| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jo JC et al. | Topical vitamin K1 may not be effective in preventing acneiform rash during cetuximab treatment in patients with metastatic colorectal cancer. | 2013 Jan-Feb | Eur J Dermatol | pmid:23238388 |
| Delmonte P et al. | Modifications ofAOAC Official Method 999.15 to improve the quantitation of vitamin K1 in complex formulated nutritional products. | 2013 Jan-Feb | J AOAC Int | pmid:23513963 |
| Musdal Y et al. | FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1. | 2013 | Chem. Biol. Interact. | pmid:23769903 |
| Kopec RE et al. | Comparison of high-performance liquid chromatography/tandem mass spectrometry and high-performance liquid chromatography/photo-diode array detection for the quantitation of carotenoids, retinyl esters, α-tocopherol and phylloquinone in chylomicron-rich fractions of human plasma. | 2013 | Rapid Commun. Mass Spectrom. | pmid:23681818 |
| Martinis J et al. | A chloroplast ABC1-like kinase regulates vitamin E metabolism in Arabidopsis. | 2013 | Plant Physiol. | pmid:23632854 |
| Lester GE et al. | Summer (subarctic) versus winter (subtropic) production affects spinach (Spinacia oleracea L.) leaf bionutrients: vitamins (C, E, Folate, K1, provitamin A), lutein, phenolics, and antioxidants. | 2013 | J. Agric. Food Chem. | pmid:23834651 |
| Tomková H et al. | Phytomenadione pre-treatment in EGFR inhibitor-induced folliculitis. | 2013 | J Eur Acad Dermatol Venereol | pmid:22035385 |
| Lappe J et al. | Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. | 2013 | Eur J Nutr | pmid:22302614 |
| da Silva AL et al. | Vitamin K1-loaded lipid-core nanocapsules: physicochemical characterization and in vitro skin permeation. | 2013 | Skin Res Technol | pmid:22672012 |
| Marinova M et al. | VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22864379 |
| Hirai K et al. | Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients. | 2013 | Drug Metab. Pharmacokinet. | pmid:22892446 |
| Ibrahim F et al. | Impact of co-administration of protonated nanostructured aluminum silicate (cholesterol absorption inhibitor) on the absorption of lipid soluble vitamins D3 and K1: an assessment of pharmacokinetic and in vitro intraluminal processing. | 2013 | Eur J Pharm Sci | pmid:23454011 |
| Crăciun AM and Vermeer C | Apolipoprotein E genotype may influence urinary gammacarboxyglutamate (Gla) concentrations in young individuals. | 2013 | Gen. Physiol. Biophys. | pmid:23817635 |
| Plank RM et al. | Vitamin K deficiency bleeding and early infant male circumcision in Africa. | 2013 | Obstet Gynecol | pmid:23884276 |
| Reumann S | Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways. | 2013 | Subcell. Biochem. | pmid:23821151 |
| Presse N et al. | Vitamin K status and cognitive function in healthy older adults. | 2013 | Neurobiol. Aging | pmid:23850343 |
| Krigsfeld GS et al. | Mechanism of hypocoagulability in proton-irradiated ferrets. | 2013 | Int. J. Radiat. Biol. | pmid:23651328 |
| Nutescu EA | New approaches to reversing oral anticoagulant therapy. Introduction. | 2013 | Am J Health Syst Pharm | pmid:23640527 |
| Kalus JS | Pharmacologic interventions for reversing the effects of oral anticoagulants. | 2013 | Am J Health Syst Pharm | pmid:23640528 |
| Dager WE | Developing a management plan for oral anticoagulant reversal. | 2013 | Am J Health Syst Pharm | pmid:23640529 |
| McCabe KM et al. | Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease. | 2013 | Kidney Int. | pmid:23344475 |
| Laubscher B et al. | Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland. | 2013 | Eur. J. Pediatr. | pmid:23192459 |
| Busfield A et al. | Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion Neonatal: British Paediatric Surveillance Unit study, 2006-2008. | 2013 | Arch. Dis. Child. | pmid:23148314 |
| Hashimoto H et al. | A double-blind, placebo-controlled study of the safety and efficacy of vitamin K1 ointment for the treatment of patients with cetuximab-induced acneiform eruption. | 2013 | Jpn. J. Clin. Oncol. | pmid:23136238 |
| da Silva FL et al. | Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein. | 2013 | Neurochem. Int. | pmid:23064431 |
| Tanaka KD et al. | A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. | 2013 | J. Vet. Med. Sci. | pmid:23018795 |
| Hegarty JM et al. | UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. | 2013 | Development | pmid:23533172 |
| Shea MK et al. | Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. | 2013 | Am. J. Clin. Nutr. | pmid:23719555 |
| Lopez-Lerma I and Vilaplana J | Contact dermatitis to vitamin K1 in an eye cream. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23987205 |
| Gawroński P et al. | Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana. | 2013 | J. Exp. Bot. | pmid:23956412 |
| Vaccaro JA and Huffman FG | Phylloquinone (vitamin Kâ‚) intake and pulse pressure as a measure of arterial stiffness in older adults. | 2013 | J Nutr Gerontol Geriatr | pmid:23924257 |
| Thom N et al. | Nonuraemic nonfatal idiopathic calciphylaxis in a kitten. | 2013 | Vet. Dermatol. | pmid:23930985 |
| Majeed H et al. | Effect of 200μG/day of vitamin K1 on the variability of anticoagulation control in patients on warfarin: a randomized controlled trial. | 2013 | Thromb. Res. | pmid:23953594 |
| Haraikawa M et al. | Effects of gamma-glutamyl carboxylase gene polymorphism (R325Q) on the association between dietary vitamin K intake and gamma-carboxylation of osteocalcin in young adults. | 2013 | Asia Pac J Clin Nutr | pmid:24231026 |
| Wahlqvist ML et al. | Clinical decision-making for vitamin K-1 and K-2 deficiency and coronary artery calcification with warfarin therapy: are diet, factor Xa inhibitors or both the answer? | 2013 | Asia Pac J Clin Nutr | pmid:24066371 |
| Lovern D and Marbois B | Does menaquinone participate in brain astrocyte electron transport? | 2013 | Med. Hypotheses | pmid:23910074 |
| Krüger T et al. | Warfarin induces cardiovascular damage in mice. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23990204 |
| Meineke I et al. | Routine micromethod for the determination of vitamin K1 in human plasma. | 2013 | Ther Drug Monit | pmid:24089072 |
| D'Alessandro R et al. | Reversibility of regorafenib effects in hepatocellular carcinoma cells. | 2013 | Cancer Chemother. Pharmacol. | pmid:23959464 |
| Lim ZH et al. | The hydrogen-bonded dianion of vitamin K1 produced in aqueous-organic solutions exists in equilibrium with its hydrogen-bonded semiquinone anion radical. | 2013 | J Phys Chem B | pmid:23398469 |
| Beulens JW et al. | The role of menaquinones (vitamin Kâ‚‚) in human health. | 2013 | Br. J. Nutr. | pmid:23590754 |
| Tran HA et al. | An update of consensus guidelines for warfarin reversal. | 2013 | Med. J. Aust. | pmid:23451962 |
| Farley SM et al. | ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol. | 2013 | Mol Nutr Food Res | pmid:23650179 |
| Furt F et al. | Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis. | 2013 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24100308 |
| Schurgers LJ | Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease. | 2013 | Kidney Int. | pmid:23633049 |
| Vissers LE et al. | Intake of dietary phylloquinone and menaquinones and risk of stroke. | 2013 | J Am Heart Assoc | pmid:24326161 |
| Hirota Y et al. | Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. | 2013 | J. Biol. Chem. | pmid:24085302 |
| Viñas P et al. | Dispersive liquid-liquid microextraction for the determination of vitamins D and K in foods by liquid chromatography with diode-array and atmospheric pressure chemical ionization-mass spectrometry detection. | 2013 | Talanta | pmid:24054666 |
| Hanzawa F et al. | Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats. | 2013 | J. Nutr. | pmid:23700348 |
| Wehler TC et al. | Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective. | 2013 | J. Cancer Res. Clin. Oncol. | pmid:23918349 |