| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Booth SL et al. | Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. | 1996 | J Am Diet Assoc | pmid:8557941 |
| MacCrehan WA and Schönberger E | Determination of vitamin K1 in serum using catalytic-reduction liquid chromatography with fluorescence detection. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8548011 |
| Alparin JB | Transfusion medicine issues in the practice of anesthesiology. | 1995 | Transfus Med Rev | pmid:8541716 |
| Hallak HO et al. | High clearance of (S)-warfarin in a warfarin-resistant subject. | 1993 | Br J Clin Pharmacol | pmid:8471414 |
| von Kries R and Hanawa Y | Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis. | 1993 | Thromb. Haemost. | pmid:8470054 |
| Conly JM and Stein KE | The absorption and bioactivity of bacterially synthesized menaquinones. | 1993 | Clin Invest Med | pmid:8467580 |
| Pietschnig B et al. | Vitamin K in breast milk: no influence of maternal dietary intake. | 1993 | Eur J Clin Nutr | pmid:8458317 |
| Lennon C et al. | The vitamin K content of intravenous lipid emulsions. | 1993 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:8455316 |
| Gregory EM et al. | Production and some properties of catalase and superoxide dismutase from the anaerobe Bacteroides distasonis. | 1977 | J. Bacteriol. | pmid:845116 |
| Babcock J et al. | Rodenticide-induced coagulopathy in a young child. A case of Munchausen syndrome by proxy. | 1993 | Am J Pediatr Hematol Oncol | pmid:8447555 |
| Sabo A et al. | Red blood cell deformability in diabetes mellitus: effect of phytomenadione. | 1993 | Int J Clin Pharmacol Ther Toxicol | pmid:8444511 |
| Billion-Rey F et al. | Stability of fat-soluble vitamins A (retinol palmitate), E (tocopherol acetate), and K1 (phylloquinone) in total parenteral nutrition at home. | 1993 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:8437325 |
| Lemlich G et al. | Cutaneous reactions to vitamin K1 injections. | 1993 | J. Am. Acad. Dermatol. | pmid:8436655 |
| Bancroft J and Cohen MB | Intracranial hemorrhage due to vitamin K deficiency in breast-fed infants with cholestasis. | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8433245 |
| Guillaumont M et al. | Changes in hepatic vitamin K1 levels after prophylactic administration to the newborn. | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8433228 |
| Anai T et al. | Can prenatal vitamin K1 (phylloquinone) supplementation replace prophylaxis at birth? | 1993 | Obstet Gynecol | pmid:8423960 |
| Bovill EG et al. | Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate. | 1993 | Blood | pmid:8417804 |
| Saupe J et al. | Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. | 1993 | Am. J. Clin. Nutr. | pmid:8393269 |
| Sieckmann I et al. | Transient electron paramagnetic resonance of the triplet state of P700 in photosystem I: evidence for triplet delocalization at room temperature. | 1993 | Biochemistry | pmid:8387818 |
| Cornelissen EA et al. | Prevention of vitamin K deficiency in infancy by weekly administration of vitamin K. | 1993 | Acta Paediatr. | pmid:8374213 |
| Tokumura T et al. | Evaluation of bioavailability upon oral administration of phytonadione preparations in beagle dogs. | 1993 | Biol. Pharm. Bull. | pmid:8364482 |
| Sétif P and Brettel K | Forward electron transfer from phylloquinone A1 to iron-sulfur centers in spinach photosystem I. | 1993 | Biochemistry | pmid:8347589 |
| Groenen-van Dooren MM et al. | The relative effects of phylloquinone and menaquinone-4 on the blood coagulation factor synthesis in vitamin K-deficient rats. | 1993 | Biochem. Pharmacol. | pmid:8347166 |
| Fall D | [Hemorrhagic disease of newborn: vitamin K deficiency]. | 1993 Jan-Feb | Infirmiers | pmid:8324542 |
| Schubiger G et al. | Vitamin K1 concentration in breast-fed neonates after oral or intramuscular administration of a single dose of a new mixed-micellar preparation of phylloquinone. | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8315554 |
| Pastoureau P et al. | Osteopenia and bone-remodeling abnormalities in warfarin-treated lambs. | 1993 | J. Bone Miner. Res. | pmid:8304041 |
| Pengo V et al. | Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation. | 1993 | Blood Coagul. Fibrinolysis | pmid:8292723 |
| Chung JH et al. | Effects of vitamin K1 and menadione on ethanol metabolism and toxicity. | 1993 | Drug Chem Toxicol | pmid:8281891 |
| Hodges SJ et al. | Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. | 1993 | J. Bone Miner. Res. | pmid:8256661 |
| Hollinger BR and Pastoor TP | Case management and plasma half-life in a case of brodifacoum poisoning. | 1993 | Arch. Intern. Med. | pmid:8250654 |
| Cornelissen EA and Monnens LA | [Evaluation of various forms of vitamin-K prophylaxis in breastfed infants]. | 1993 | Ned Tijdschr Geneeskd | pmid:8247166 |
| Fujita K et al. | Vitamin K1 and K2 status and faecal flora in breast fed and formula fed 1-month-old infants. | 1993 | Eur. J. Pediatr. | pmid:8223791 |
| Thijssen HH and Drittij-Reijnders MJ | Vitamin K metabolism and vitamin K1 status in human liver samples: a search for inter-individual differences in warfarin sensitivity. | 1993 | Br. J. Haematol. | pmid:8217828 |
| Hodges SJ et al. | Detection and measurement of vitamins K1 and K2 in human cortical and trabecular bone. | 1993 | J. Bone Miner. Res. | pmid:8213250 |
| Conly JM et al. | The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. | 1994 | Am. J. Gastroenterol. | pmid:8198105 |
| Gupta JM et al. | Neonatal plasma vitamin K1 levels following oral and intramuscular administration of vitamin K1. | 1994 | Acta Paediatr. | pmid:8193487 |
| Breton J et al. | The binding sites of quinones in photosynthetic bacterial reaction centers investigated by light-induced FTIR difference spectroscopy: assignment of the QA vibrations in Rhodobacter sphaeroides using 18O- or 13C-labeled ubiquinone and vitamin K1. | 1994 | Biochemistry | pmid:8161557 |
| Bjornsson TD and Blaschke TF | Vitamin K1 disposition and therapy of warfarin overdose. | 1978 | Lancet | pmid:81403 |
| Sheen SR et al. | Symptomatic brodifacoum ingestion requiring high-dose phytonadione therapy. | 1994 | Vet Hum Toxicol | pmid:8066968 |
| Moënne-Loccoz P et al. | Path of electron transfer in photosystem 1: direct evidence of forward electron transfer from A1 to Fe-Sx. | 1994 | Biochemistry | pmid:8060972 |
| Almquist HJ | The early history of vitamin K. | 1975 | Am. J. Clin. Nutr. | pmid:805522 |
| O'Brien DP et al. | The extent of vitamin K deficiency in patients with cholestatic jaundice: a preliminary communication. | 1994 | J R Soc Med | pmid:8046700 |
| Fackir L et al. | Pulse radiolysis study of vitamin K1 reduction in ethanolic solution. | 1995 | Radiat. Res. | pmid:7997519 |
| Interaction between vitamin K1 and fat absorption. | 1976 | Nutr. Rev. | pmid:794771 | |
| Thijssen HH and Drittij-Reijnders MJ | Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. | 1994 | Br. J. Nutr. | pmid:7947656 |
| Guidetti MS et al. | Sclerodermatous skin reaction after vitamin K1 injections. | 1994 | Contact Derm. | pmid:7924294 |
| Breton J et al. | Binding sites of quinones in photosynthetic bacterial reaction centers investigated by light-induced FTIR difference spectroscopy: binding of chainless symmetrical quinones to the QA site of Rhodobacter sphaeroides. | 1994 | Biochemistry | pmid:7918463 |
| van der Est A et al. | Electron transfer from the acceptor A1 to the iron-sulfur centers in photosystem I as studied by transient EPR spectroscopy. | 1994 | Biochemistry | pmid:7918396 |
| Conly J and Stein K | Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials. | 1994 | Clin Invest Med | pmid:7895417 |
| Roth DA et al. | Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone. | 1995 | J. Biol. Chem. | pmid:7890642 |
| Shearer MJ | Vitamin K. | 1995 | Lancet | pmid:7823718 |
| Sakai I et al. | Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell lines. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802663 |
| Booth SL et al. | Tea and coffee brews are not dietary sources of vitamin K-1 (phylloquinone). | 1995 | J Am Diet Assoc | pmid:7798585 |
| Nakamura K et al. | Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. | 1994 | Artery | pmid:7794122 |
| Maurage C et al. | [Efficacy of oral administration of a micellaar solution of vitamin K during the neonatal period]. | 1995 | Arch Pediatr | pmid:7780540 |
| Bruynzeel I et al. | Cutaneous hypersensitivity reactions to vitamin K: 2 case reports and a review of the literature. | 1995 | Contact Derm. | pmid:7758325 |
| Indyk HE et al. | Liquid chromatographic determination of vitamin K1 in infant formulas and milk. | 1995 May-Jun | J AOAC Int | pmid:7756887 |
| Hara K et al. | The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. | 1995 | Bone | pmid:7756045 |
| Morell A et al. | Morphea-like reaction from vitamin K1. | 1995 | Int. J. Dermatol. | pmid:7751098 |
| Hirsh J and Poller L | Subcutaneous or intravenous phytonadione? | 1995 | Arch. Intern. Med. | pmid:7605163 |
| Feuerbach D et al. | Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption. | 1995 | J. Biol. Chem. | pmid:7592784 |
| Sakamoto N et al. | Changes of K vitamins in portal and femoral venous plasma of rats after oral administration of phylloquinone and menaquinone-4. | 1995 | Int J Vitam Nutr Res | pmid:7591528 |
| Groenen-van Dooren MM et al. | Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. | 1995 | Biochem. Pharmacol. | pmid:7575640 |
| O'Reilly RA and Kearns P | Intravenous vitamin K1 injections: dangerous prophylaxis. | 1995 | Arch. Intern. Med. | pmid:7575074 |
| Dowd P et al. | Vitamin K and energy transduction: a base strength amplification mechanism. | 1995 | Science | pmid:7569894 |
| Huisse MG et al. | Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. | 1994 | Cancer | pmid:7520347 |
| Gessl H et al. | [Reducing lipid peroxidation of stored frozen trout fillet by supplementing feed with vitamin E]. | 1995 | Z Ernahrungswiss | pmid:7502541 |
| Le Guévello P et al. | [Syringes for oral administration of vitamin K1 lipid emulsion]. | 1995 | Arch Pediatr | pmid:7496467 |
| Yen CS and Mack DO | Solubilized rat liver vitamin K carboxylase demonstrates little selectivity between vitamin K1 and the menaquinones. | 1980 | Proc. Soc. Exp. Biol. Med. | pmid:7443718 |
| Haroon Y et al. | Assay of vitamin K1 (phylloquinone) by high performance liquid chromatography: values for human and cow's milk. | 1980 | Proc Nutr Soc | pmid:7403086 |
| Park BK et al. | The dose-dependent effect of warfarin on vitamin K1 metabolism and clotting factor synthesis in the rabbit. | 1980 | Biochem. Pharmacol. | pmid:7396990 |
| Meeks RG and Couri D | Inhibition by warfarin of prothrombin synthesis and of lipid-saccharide synthesis in rat liver. | 1980 | Biochim. Biophys. Acta | pmid:7388053 |
| Elliott GR et al. | Assay procedure for the vitamin K1 2,3-epoxide-reducing system. | 1980 | Meth. Enzymol. | pmid:7366422 |
| Nakata H and Tsuchida E | Determination of vitamin K1 in photodegradation products by gas-liquid chromatography. | 1980 | Meth. Enzymol. | pmid:7366421 |
| Robison JW and Odom RB | Delayed cutaneous reaction to phytonadione. | 1978 | Arch Dermatol | pmid:736587 |
| Carter A et al. | Multiple acquired haemostatic defects. Case report and review of the literature. | 1980 | Haemostasis | pmid:7358321 |
| Sherman PA and Sander EG | Vitamin K epoxide reductase: evidence that vitamin K dihydroquinone is a product of vitamin K epoxide reduction. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7332587 |
| Kolb E | [Recent discoveries on the biochemical significance of vitamin K and some characteristics of vitamin K dependent proteins]. | 1981 | Z Gesamte Inn Med | pmid:7331379 |
| Takahashi O and Hiraga K | Inhibition of phylloquinone epoxide-dependent carboxylation of microsomal proteins from rat liver by 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone. | 1981 | Food Cosmet Toxicol | pmid:7327471 |
| Carlisle DM and Blaschke TF | Vitamin K1, vitamin K1 epoxide and warfarin interrelationships in the dog. | 1981 | Biochem. Pharmacol. | pmid:7317089 |
| McBurney A et al. | Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone in man. | 1980 | Biochem Med | pmid:7306367 |
| Meeks RG and Couri D | The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo. | 1978 | Biochim. Biophys. Acta | pmid:728474 |
| Schultz G et al. | Site of prenylation reaction in synthesis of phylloquinone (vitamin K1) by spinach chloroplasts. | 1981 | Eur. J. Biochem. | pmid:7274213 |
| Bell RG and Ren P | Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation, and the regeneration of vitamin K from vitamin K epoxide. | 1981 | Biochem. Pharmacol. | pmid:7271884 |
| Leck JB and Park BK | A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. | 1981 | Biochem. Pharmacol. | pmid:7236301 |
| Fasco MJ et al. | A new warfarin metabolite: structure and function. | 1978 | J. Med. Chem. | pmid:722713 |
| Chander KS et al. | Effect of reduced vitamin K esters on vitamin K-dependent carboxylation. | 1981 | Biochim. Biophys. Acta | pmid:7213818 |
| Lichtenthaler HK et al. | Localization of prenylquinones in the envelope of spinach chloroplasts. | 1981 | Biochim. Biophys. Acta | pmid:7213720 |
| Fasco MJ and Principe LM | Vitamin K1 hydroquinone formation catalyzed by a microsomal reductase system. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7213374 |
| Breckenridge AM et al. | Mechanisms of action of the anticoagulants warfarin, 2-chloro-3-phytylnaphthoquinone (Cl-K), acenocoumarol, brodifacoum and difenacoum in the rabbit [proceedings]. | 1978 | Br. J. Pharmacol. | pmid:719257 |
| Kilian PL et al. | Reconstitution of acetylcholine receptor from Torpedo Californica with highly purified phospholipids: effect of alpha-tocopherol, phylloquinone, and other terpenoid quinones. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7190011 |
| Rich EC and Drage CW | Severe complications of intravenous phytonadione therapy. Two cases, with one fatality. | 1982 | Postgrad Med | pmid:7134079 |
| Hughes DE | Detection of phytonadione in vegetable oil. | 1982 | J Pharm Sci | pmid:7120078 |
| Hindersin P et al. | [Coagulation physiological controls in subarachnoid hemorrhages and their therapeutic implications]. | 1982 | Psychiatr Neurol Med Psychol (Leipz) | pmid:7100333 |
| Haroon Y et al. | The content of phylloquinone (vitamin K1) in human milk, cows' milk and infant formula foods determined by high-performance liquid chromatography. | 1982 | J. Nutr. | pmid:7086539 |
| Hall AL et al. | Mechanism of action of t-butyl hydroperoxide in the inhibition of vitamin K-dependent carboxylation. | 1982 | Arch. Biochem. Biophys. | pmid:7082011 |
| Bell RG | Vitamin K activity and metabolism of vitamin K-1 epoxide-1,4-diol. | 1982 | J. Nutr. | pmid:7057266 |
| Christe M et al. | [Interaction: Modifast--oral anticoagulation]. | 1983 | Schweiz. Rundsch. Med. Prax. | pmid:6866945 |
| Haroon Y and Hauschka PV | Application of high-performance liquid chromatography to assay phylloquinone (vitamin K1) in rat liver. | 1983 | J. Lipid Res. | pmid:6854154 |
| O'Connor ME et al. | Vitamin K deficiency and breast-feeding. | 1983 | Am. J. Dis. Child. | pmid:6846298 |