MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kutsop JJ | Update on vitamin K1 content of enteral products. | 1984 | Am J Hosp Pharm | pmid:6437219 |
Babcock J et al. | Rodenticide-induced coagulopathy in a young child. A case of Munchausen syndrome by proxy. | 1993 | Am J Pediatr Hematol Oncol | pmid:8447555 |
Glatstein M et al. | Emergency use of intravenous phytonadione (vitamin K1) for treatment of severe bleeding in a child with chronic cholestasis. | 2013 Nov-Dec | Am J Ther | pmid:21642829 |
Nee R et al. | Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation. | 1999 | Am. J. Cardiol. | pmid:10073841 |
Dashti HS et al. | Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. | 2014 | Am. J. Clin. Nutr. | pmid:25411281 |
Mummah-Schendel LL and Suttie JW | Serum phylloquinone concentrations in a normal adult population. | 1986 | Am. J. Clin. Nutr. | pmid:3766455 |
Bach AU et al. | Assessment of vitamin K status in human subjects administered "minidose" warfarin. | 1996 | Am. J. Clin. Nutr. | pmid:8942414 |
Booth SL et al. | Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adults. | 1999 | Am. J. Clin. Nutr. | pmid:10479199 |
Nimptsch K et al. | Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). | 2010 | Am. J. Clin. Nutr. | pmid:20335553 |
Troy LM et al. | Dihydrophylloquinone intake is associated with low bone mineral density in men and women. | 2007 | Am. J. Clin. Nutr. | pmid:17684225 |