MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hashimoto H et al. | A double-blind, placebo-controlled study of the safety and efficacy of vitamin K1 ointment for the treatment of patients with cetuximab-induced acneiform eruption. | 2013 | Jpn. J. Clin. Oncol. | pmid:23136238 |
Schurgers LJ | Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease. | 2013 | Kidney Int. | pmid:23633049 |
Truong JT et al. | Age group and sex do not influence responses of vitamin K biomarkers to changes in dietary vitamin K. | 2012 | J. Nutr. | pmid:22437558 |
Al Rajabi A et al. | Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats. | 2012 | J. Nutr. | pmid:22437559 |
Ginovart N et al. | Chronic Δâ¹-tetrahydrocannabinol exposure induces a sensitization of dopamine Dâ‚‚/₃ receptors in the mesoaccumbens and nigrostriatal systems. | 2012 | Neuropsychopharmacology | pmid:22692568 |
Farley SM et al. | Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone. | 2012 | Mol Nutr Food Res | pmid:22707266 |
Cranenburg EC et al. | Vitamin K intake and status are low in hemodialysis patients. | 2012 | Kidney Int. | pmid:22648294 |
Eugeni Piller L et al. | Plastid lipid droplets at the crossroads of prenylquinone metabolism. | 2012 | J. Exp. Bot. | pmid:22371323 |
Mula S et al. | Introduction of a hydrogen bond between phylloquinone PhQ(A) and a threonine side-chain OH group in photosystem I. | 2012 | J Phys Chem B | pmid:23137346 |
Ibarrola-Jurado N et al. | Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. | 2012 | Am. J. Clin. Nutr. | pmid:23034962 |