Gamma-tocopherol is a lipid of Prenol Lipids (PR) class. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Adverse effects, Longterm Effects, Luteal Phase and Drug Interactions. Gamma-tocopherol often locates in Blood. The related lipids are Total cholesterol.
To understand associated biological information of gamma-tocopherol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-tocopherol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abdollahzadeh Sh et al. | Antibacterial and antifungal activities of punica granatum peel extracts against oral pathogens. | 2011 | J Dent (Tehran) | pmid:21998800 |
| Chen T et al. | Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. | 2010 | J Diet Suppl | pmid:22435611 |
| Nagao M et al. | Relation of serum α- and γ-tocopherol levels to cardiovascular disease-related mortality among Japanese men and women. | 2012 | J Epidemiol | pmid:22672959 |
| Rehkopf DH et al. | Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the USA (NHANES). | 2010 | J Epidemiol Community Health | pmid:19822554 |
| Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
| Colgan HA et al. | Increased intake of fruit and vegetables and a low-fat diet, with and without low-fat plant sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism. | 2004 | J Hum Nutr Diet | pmid:15546434 |
| Geiser M et al. | Effects of ex vivo γ-tocopherol on airway macrophage function in healthy and mild allergic asthmatics. | 2013 | J Innate Immun | pmid:23689260 |
| Alipour M et al. | Acute toxicity study of liposomal antioxidant formulations containing N-acetylcysteine, α-tocopherol, and γ-tocopherol in rats. | 2012 | J Liposome Res | pmid:22401703 |
| Bhutia Y et al. | Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics. | 2011 | J Nat Sci Biol Med | pmid:22470243 |
| Aoi W et al. | Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function. | 2011 | J Nutr Metab | pmid:21773023 |
| El-Mallah MH and El-Shami SM | Investigation of liquid wax components of Egyptian jojoba seeds. | 2009 | J Oleo Sci | pmid:19844068 |
| Banerji R et al. | Oil and fatty acid diversity in genetically variable clones of Moringa oleifera from India. | 2009 | J Oleo Sci | pmid:19075502 |
| Fanali S et al. | Separation of delta-, gamma- and alpha-tocopherols by CEC. | 2002 | J Pharm Biomed Anal | pmid:12110381 |
| Siluk D et al. | A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma. | 2007 | J Pharm Biomed Anal | pmid:17499473 |
| Begum R et al. | Supplementation with n-3 and n-6 polyunsaturated fatty acids: effects on lipoxygenase activity and clinical symptoms of pruritus in hemodialysis patients. | 2004 | J Ren Nutr | pmid:15483784 |
| Himmelfarb J et al. | Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. | 2007 | J Ren Nutr | pmid:17720098 |
| Kashinakunti SV et al. | Comparative study of serum MDA and vitamin C levels in non-smokers, chronic smokers and chronic smokers with acute myocardial infarction in men. | 2011 | J Res Med Sci | pmid:22279473 |
| Krcmová L et al. | HPLC method for simultaneous determination of retinoids and tocopherols in human serum for monitoring of anticancer therapy. | 2009 | J Sep Sci | pmid:19606446 |
| Paromov V et al. | Protective effect of liposome-encapsulated glutathione in a human epidermal model exposed to a mustard gas analog. | 2011 | J Toxicol | pmid:21776256 |
| Li L et al. | Fatty acid profiles, tocopherol contents, and antioxidant activities of heartnut (Juglans ailanthifolia Var. cordiformis) and Persian walnut (Juglans regia L.). | 2007 | J. Agric. Food Chem. | pmid:17253708 |
| Rozzi NL et al. | Supercritical fluid extraction of lycopene from tomato processing byproducts. | 2002 | J. Agric. Food Chem. | pmid:11958635 |
| Cheng WY et al. | Isolation and identification of novel estrogenic compounds in yam tuber (Dioscorea alata Cv. Tainung No. 2). | 2007 | J. Agric. Food Chem. | pmid:17685543 |
| Jham GN et al. | Gamma-tocopherol as a marker of Brazilian coffee (Coffea arabica L.) adulteration by corn. | 2007 | J. Agric. Food Chem. | pmid:17602658 |
| Let MB et al. | Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently. | 2007 | J. Agric. Food Chem. | pmid:17319681 |
| Tlili N et al. | Carotenoid and tocopherol composition of leaves, buds, and flowers of Capparis spinosa grown wild in Tunisia. | 2009 | J. Agric. Food Chem. | pmid:19473002 |
| Goffman FD and Böhme T | Relationship between fatty acid profile and vitamin E content in maize hybrids (Zea mays L.). | 2001 | J. Agric. Food Chem. | pmid:11600056 |
| Bandelier J et al. | Original study of the biochemical and oil composition of the Cambodia nut Irvingia malayana. | 2002 | J. Agric. Food Chem. | pmid:11879024 |
| Carbonaro M et al. | Modulation of antioxidant compounds in organic vs conventional fruit (peach, Prunus persica L., and pear, Pyrus communis L.). | 2002 | J. Agric. Food Chem. | pmid:12207491 |
| Xu Z et al. | Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. | 2001 | J. Agric. Food Chem. | pmid:11308370 |
| Britz SJ and Kremer DF | Warm temperatures or drought during seed maturation increase free alpha-tocopherol in seeds of soybean (Glycine max [L.] Merr.). | 2002 | J. Agric. Food Chem. | pmid:12358480 |
| Goffman FD and Galletti S | Gamma-linolenic acid and tocopherol contents in the seed oil of 47 accessions from several Ribes species. | 2001 | J. Agric. Food Chem. | pmid:11170598 |
| Turan S et al. | Fatty acid, triacylglycerol, phytosterol, and tocopherol variations in kernel oil of Malatya apricots from Turkey. | 2007 | J. Agric. Food Chem. | pmid:18038980 |
| Seybold C et al. | Changes in contents of carotenoids and vitamin E during tomato processing. | 2004 | J. Agric. Food Chem. | pmid:15537310 |
| Moreau RA and Hicks KB | Reinvestigation of the effect of heat pretreatment of corn fiber and corn germ on the levels of extractable tocopherols and tocotrienols. | 2006 | J. Agric. Food Chem. | pmid:17032015 |
| Frank J et al. | Effects of dietary anthocyanins on tocopherols and lipids in rats. | 2002 | J. Agric. Food Chem. | pmid:12452636 |
| Gentile C et al. | Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components. | 2007 | J. Agric. Food Chem. | pmid:17263455 |
| Gómez-Coronado DJ and Barbas C | Optimized and validated HPLC method for alpha- and gamma-tocopherol measurement in Laurus nobilis leaves. New data on tocopherol content. | 2003 | J. Agric. Food Chem. | pmid:12926858 |
| Ferroni F et al. | Phenolic antioxidants and the protection of low density lipoprotein from peroxynitrite-mediated oxidations at physiologic CO2. | 2004 | J. Agric. Food Chem. | pmid:15137827 |
| Isnardy B et al. | Effects of alpha-, gamma-, and delta-tocopherols on the autoxidation of purified rapeseed oil triacylglycerols in a system containing low oxygen. | 2003 | J. Agric. Food Chem. | pmid:14664544 |
| Warner K et al. | Enhancing quality and oxidative stability of aged fried food with gamma-tocopherol. | 2003 | J. Agric. Food Chem. | pmid:12537432 |
| Cabrini L et al. | Antioxidants and total peroxyl radical-trapping ability of olive and seed oils. | 2001 | J. Agric. Food Chem. | pmid:11743803 |
| Polidori MC et al. | High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. | 2009 | J. Alzheimers Dis. | pmid:19542607 |
| Felton EE and Kerley MS | Performance and carcass quality of steers fed different sources of dietary fat. | 2004 | J. Anim. Sci. | pmid:15217008 |
| Zwart SR et al. | Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans. | 2009 | J. Appl. Physiol. | pmid:19074571 |
| Fischer CP et al. | Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans. | 2006 | J. Appl. Physiol. | pmid:16384840 |
| Browne RW et al. | Follicular fluid high density lipoprotein-associated micronutrient levels are associated with embryo fragmentation during IVF. | 2009 Nov-Dec | J. Assist. Reprod. Genet. | pmid:19921421 |
| Mukherjee S et al. | Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes. | J. Biochem. Mol. Toxicol. | pmid:19367648 | |
| Ahn KS et al. | Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | 2007 | J. Biol. Chem. | pmid:17114179 |
| Reboul E et al. | Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte. | 2006 | J. Biol. Chem. | pmid:16380385 |
| d'Harlingue A and Camara B | Plastid enzymes of terpenoid biosynthesis. Purification and characterization of gamma-tocopherol methyltransferase from Capsicum chromoplasts. | 1985 | J. Biol. Chem. | pmid:4066669 |
| Royer MC et al. | 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. | 2009 | J. Biol. Chem. | pmid:19351882 |
| Sontag TJ and Parker RS | Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. | 2002 | J. Biol. Chem. | pmid:11997390 |
| Kannappan R et al. | γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. | 2010 | J. Biol. Chem. | pmid:20720018 |
| Kuo DC et al. | Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters. | 2009 | J. Biomed. Sci. | pmid:19272178 |
| Hamidi MS et al. | Effects of vitamin E on bone turnover markers among US postmenopausal women. | 2012 | J. Bone Miner. Res. | pmid:22308007 |
| Clarke MW et al. | Vitamin E supplementation and hepatic drug metabolism in humans. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19755916 |
| Paliakov EM et al. | Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19041283 |
| Milatovic D et al. | Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16260380 |
| Thibeault D et al. | Isocratic rapid liquid chromatographic method for simultaneous determination of carotenoids, retinol, and tocopherols in human serum. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19297254 |
| Jauniaux E et al. | Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac. | 2004 | J. Clin. Endocrinol. Metab. | pmid:15001647 |
| Linden GJ et al. | Antioxidants and periodontitis in 60-70-year-old men. | 2009 | J. Clin. Periodontol. | pmid:19703237 |
| Papas KA et al. | A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosis. | 2008 | J. Cyst. Fibros. | pmid:17569601 |
| Abreu ME and Munné-Bosch S | Salicylic acid deficiency in NahG transgenic lines and sid2 mutants increases seed yield in the annual plant Arabidopsis thaliana. | 2009 | J. Exp. Bot. | pmid:19188277 |
| Hwang ES et al. | Effects of heat treatment on the carotenoid and tocopherol composition of tomato. | 2012 | J. Food Sci. | pmid:22950575 |
| Mao Y et al. | Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. | 2017 | J. Food Sci. | pmid:28135396 |
| Mohamed R et al. | Roselle (Hibiscus sabdariffa) seed oil is a rich source of gamma-tocopherol. | 2007 | J. Food Sci. | pmid:17995816 |
| Wang S et al. | Temperature dependence of autoxidation of perilla oil and tocopherol degradation. | 2010 | J. Food Sci. | pmid:20722903 |
| Yang D et al. | Antioxidative activities of Ginkgo biloba extract on oil/water emulsion system prepared from an enzymatically modified lipid containing alpha-linolenic acid. | 2013 | J. Food Sci. | pmid:23278764 |
| Kim JS et al. | Phytochemicals and antioxidant activity of fruits and leaves of paprika (Capsicum Annuum L., var. special) cultivated in Korea. | 2011 | J. Food Sci. | pmid:21535734 |
| Veronezi CM and Jorge N | Bioactive compounds in lipid fractions of pumpkin (Cucurbita sp) seeds for use in food. | 2012 | J. Food Sci. | pmid:22671521 |
| Vujasinović V et al. | Optimization of hull-less pumpkin seed roasting conditions using response surface methodology. | 2012 | J. Food Sci. | pmid:23163936 |
| D'Adamo CR et al. | Serum vitamin E concentrations and recovery of physical function during the year after hip fracture. | 2011 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:21486921 |
| Dodge HH et al. | Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study. | 2010 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:20643702 |
| Ward NC et al. | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. | 2007 | J. Hypertens. | pmid:17143195 |
| McCary CA et al. | Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of α-tocopherol and γ-tocopherol's effects. | 2011 | J. Immunol. | pmid:21317387 |
| Wang Y et al. | Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of Sphingolipids. | 2015 | J. Immunol. | pmid:26002975 |
| Mangialasche F et al. | Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol. | 2013 | J. Intern. Med. | pmid:23343471 |
| Vessby J et al. | Oxidative stress and antioxidant status in type 1 diabetes mellitus. | 2002 | J. Intern. Med. | pmid:11851867 |
| Yoshida E et al. | Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. | 2006 | J. Invest. Dermatol. | pmid:16543897 |
| Konger RL | A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic gamma-tocopherol derivative compared with alpha-tocopherol. | 2006 | J. Invest. Dermatol. | pmid:16778813 |
| Lehner F et al. | Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. | 2006 | J. Lipid Res. | pmid:16299352 |
| Christen S et al. | Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. | 2002 | J. Lipid Res. | pmid:12401897 |
| Takata J et al. | Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC. | 2002 | J. Lipid Res. | pmid:12454283 |
| Schwenke DC et al. | In vitro lipid peroxidation of LDL from postmenopausal cynomolgus macaques treated with female hormones. | 1999 | J. Lipid Res. | pmid:9925652 |
| Sundl I et al. | Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene - 1131T>C variant and associations with plasma lipids and lipid peroxidation. | 2007 | J. Lipid Res. | pmid:17693622 |
| Jiang Q et al. | Identification and quantitation of novel vitamin E metabolites, sulfated long-chain carboxychromanols, in human A549 cells and in rats. | 2007 | J. Lipid Res. | pmid:17299205 |
| Leonard SW et al. | Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration. | 2005 | J. Lipid Res. | pmid:15722564 |
| Schurgers LJ et al. | Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men. | 2002 | J. Lipid Res. | pmid:12032162 |
| Devaraj S et al. | Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages. | 2001 | J. Lipid Res. | pmid:11290823 |
| Saito H et al. | Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. | 2003 | J. Lipid Res. | pmid:12730299 |
| Yan R et al. | Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors. | 2015 | J. Med. Chem. | pmid:25689347 |
| Takahashi K et al. | gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats. | 2006 | J. Mol. Cell. Cardiol. | pmid:16876819 |
| Soo CC et al. | Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors. | 2004 | J. Natl. Cancer Inst. | pmid:15150308 |
| Weinstein SJ et al. | Serum alpha-tocopherol and gamma-tocopherol in relation to prostate cancer risk in a prospective study. | 2005 | J. Natl. Cancer Inst. | pmid:15741576 |
| Milatovic D et al. | Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. | 2003 | J. Neurochem. | pmid:14713307 |
| Sacha B et al. | Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells. | 2008 | J. Neurosci. Res. | pmid:18709655 |
| Cheng TY et al. | Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers. | 2011 | J. Nutr. | pmid:21795425 |
| Mumford SL et al. | Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women. | 2016 | J. Nutr. | pmid:26581679 |
| Sánchez-Moreno C et al. | Dietary fat type affects vitamins C and E and biomarkers of oxidative status in peripheral and brain tissues of golden Syrian hamsters. | 2004 | J. Nutr. | pmid:14988463 |
| West KP et al. | A Plasma α-Tocopherome Can Be Identified from Proteins Associated with Vitamin E Status in School-Aged Children of Nepal. | 2015 | J. Nutr. | pmid:26446483 |