| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakamura E et al. | Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. | 2014 | Nutr J | pmid:25163392 |
| Amaral ME et al. | Effect of vitamin K1 supplementation on left colon healing in rats with extrahepatic biliary obstruction. | 2014 | Acta Cir Bras | pmid:25140594 |
| Farley SM et al. | Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. | 2014 | Mol Nutr Food Res | pmid:25044667 |
| Chao MT et al. | Increase in plasma phylloquinone concentrations following acupoint injection for the treatment of primary dysmenorrhea. | 2014 | J Acupunct Meridian Stud | pmid:24929459 |
| Shea MK et al. | Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults. The Multi-Ethnic Study of Atherosclerosis. | 2014 | Thromb. Haemost. | pmid:24849546 |
| Mi YN et al. | The severe adverse reaction to vitamin k1 injection is anaphylactoid reaction but not anaphylaxis. | 2014 | PLoS ONE | pmid:24594861 |
| Caluwé R et al. | Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. | 2014 | Nephrol. Dial. Transplant. | pmid:24285428 |
| Dalmeijer GW et al. | Phylloquinone concentrations and the risk of vascular calcification in healthy women. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24855054 |
| El-Shabrawi MH and Farrag MI | Hepatic manifestations in juvenile systemic lupus erythematosus. | 2014 | Recent Pat Inflamm Allergy Drug Discov | pmid:24383439 |
| Glatstein M et al. | Emergency use of intravenous phytonadione (vitamin K1) for treatment of severe bleeding in a child with chronic cholestasis. | 2013 Nov-Dec | Am J Ther | pmid:21642829 |
| Jo JC et al. | Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer. | 2013 Jan-Feb | Eur J Dermatol | pmid:23238388 |
| Delmonte P et al. | Modifications ofAOAC Official Method 999.15 to improve the quantitation of vitamin K1 in complex formulated nutritional products. | 2013 Jan-Feb | J AOAC Int | pmid:23513963 |
| Tomková H et al. | Phytomenadione pre-treatment in EGFR inhibitor-induced folliculitis. | 2013 | J Eur Acad Dermatol Venereol | pmid:22035385 |
| Lappe J et al. | Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. | 2013 | Eur J Nutr | pmid:22302614 |
| Savitsky A et al. | Orientation resolving dipolar high-field EPR spectroscopy on disordered solids: II. Structure of spin-correlated radical pairs in photosystem I. | 2013 | J Phys Chem B | pmid:23642108 |
| Juanola-Falgarona M et al. | Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk. | 2013 | Cardiovasc Diabetol | pmid:23298335 |
| McCabe KM et al. | Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. | 2013 | Kidney Int. | pmid:23344475 |
| Laubscher B et al. | Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland. | 2013 | Eur. J. Pediatr. | pmid:23192459 |
| Farley SM et al. | ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol. | 2013 | Mol Nutr Food Res | pmid:23650179 |
| Furt F et al. | Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis. | 2013 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24100308 |