| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin K Deficiency | D014813 | 5 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Exanthema | D005076 | 11 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nimptsch K et al. | Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). | 2008 | Am. J. Clin. Nutr. | pmid:18400723 |
| Jones DY et al. | Vitamin K status of free-living subjects consuming olestra. | 1991 | Am. J. Clin. Nutr. | pmid:2008873 |
| Conly J et al. | Dietary deficiency of phylloquinone and reduced serum levels in febrile neutropenic cancer patients. | 1989 | Am. J. Clin. Nutr. | pmid:2750683 |
| Binkley NC et al. | Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. | 2000 | Am. J. Clin. Nutr. | pmid:11101481 |
| Tsugawa N et al. | Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. | 2006 | Am. J. Clin. Nutr. | pmid:16469998 |
| Fournier B et al. | Variations of phylloquinone concentration in human milk at various stages of lactation and in cow's milk at various seasons. | 1987 | Am. J. Clin. Nutr. | pmid:3825982 |
| Sokoll LJ et al. | Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9062529 |
| Camilo ME et al. | Bioavailability of phylloquinone from an intravenous lipid emulsion. | 1998 | Am. J. Clin. Nutr. | pmid:9537619 |
| Macdonald HM et al. | Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. | 2008 | Am. J. Clin. Nutr. | pmid:18469278 |
| Paiva SA et al. | Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole. | 1998 | Am. J. Clin. Nutr. | pmid:9734750 |
| Kumar R et al. | Effect of phylloquinone supplementation on glucose homeostasis in humans. | 2010 | Am. J. Clin. Nutr. | pmid:20881072 |
| Bieri JG and McKenna MC | Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. | 1981 | Am. J. Clin. Nutr. | pmid:6259921 |
| Saupe J et al. | Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. | 1993 | Am. J. Clin. Nutr. | pmid:8393269 |
| Booth SL et al. | Effects of a hydrogenated form of vitamin K on bone formation and resorption. | 2001 | Am. J. Clin. Nutr. | pmid:11722960 |
| Shea MK et al. | Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. | 2009 | Am. J. Clin. Nutr. | pmid:19776145 |
| Ibarrola-Jurado N et al. | Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. | 2012 | Am. J. Clin. Nutr. | pmid:23034962 |
| Almquist HJ | The early history of vitamin K. | 1975 | Am. J. Clin. Nutr. | pmid:805522 |
| Shea MK et al. | Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. | 2013 | Am. J. Clin. Nutr. | pmid:23719555 |
| Sadowski JA et al. | Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. | 1989 | Am. J. Clin. Nutr. | pmid:2750682 |
| Binkley NC et al. | A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. | 2002 | Am. J. Clin. Nutr. | pmid:12399278 |