phylloquinone

Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phylloquinone?

phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with phylloquinone

MeSH term MeSH ID Detail
Vitamin K Deficiency D014813 5 associated lipids
Thromboembolism D013923 6 associated lipids
Exanthema D005076 11 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with phylloquinone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phylloquinone?

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What functions are associated with phylloquinone?


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What lipids are associated with phylloquinone?

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What genes are associated with phylloquinone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phylloquinone?

Knock-out

Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).

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NCBI Entrez Crosslinks

All references with phylloquinone

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Authors Title Published Journal PubMed Link
GUTTAS CG et al. Studies on the anticoagulant phenylindanedione. I. The effect of emulsified vitamin K1 on phenylindanedione-induced hypoprothrombinemia. 1953 Blood pmid:13032197
CHALMERS JN et al. Antagonistic effect of oral vitamin K1 on the action of ethyl biscoumacetate and phenylindanedione. 1954 Br Med J pmid:13199354
DAWSON P Effect of intravenous vitamin K1 on the action of phenindione. 1955 Br Med J pmid:13269887
ENGLISH A et al. Vitamin K1 in the control of phenylindanedione-induced anticoagulant therapy. 1955 Can Med Assoc J pmid:13231011
BEAMISH RE and STORRIE VM Severe haemolytic reaction following the intravenous administration of emulsified vitamin K (mephyton). 1956 Can Med Assoc J pmid:13284670
BEYER RE The effect of ultraviolet light on mitochondria. II. Restoration of oxidative phosphorylation with vitamin K1 after near-ultraviolet treatment. 1959 J. Biol. Chem. pmid:13641285
ANDERSON WW and DALLAM RD The effect of vitamin K1 on oxidative phosphorylation of rat liver mitochondria irradiated with ultraviolet light. 1959 J. Biol. Chem. pmid:13630920
MUSHETT CW et al. Efficacy of water-soluble derivatives of vitamin K1 in counteracting drug-induced hypoprothrombinemia. 1959 Blood pmid:13607577
LOWENTHAL J and TAYLOR JD A method for measuring the activity of compounds with an activity like vitamin K against indirect anticoagulants in rats. 1959 Br J Pharmacol Chemother pmid:13651573
WOSILAIT WD The reduction of vitamin K1 by an enzyme from dog liver. 1960 J. Biol. Chem. pmid:13846011