Gamma-tocopherol is a lipid of Prenol Lipids (PR) class. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Adverse effects, Longterm Effects, Luteal Phase and Drug Interactions. Gamma-tocopherol often locates in Blood. The related lipids are Total cholesterol.
To understand associated biological information of gamma-tocopherol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-tocopherol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang HY and Appel LJ | Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. | 2003 | J. Nutr. | pmid:14519797 |
| Frank J et al. | Dietary (+)-catechin and BHT markedly increase alpha-tocopherol concentrations in rats by a tocopherol-omega-hydroxylase-independent mechanism. | 2003 | J. Nutr. | pmid:14519810 |
| Goodman GE et al. | The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. | 2003 | Cancer Epidemiol. Biomarkers Prev. | pmid:12814997 |
| Hak AE et al. | Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. | 2003 | Circulation | pmid:12900344 |
| Campbell SE et al. | Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. | 2003 | BMC Cancer | pmid:14521714 |
| Panagabko C et al. | Ligand specificity in the CRAL-TRIO protein family. | 2003 | Biochemistry | pmid:12767229 |
| Nelson JL et al. | Dietary modification and moderate antioxidant supplementation differentially affect serum carotenoids, antioxidant levels and markers of oxidative stress in older humans. | 2003 | J. Nutr. | pmid:14519794 |
| Hou RC et al. | Effect of sesame antioxidants on LPS-induced NO production by BV2 microglial cells. | 2003 | Neuroreport | pmid:14534426 |
| Min J et al. | [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)]. | 2003 | Wei Sheng Yan Jiu | pmid:14535097 |
| Azzi A et al. | The role of alpha-tocopherol in preventing disease: from epidemiology to molecular events. | 2003 | Mol. Aspects Med. | pmid:14585303 |
| Passi S et al. | Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. | 2003 | Biofactors | pmid:14695926 |
| Stone WL et al. | Infants discriminate between natural and synthetic vitamin E. | 2003 | Am. J. Clin. Nutr. | pmid:12663289 |
| Sattler SE et al. | Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function. | 2003 | Plant Physiol. | pmid:12913173 |
| Pal S et al. | Alpha-tocopherol modulates the low density lipoprotein receptor of human HepG2 cells. | 2003 | Nutr J | pmid:12773205 |
| Falk J et al. | Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves. | 2003 | FEBS Lett. | pmid:12681479 |
| Collakova E and DellaPenna D | Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. | 2003 | Plant Physiol. | pmid:12586887 |
| Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
| O'Sullivan AJ et al. | Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol. | 2003 May-Jun | J Appl Toxicol | pmid:12794941 |
| Soo CC et al. | Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors. | 2004 | J. Natl. Cancer Inst. | pmid:15150308 |
| Granado F et al. | Carotenoid depletion in serum of young type-1 diabetics fed low-carotenoid diets. | 2004 | Ann. Nutr. Metab. | pmid:15331884 |
| Palan PR et al. | Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy. | 2004 | Gynecol. Obstet. Invest. | pmid:14988604 |
| O'Sullivan SM et al. | Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers. | 2004 | Br. J. Nutr. | pmid:15137928 |
| Parker RS et al. | Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753130 |
| Brigelius-Flohé R et al. | The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753132 |
| Stone WL et al. | Tocopherols and the treatment of colon cancer. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753148 |
| Eichhorn JC et al. | Alpha- and gamma-tocopherol plasma and urinary biokinetics following alpha-tocopherol supplementation. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753164 |
| Ulus AT et al. | Oxidative stress and changes in alpha- and gamma-tocopherol levels during coronary artery bypass grafting. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753168 |
| Frank J et al. | Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753171 |
| Sundl I et al. | The decrease in gamma-tocopherol in plasma and lipoprotein fractions levels off within two days of vitamin E supplementation. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753174 |
| Jiang Q et al. | Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753180 |
| Vasankari T et al. | Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. | 2004 | Ann. Med. | pmid:15768833 |
| McCormick CC and Parker RS | The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait. | 2004 | J. Nutr. | pmid:15570034 |
| Drummen GP et al. | Attenuation of lipid peroxidation by antioxidants in rat-1 fibroblasts: comparison of the lipid peroxidation reporter molecules cis-parinaric acid and C11-BODIPY(581/591) in a biological setting. | 2004 | Biochim. Biophys. Acta | pmid:15164761 |
| Ishihara O et al. | Isoprostanes, prostaglandins and tocopherols in pre-eclampsia, normal pregnancy and non-pregnancy. | 2004 | Free Radic. Res. | pmid:15621708 |
| Murtaugh MA et al. | Antioxidants, carotenoids, and risk of rectal cancer. | 2004 | Am. J. Epidemiol. | pmid:14693657 |
| Ross AB et al. | Cereal alkylresorcinols elevate gamma-tocopherol levels in rats and inhibit gamma-tocopherol metabolism in vitro. | 2004 | J. Nutr. | pmid:14988438 |
| Galli F et al. | Accumulation of vitamin E metabolites in the blood of renal failure patients. | 2004 | Clin Nutr | pmid:15030960 |
| Jiang Q et al. | gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15596715 |
| Baldwin C et al. | Changes in circulating concentrations of vitamins and trace elements after cessation of nocturnal enteral tube feeding. | 2004 | Clin Nutr | pmid:15030965 |
| Jauniaux E et al. | Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15001647 |
| Fawzi WW et al. | Calibration of a semi-quantitative food frequency questionnaire in early pregnancy. | 2004 | Ann Epidemiol | pmid:15519898 |
| Uto H et al. | Gamma-tocopherol enhances sodium excretion as a natriuretic hormone precursor. | 2004 | J. Nutr. Sci. Vitaminol. | pmid:15527070 |
| Buszewski B et al. | Effect of stationary phase structure on retention and selectivity tuning in the high-throughput separation of tocopherol isomers by HPLC. | 2004 | Comb. Chem. High Throughput Screen. | pmid:15200386 |
| Galli F et al. | The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. | 2004 | Arch. Biochem. Biophys. | pmid:14871472 |
| Pfluger P et al. | Vitamin E: underestimated as an antioxidant. | 2004 | Redox Rep. | pmid:15606977 |
| Colgan HA et al. | Increased intake of fruit and vegetables and a low-fat diet, with and without low-fat plant sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism. | 2004 | J Hum Nutr Diet | pmid:15546434 |
| Ros E et al. | A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. | 2004 | Circulation | pmid:15037535 |
| O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
| Ramel A et al. | Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. | 2004 | Eur J Nutr | pmid:14991263 |
| Begum R et al. | Supplementation with n-3 and n-6 polyunsaturated fatty acids: effects on lipoxygenase activity and clinical symptoms of pruritus in hemodialysis patients. | 2004 | J Ren Nutr | pmid:15483784 |
| Donaldson MS | Nutrition and cancer: a review of the evidence for an anti-cancer diet. | 2004 | Nutr J | pmid:15496224 |
| Gimeno A et al. | Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C. | 2004 | FEBS Lett. | pmid:15225641 |
| Cauza E et al. | Effects of LDL-immunoapheresis on plasma concentrations of vitamin E and carotenoids in patients with familial hypercholesterolemia. | 2004 | J Clin Apher | pmid:15597350 |
| Seybold C et al. | Changes in contents of carotenoids and vitamin E during tomato processing. | 2004 | J. Agric. Food Chem. | pmid:15537310 |
| Ferroni F et al. | Phenolic antioxidants and the protection of low density lipoprotein from peroxynitrite-mediated oxidations at physiologic CO2. | 2004 | J. Agric. Food Chem. | pmid:15137827 |
| Vatassery GT et al. | Alpha and gamma tocopherols in cerebrospinal fluid and serum from older, male, human subjects. | 2004 | J Am Coll Nutr | pmid:15190048 |
| Alvarez-Ayuso L et al. | Antioxidant effect of gamma-tocopherol supplied by propofol preparations (Diprivan) during ischemia-reperfusion in experimental lung transplantation. | 2004 | Transpl. Int. | pmid:14574450 |
| Lykkesfeldt J et al. | Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles. | 2004 | Br. J. Nutr. | pmid:15333149 |
| Friedrich MJ | To "E" or not to "E," vitamin E's role in health and disease is the question. | 2004 | JAMA | pmid:15304447 |
| Wagner KH et al. | Gamma-tocopherol--an underestimated vitamin? | 2004 | Ann. Nutr. Metab. | pmid:15256801 |
| Sobczak A et al. | The effects of tobacco smoke on plasma alpha- and gamma-tocopherol levels in passive and active cigarette smokers. | 2004 | Toxicol. Lett. | pmid:15261987 |
| Mawatari S et al. | Absence of correlation between glycated hemoglobin and lipid composition of erythrocyte membrane in type 2 diabetic patients. | 2004 | Metab. Clin. Exp. | pmid:14681853 |
| I read recently that foods high in vitamin E may be more beneficial than supplements containing vitamin E. Please explain. | 2004 | Mayo Clin Health Lett | pmid:15237479 | |
| Bates CJ et al. | Gamma-tocopherol as a possible marker for nutrition-related risk: results from four National Diet and Nutrition Surveys in Britain. | 2004 | Br. J. Nutr. | pmid:15230997 |
| Felton EE and Kerley MS | Performance and carcass quality of steers fed different sources of dietary fat. | 2004 | J. Anim. Sci. | pmid:15217008 |
| Nogala-Kalucka M et al. | Tocopherol composition of deodorization distillates and their antioxidative activity. | 2004 | Nahrung | pmid:15053348 |
| Nagata Y et al. | Products of the reaction between alpha- or gamma-tocopherol and nitrogen oxides analyzed by high-performance liquid chromatography with UV-visible and atmospheric pressure chemical ionization mass spectrometric detection. | 2004 | J Chromatogr A | pmid:15146919 |
| Jordan JM et al. | A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. | 2004 | Am. J. Epidemiol. | pmid:15128609 |
| Mahabir S et al. | Randomized, placebo-controlled pilot trial of the effects of alpha-tocopherol supplementation on levels of autoantibodies against 5-hydroxymethyl-2-deoxyuridine in melanoma patients. | 2004 | Melanoma Res. | pmid:15091194 |
| Hensley K et al. | New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. | 2004 | Free Radic. Biol. Med. | pmid:14732286 |
| Botti H et al. | Peroxynitrite-mediated alpha-tocopherol oxidation in low-density lipoprotein: a mechanistic approach. | 2004 | Free Radic. Biol. Med. | pmid:14744627 |
| Yuan JM et al. | Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533906 |
| Allen NE et al. | A case--control study of selenium in nails and prostate cancer risk in British men. | 2004 | Br. J. Cancer | pmid:15054461 |
| Sánchez-Moreno C et al. | Dietary fat type affects vitamins C and E and biomarkers of oxidative status in peripheral and brain tissues of golden Syrian hamsters. | 2004 | J. Nutr. | pmid:14988463 |
| Fan Y et al. | [Effect of different isoforms of tocopherols on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970893 |
| Lee DH et al. | Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. | 2004 | Clin. Chem. | pmid:14726472 |
| Grammas P et al. | Anti-inflammatory effects of tocopherol metabolites. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15184087 |
| Aydemir O et al. | Protective effects of vitamin E forms (alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina. | 2004 Oct-Dec | Int Ophthalmol | pmid:16532291 |
| Weinstein SJ et al. | Serum alpha-tocopherol and gamma-tocopherol in relation to prostate cancer risk in a prospective study. | 2005 | J. Natl. Cancer Inst. | pmid:15741576 |
| Meusinger R | Solution to spectroscopy challenge 8. | 2005 | Anal Bioanal Chem | pmid:15742181 |
| Olmedilla-Alonso B et al. | Carotenoids, retinol and tocopherols in blood: comparability between serum and plasma (Li-heparin) values. | 2005 | Clin. Biochem. | pmid:15820775 |
| Ford ES et al. | Associations between concentrations of alpha- and gamma-tocopherol and concentrations of glucose, glycosylated haemoglobin, insulin and C-peptide among US adults. | 2005 | Br. J. Nutr. | pmid:15788118 |
| Jambazian PR et al. | Almonds in the diet simultaneously improve plasma alpha-tocopherol concentrations and reduce plasma lipids. | 2005 | J Am Diet Assoc | pmid:15746835 |
| Leonard SW et al. | Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production. | 2005 | Free Radic. Biol. Med. | pmid:15749381 |
| Cho EA et al. | Expression of gamma-tocopherol methyltransferase transgene improves tocopherol composition in lettuce (Latuca sativa L.). | 2005 | Mol. Cells | pmid:15750335 |
| Summaries for patients. High vitamin E intake among U.S. adults. | 2005 | Ann. Intern. Med. | pmid:16027448 | |
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| Kluth D et al. | Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice. | 2005 | Free Radic. Biol. Med. | pmid:15649653 |
| Morris MC et al. | Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. | 2005 | Am. J. Clin. Nutr. | pmid:15699242 |
| Krishnan K et al. | More optimal forms of vitamin E. | 2005 | J Am Diet Assoc | pmid:15668675 |
| Hoppu U et al. | Serum alpha- and gamma-tocopherol levels in atopic mothers and their infants are correlated. | 2005 | Biol. Neonate | pmid:15731552 |
| Li C et al. | [Effects of packaging on the stability of vitamin E in peach kernels stored at high temperature]. | 2005 | Zhong Yao Cai | pmid:15981891 |
| Sachdeva R et al. | Tocopherol metabolism using thermochemolysis: chemical and biological properties of gamma-tocopherol, gamma-carboxyethyl-hydroxychroman, and their quinones. | 2005 | Chem. Res. Toxicol. | pmid:15962937 |
| Helmersson J et al. | Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15763433 |
| Johansen JS et al. | Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. | 2005 | Cardiovasc Diabetol | pmid:15862133 |
| Ostenfeld MS et al. | Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. | 2005 | Cancer Res. | pmid:16204071 |
| Nouraie M et al. | Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:16172214 |
| Kristal AR et al. | Centralized blood processing for the selenium and vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte viability. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15767358 |
| Traber MG et al. | Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. | 2005 | Free Radic. Biol. Med. | pmid:15721988 |
| Palan PR et al. | Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants. | 2005 | Biofactors | pmid:16873930 |