MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hata Y | [Vitamin K in obstetrics--effects of vitamin K1 on threatened abortion and premature labor]. | 1967 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:5627227 |
Vetter W et al. | [Gas chromatography and mass spectrometry investigations of phytylubiquinone Vitamin K1, and Vitamin K2]. | 1967 | Helv. Chim. Acta | pmid:5590992 |
Griffiths WT et al. | Nature, intracellular distribution and formation of terpenoid quinones in maize and barley shoots. | 1967 | Biochem. J. | pmid:6032988 |
Darrell RW | Endogenous Aspergillus uveitis following heart surgery. | 1967 | Arch. Ophthalmol. | pmid:6040013 |
Karaca M et al. | [On an uncommon coagulation defect in patients receiving oral anticoagulants]. | 1967 | Turk Tip Cemiy Mecm | pmid:6082060 |
Gutnick DL et al. | Cis-trans isomerism in naphthoquinones: interconversion and participation in oxidative phosphorylation. | 1967 | Science | pmid:4293760 |
Zanoio L et al. | [On the possibility of preventing the neonatal hypoprothrombinemic crisis by administration of vitamin K1 to the mother before labor]. | 1967 Jan-Feb | Attual Ostet Ginecol | pmid:5602278 |
Lakin KM and Sergeev LV | [Study of the effect of anticoagulants on the kidney function]. | 1967 Sep-Oct | Farmakol Toksikol | pmid:4175312 |
Hamilton JW and Dallam RD | Isolation of vitamin K from animal tissue. | 1968 | Arch. Biochem. Biophys. | pmid:5650316 |
Blomstrand R and Forsgren L | Labelled tocopherols in man. Intestinal absorption and thoracic-duct lymph transport of dl-alpha-tocopheryl-3,4-14C2 acetate dl-alpha-tocopheramine-3,4-14C2 dl-alpha-tocopherol-(5-methyl-3H) and N-(methyl-3H)-dl-gamma-tocopheramine. | 1968 | Int Z Vitaminforsch | pmid:4303536 |