MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Clarke P et al. | Total and Differential Phylloquinone (Vitamin K1) Intakes of Preterm Infants from All Sources during the Neonatal Period. | 2015 | Nutrients | pmid:26426042 |
Chouet J et al. | Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. | 2015 | Nutrients | pmid:26274973 |
Response of human beings to vitamin K 1. | 1969 | Nutr. Rev. | pmid:4901122 | |
Cashman KD and O'Connor E | Does high vitamin K1 intake protect against bone loss in later life? | 2008 | Nutr. Rev. | pmid:18752477 |
Shea MK and Booth SL | Update on the role of vitamin K in skeletal health. | 2008 | Nutr. Rev. | pmid:18826451 |
Vitamin K hydroperoxide: an intermediate in gamma-glutamate carboxylation? | 1984 | Nutr. Rev. | pmid:6384837 | |
Conversion of vitamin K epoxide to hydroxyvitamin K by liver microsomes from warfarin-resistant rats. | 1983 | Nutr. Rev. | pmid:6355923 | |
Megavitamin E supplementation and vitamin K-dependent carboxylation. | 1983 | Nutr. Rev. | pmid:6358960 | |
Interaction between vitamin K1 and fat absorption. | 1976 | Nutr. Rev. | pmid:794771 | |
Lamb JJ et al. | Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₠produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. | 2011 | Nutr Res | pmid:21636012 |