative. | 2001 | Ann Epidemiol | pmid:11164130 |
| Summaries for patients. High vitamin E intake among U.S. adults. | 2005 | Ann. Intern. Med. | pmid:16027448 | |
| Ford ES et al. | Brief communication: The prevalence of high intake of vitamin E from the use of supplements among U.S. adults. | 2005 | Ann. Intern. Med. | pmid:16027453 |
| Vasankari T et al. | Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. | 2004 | Ann. Med. | pmid:15768833 |
| Parker RS et al. | Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753130 |
| Brigelius-Flohé R et al. | The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753132 |
| Stone WL et al. | Tocopherols and the treatment of colon cancer. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753148 |
| Eichhorn JC et al. | Alpha- and gamma-tocopherol plasma and urinary biokinetics following alpha-tocopherol supplementation. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753164 |
| Ulus AT et al. | Oxidative stress and changes in alpha- and gamma-tocopherol levels during coronary artery bypass grafting. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753168 |
| Frank J et al. | Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753171 |
| Sundl I et al. | The decrease in gamma-tocopherol in plasma and lipoprotein fractions levels off within two days of vitamin E supplementation. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753174 |
| Jiang Q et al. | Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753180 |
| Granado F et al. | Carotenoid depletion in serum of young type-1 diabetics fed low-carotenoid diets. | 2004 | Ann. Nutr. Metab. | pmid:15331884 |
| Ibrahim WH et al. | Effect of Ramadan fasting on markers of oxidative stress and serum biochemical markers of cellular damage in healthy subjects. | 2008 | Ann. Nutr. Metab. | pmid:19011280 |
| Wagner KH et al. | Gamma-tocopherol--an underestimated vitamin? | 2004 | Ann. Nutr. Metab. | pmid:15256801 |
| Tomasch R et al. | Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. | 2001 | Ann. Nutr. Metab. | pmid:11423702 |
| Shin MJ et al. | Relationship between insulin resistance and lipid peroxidation and antioxidant vitamins in hypercholesterolemic patients. | 2006 | Ann. Nutr. Metab. | pmid:16373994 |
| Daza A et al. | Feeding level in the period previous to the late fattening phase influences fat composition at slaughter in free-ranged Iberian pigs. | 2005 | Arch Anim Nutr | pmid:16320811 |
| Daza A et al. | Effect of age at the beginning of the free-range fattening period on growth and carcass and fat quality in Iberian pigs. | 2006 | Arch Anim Nutr | pmid:16921928 |
| López G and Galván M | [Relation of total cholesterol in serum tocopherols, probabilistic study in Mexican children]. | 2011 | Arch Latinoam Nutr | pmid:22308938 |
| Al-Bazi MM et al. | Reduced coenzyme Q(10) in female smokers and its association with lipid profile in a young healthy adult population. | 2011 | Arch Med Sci | pmid:22328876 |
| Galli F et al. | The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. | 2004 | Arch. Biochem. Biophys. | pmid:14871472 |
| Zingg JM et al. | In vivo regulation of gene transcription by alpha- and gamma-tocopherol in murine T lymphocytes. | 2013 | Arch. Biochem. Biophys. | pmid:23993952 |
| Klein A et al. | Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient mice. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16825594 |
| Singh I et al. | Effects of gamma-tocopherol supplementation on thrombotic risk factors. | 2007 | Asia Pac J Clin Nutr | pmid:17704022 |
| Werba JP et al. | A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels. | 2007 | Atherosclerosis | pmid:16860808 |
| Murr C et al. | Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease. | 2009 | Atherosclerosis | pmid:18556000 |
| Fan Y et al. | [Effect of different isoforms of tocopherols on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970893 |
| Samandari E et al. | The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16516856 |
| Deby-Dupont G et al. | Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15939398 |
| Grammas P et al. | Anti-inflammatory effects of tocopherol metabolites. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15184087 |
| Zbierzak AM et al. | Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. | 2010 | Biochem. J. | pmid:19843012 |
| McCary CA et al. | Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. | 2012 | Biochem. J. | pmid:21933153 |
| Morton LW et al. | Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease. | 2002 | Biochem. J. | pmid:11960550 |
| Montine TJ et al. | Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. | 2003 | Biochem. Pharmacol. | pmid:12566089 |
| Panagabko C et al. | Ligand specificity in the CRAL-TRIO protein family. | 2003 | Biochemistry | pmid:12767229 |
| Drummen GP et al. | Attenuation of lipid peroxidation by antioxidants in rat-1 fibroblasts: comparison of the lipid peroxidation reporter molecules cis-parinaric acid and C11-BODIPY(581/591) in a biological setting. | 2004 | Biochim. Biophys. Acta | pmid:15164761 |
| Kruk J and Trebst A | Plastoquinol as a singlet oxygen scavenger in photosystem II. | 2008 | Biochim. Biophys. Acta | pmid:18005659 |
| Reiter E et al. | Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells. | 2007 | Biofactors | pmid:18356579 |
| Galli F et al. | gamma-Tocopherol metabolism and its relationship with alpha-tocopherol in humans: a stable isotope supplementation study. | 2001 | Biofactors | pmid:12016327 |
| Passi S et al. | Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. | 2003 | Biofactors | pmid:14695926 |
| Palan PR et al. | Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants. | 2005 | Biofactors | pmid:16873930 |
| Hoppu U et al. | Serum alpha- and gamma-tocopherol levels in atopic mothers and their infants are correlated. | 2005 | Biol. Neonate | pmid:15731552 |
| Kuwabara Y et al. | Topical application of gamma-tocopherol derivative prevents UV-induced skin pigmentation. | 2006 | Biol. Pharm. Bull. | pmid:16755012 |
| Guseva DA et al. | [Antioxidant activity of vegetable oils with various omega-6/omega-3 fatty acids ratio]. | 2010 May-Jun | Biomed Khim | pmid:20695213 |
| Ohnmacht S et al. | Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E. | 2008 | Bioorg. Med. Chem. | pmid:18656365 |
| Abuasal BS et al. | Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies. | 2012 | Biopharm Drug Dispos | pmid:22528033 |
| Zigoneanu IG et al. | Determination of antioxidant components in rice bran oil extracted by microwave-assisted method. | 2008 | Bioresour. Technol. | pmid:17996444 |
| Shabtay A et al. | The potential of Pleurotus-treated olive mill solid waste as cattle feed. | 2009 | Bioresour. Technol. | pmid:19683915 |
| Xu Z | Comparison of extraction methods for quantifying vitamin E from animal tissues. | 2008 | Bioresour. Technol. | pmid:18550368 |
| Saito F et al. | Reaction products of gamma-tocopherol with (E)-4-oxo-2-nonenal in acidic acetonitrile. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20057122 |
| Jun HJ et al. | Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis. | 2006 | Biotechnol. Lett. | pmid:17028917 |
| Campbell SE et al. | Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. | 2003 | BMC Cancer | pmid:14521714 |
| Yang J et al. | Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin. | 2008 | BMC Cancer | pmid:19099597 |
| Campbell SE et al. | Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. | 2006 | BMC Cancer | pmid:16417629 |
| Liu X et al. | Survivin gene silencing sensitizes prostate cancer cells to selenium growth inhibition. | 2010 | BMC Cancer | pmid:20698994 |
| Tanaka Y et al. | Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation. | 2007 | BMC Chem Biol | pmid:17608946 |
| Hossain M et al. | In vitro assessment of tobacco smoke toxicity at the BBB: do antioxidant supplements have a protective role? | 2011 | BMC Neurosci | pmid:21943155 |
| GarcÃa-Moreno MJ et al. | Genetic basis of unstable expression of high gamma-tocopherol content in sunflower seeds. | 2012 | BMC Plant Biol. | pmid:22607470 |
| Puri BK et al. | A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation. | 2008 | BMC Psychiatry | pmid:18433514 |
| Hodge A et al. | Plasma carotenoids are associated with socioeconomic status in an urban Indigenous population: an observational study. | 2011 | BMC Public Health | pmid:21288365 |