MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Duggan P et al. | Vitamin K status in patients with Crohn's disease and relationship to bone turnover. | 2004 | Am. J. Gastroenterol. | pmid:15555000 |
Conly JM et al. | The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. | 1994 | Am. J. Gastroenterol. | pmid:8198105 |
Pauli RM et al. | Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. | 1987 | Am. J. Hum. Genet. | pmid:3499071 |
Essalihi R et al. | A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. | 2003 | Am. J. Hypertens. | pmid:12559675 |
Pilkey RM et al. | Subclinical vitamin K deficiency in hemodialysis patients. | 2007 | Am. J. Kidney Dis. | pmid:17336705 |
O'Seaghdha CM et al. | Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. | 2012 | Am. J. Nephrol. | pmid:22722822 |
Eronick J et al. | Effects of sodium warfarin administered during pregnancy in mice. | 1974 | Am. J. Obstet. Gynecol. | pmid:4815864 |
Hiraike H et al. | Distribution of K vitamins (phylloquinone and menaquinones) in human placenta and maternal and umbilical cord plasma. | 1988 | Am. J. Obstet. Gynecol. | pmid:3348316 |
Sann L et al. | Serum vitamin K1 concentration and vitamin K-dependent clotting factor activity in maternal and fetal cord blood. | 1985 | Am. J. Obstet. Gynecol. | pmid:4073142 |
Hollander D and Rim E | Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. | 1978 | Am. J. Physiol. | pmid:623249 |