MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stork CM et al. | Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy. | 2011 | Am J Health Syst Pharm | pmid:21593229 |
Schimpf KJ et al. | Determination of trans vitamin K1 in infant and medical nutritional products using AOAC Method 999.15 with modified preparation and extraction procedures and C30 bonded phase chromatography: single-laboratory validation. | 2010 Mar-Apr | J AOAC Int | pmid:20480913 |
Chen XH et al. | [Analysis of thirteen cases with secondary coagulation disorder caused by raticide exposure]. | 2010 | Zhonghua Er Ke Za Zhi | pmid:21055312 |
Kuwabara A et al. | Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. | 2010 | Asia Pac J Clin Nutr | pmid:20199987 |
Ducros V et al. | Quantitative determination of plasma vitamin K1 by high-performance liquid chromatography coupled to isotope dilution tandem mass spectrometry. | 2010 | Anal. Biochem. | pmid:20175981 |
Crivello NA et al. | Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides. | 2010 | J. Nutr. Biochem. | pmid:20092997 |
Giuliano V et al. | Small intestinal bacterial overgrowth and warfarin dose requirement variability. | 2010 | Thromb. Res. | pmid:20051286 |
Tanaka S et al. | Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. | 2010 | Clin. Exp. Immunol. | pmid:20030669 |
Novotny JA et al. | Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale. | 2010 | Br. J. Nutr. | pmid:20420753 |
Beulens JW et al. | Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. | 2010 | Diabetes Care | pmid:20424220 |