MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Terahata K and Takahashi A | [The fine structure of liver cells observed after administration of vitamin K 1]. | 1965 | Iryo | pmid:5834547 |
Gutnick DL and Brodie AF | Phosphate-dependent incorporation of tritium into a naphthoquinone during oxidative phosphorylation. | 1965 | J. Biol. Chem. | pmid:5835950 |
Jackman LM et al. | [On the chemistry of vitamin K. 2. Total synthesis and stereochemistry of trans- and cis-(7'R,11'R)-phylloquinone and related compounds]. | 1965 | Helv. Chim. Acta | pmid:5846757 |
Mamont P et al. | [Quinones in oxidative phosphorylation. II. Acid dimerization of K vitamins]. | 1965 | Bull Soc Chim Fr | pmid:5848684 |
Chen LH and Dallam RD | Effect of quinones on mitochondrial phosphorylation, Pi-ATP exchange, and ATPase activities. II. Vitamin K-2 homologues and K-1 derivatives. | 1965 | Arch. Biochem. Biophys. | pmid:4221488 |
SAIDI P et al. | TRANSPLACENTAL TRANSFER OF BISHYDROXYCOUMARIN IN THE HUMAN. | 1965 | JAMA | pmid:14245526 |
CHANDRASEKHAR N et al. | THE EFFECT OF DICUMAROL ON PROTHROMBIN TIME IN RATS AND ITS RELATION TO VITAMIN K CONTENT OF LIVER. | 1965 | Can. J. Physiol. Pharmacol. | pmid:14329349 |
DOUVRES PA | EFFECT OF HIGH PARENTERAL DOSES OF VITAMIN-K ANALOGS AND SERUM ALBUMIN ON THE PROTHROMBIN LEVEL AND LIVER FUNCTION IN ALCOHOLIC CIRRHOSIS. | 1965 | Am J Dig Dis | pmid:14331939 |
ASANO A et al. | MALATE-VITAMIN K REDUCTASE, A PHOSPHOLIPID-REQUIRING ENZYME. | 1965 | J. Biol. Chem. | pmid:14275151 |
HENNINGER MD et al. | COMPARATIVE STUDIES ON PLASTOQUINONES. I. EVIDENCE FOR THREE QUINONES IN THE BLUE-GREEN ALGA, ANACYSTIS NIDULANS. | 1965 | Arch. Biochem. Biophys. | pmid:14321864 |