MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Vitamin K Deficiency | D014813 | 5 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bakaev VV and Khomenko VF | [Vitamin K1 and C metabolism in uremia during hemodialysis]. | 1991 Jan-Feb | Urol Nefrol (Mosk) | pmid:1858205 |
Hansen HH | [Practical aspects of peroral anticoagulant treatment]. | 2001 | Ugeskr. Laeg. | pmid:11794049 |
Karaca M et al. | [On an uncommon coagulation defect in patients receiving oral anticoagulants]. | 1967 | Turk Tip Cemiy Mecm | pmid:6082060 |
Iijima T and Nambu M | Effect of combination therapy of vitamin K1 and ursodeoxycholic acid on liver function tests. | 1988 Jul-Aug | Trop Gastroenterol | pmid:3194959 |
Hauska G | Phylloquinone in photosystem I: are quinones the secondary electron acceptors in all types of photosynthetic reaction centers? | 1988 | Trends Biochem. Sci. | pmid:3075361 |
Holzer G et al. | Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. | 2010 | Transl Res | pmid:20621035 |
Alparin JB | Transfusion medicine issues in the practice of anesthesiology. | 1995 | Transfus Med Rev | pmid:8541716 |
Wilson CR et al. | Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. | 2003 | Toxicology | pmid:12832152 |
Tirapelli CR et al. | Vitamin K1 (phylloquinone) induces vascular endothelial dysfunction: role of oxidative stress. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16256160 |
Webster WS et al. | Measurement of DNA damage by the comet assay in rat embryos grown in media containing high concentrations of vitamin K(1). | 2000 | Toxicol In Vitro | pmid:10699366 |