MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Otsuka M et al. | Solid dosage form preparations from oily medicines and their drug release. Effect Of degree of surface-modification of silica gel on the drug release from phytonadione-loaded silica gels. | 2000 | J Control Release | pmid:10825568 |
Riou Y et al. | Combined effects of inhaled nitric oxide (iNO) and oxidant agents on the production of methemoglobinemia in newborn piglets. | 2000 | Crit. Care Med. | pmid:10809284 |
Semenov AY et al. | Recruitment of a foreign quinone into the A1 site of photosystem I. Altered kinetics of electron transfer in phylloquinone biosynthetic pathway mutants studied by time-resolved optical, EPR, and electrometric techniques. | 2000 | J. Biol. Chem. | pmid:10801789 |
Chase GW and Thompson B | Accelerated solvent extraction of vitamin K1 in medical foods in conjunction with matrix solid-phase dispersion. | 2000 Mar-Apr | J AOAC Int | pmid:10772179 |
Takata J et al. | Prodrugs for systemic bioreductive activation-independent delivery of phyllohydroquinone, an active form of phylloquinone (vitamin K1). 1: Preparation and in vitro evaluation. | 1999 | Biol. Pharm. Bull. | pmid:10746168 |
Miyakawa T et al. | Vitamin K contents in liver tissue of hepatocellular carcinoma patients. | 2000 | Jpn. J. Cancer Res. | pmid:10744046 |
Zybailov B et al. | Recruitment of a foreign quinone into the A(1) site of photosystem I. II. Structural and functional characterization of phylloquinone biosynthetic pathway mutants by electron paramagnetic resonance and electron-nuclear double resonance spectroscopy. | 2000 | J. Biol. Chem. | pmid:10722691 |
Johnson TW et al. | Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803. | 2000 | J. Biol. Chem. | pmid:10722690 |
Lamnaouer D | [Anticoagulant activity of coumarins from Ferula communis L]. | 1999 Nov-Dec | Therapie | pmid:10709451 |
Webster WS et al. | Measurement of DNA damage by the comet assay in rat embryos grown in media containing high concentrations of vitamin K(1). | 2000 | Toxicol In Vitro | pmid:10699366 |