| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bandaranayake KM et al. | Time-resolved FTIR difference spectroscopy for the study of photosystem I particles with plastoquinone-9 occupying the A1 binding site. | 2006 | Biochemistry | pmid:17042491 |
| Kaneki M | [Protective effects of vitamin K against osteoporosis and its pleiotropic actions]. | 2006 | Clin Calcium | pmid:16951479 |
| Ali K et al. | Bidirectional electron transfer in photosystem I: replacement of the symmetry-breaking tryptophan close to the PsaB-bound phylloquinone A1B with a glycine residue alters the redox properties of A1B and blocks forward electron transfer at cryogenic temperatures. | 2006 | Biochim. Biophys. Acta | pmid:16989769 |
| Chu PH et al. | Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17164330 |
| Chirputkar SK et al. | Reversal of asymptomatic over-anticoagulation with oral vitamin K. | 2006 | Br. J. Haematol. | pmid:17054668 |
| Liu J et al. | Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants. | 2006 | J Perinat Med | pmid:16519625 |
| Martini LA et al. | Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism. | 2006 | Osteoporos Int | pmid:16547688 |
| Elder SJ et al. | Vitamin k contents of meat, dairy, and fast food in the u.s. Diet. | 2006 | J. Agric. Food Chem. | pmid:16417305 |
| Gumulec J et al. | [Hemorrhagic complications during warfarin treatment]. | 2006 | Vnitr Lek | pmid:16637455 |
| Baker P et al. | Reversal of asymptomatic over-anticoagulation by orally administered vitamin K. | 2006 | Br. J. Haematol. | pmid:16643436 |
| Gross J et al. | A plant locus essential for phylloquinone (vitamin K1) biosynthesis originated from a fusion of four eubacterial genes. | 2006 | J. Biol. Chem. | pmid:16617180 |
| Suhara Y et al. | Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines. | 2006 | Bioorg. Med. Chem. | pmid:16798001 |
| Cockayne S et al. | Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. | 2006 | Arch. Intern. Med. | pmid:16801507 |
| Panis B et al. | Effect of calcium, vitamins K1 and D3 on bone in galactosemia. | 2006 | Bone | pmid:16782422 |
| Kaneki M et al. | Pleiotropic actions of vitamin K: protector of bone health and beyond? | 2006 Jul-Aug | Nutrition | pmid:16815498 |
| Kruger MC et al. | Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. | 2006 Nov-Dec | Nutrition | pmid:17030114 |
| Chawla D et al. | Vitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trial. | 2007 | Indian Pediatr | pmid:18057477 |
| Gutzeit D et al. | Determination of processing effects and of storage stability on vitamin K1 (Phylloquinone) in Sea Buckthorn Berries (Hippophaë rhamnoides L. ssp. rhamnoides) and related products. | 2007 | J. Food Sci. | pmid:18034709 |
| Kamao M et al. | Vitamin K content of foods and dietary vitamin K intake in Japanese young women. | 2007 | J. Nutr. Sci. Vitaminol. | pmid:18202532 |
| Sogabe N et al. | Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats. | 2007 | J. Nutr. Sci. Vitaminol. | pmid:17874826 |
| Schurgers LJ et al. | Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. | 2007 | J. Thromb. Haemost. | pmid:17848178 |
| Azharuddin MK et al. | HPLC method for plasma vitamin K1: effect of plasma triglyceride and acute-phase response on circulating concentrations. | 2007 | Clin. Chem. | pmid:17712007 |
| Karyagina I et al. | Contributions of the protein environment to the midpoint potentials of the A1 phylloquinones and the Fx iron-sulfur cluster in photosystem I. | 2007 | Biochemistry | pmid:17725326 |
| Erkkilä AT et al. | Phylloquinone intake and risk of cardiovascular diseases in men. | 2007 | Nutr Metab Cardiovasc Dis | pmid:16928438 |
| Verberne MC et al. | Vitamin K1 accumulation in tobacco plants overexpressing bacterial genes involved in the biosynthesis of salicylic acid. | 2007 | J. Biotechnol. | pmid:17084477 |
| Wajih N et al. | Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. | 2007 | J. Biol. Chem. | pmid:17124179 |
| Schurgers LJ et al. | Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. | 2007 | Blood | pmid:17158229 |
| Terasaki N et al. | Bio-photosensor: Cyanobacterial photosystem I coupled with transistor via molecular wire. | 2007 | Biochim. Biophys. Acta | pmid:17184727 |
| Pérez-Ruiz T et al. | High-performance liquid chromatography: photochemical reduction in aerobic conditions for determination of K vitamins using fluorescence detection. | 2007 | J Chromatogr A | pmid:17178126 |
| Bolton-Smith C et al. | Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. | 2007 | J. Bone Miner. Res. | pmid:17243866 |
| Hirayama K et al. | Vitamin K deficiency of germfree mice caused by feeding standard purified diet sterilized by gamma-irradiation. | 2007 | Exp. Anim. | pmid:17660681 |
| Bügel S et al. | Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. | 2007 | Br. J. Nutr. | pmid:17298708 |
| Jiang NX et al. | [Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:17961434 |
| Pilkey RM et al. | Subclinical vitamin K deficiency in hemodialysis patients. | 2007 | Am. J. Kidney Dis. | pmid:17336705 |
| Lefebvre-Legendre L et al. | Loss of phylloquinone in Chlamydomonas affects plastoquinone pool size and photosystem II synthesis. | 2007 | J. Biol. Chem. | pmid:17339322 |
| Custódio das Dôres SM et al. | Relationship between diet and anticoagulant response to warfarin: a factor analysis. | 2007 | Eur J Nutr | pmid:17356795 |
| Laible B | Comparison of various phytonadione (vitamin K1) administration routes in achieving warfarin reversal. | 2007 | S D Med | pmid:17555152 |
| Clarke P and Shearer MJ | Vitamin K deficiency bleeding after missed prophylaxis: rapid synergistic effect of vitamin K therapy on hemostasis. | 2007 | South. Med. J. | pmid:17593579 |
| Jin DY et al. | The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. | 2007 | Biochemistry | pmid:17523679 |
| Fluri S et al. | [Hemorrhage in vitamin K deficiency--a preventable entity]. | 2007 | Praxis (Bern 1994) | pmid:17506390 |
| Harrington DJ et al. | Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. | 2007 | J. Nutr. | pmid:17585028 |
| Amunts A et al. | The structure of a plant photosystem I supercomplex at 3.4 A resolution. | 2007 | Nature | pmid:17476261 |
| Ahmed S et al. | Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection. | 2007 | Anal. Chim. Acta | pmid:17481401 |
| Troy LM et al. | Dihydrophylloquinone intake is associated with low bone mineral density in men and women. | 2007 | Am. J. Clin. Nutr. | pmid:17684225 |
| Kozuleva MA et al. | [Participation of ferredoxin in oxygen reduction in a photosynthetic electron-transport chain]. | 2007 Jul-Aug | Biofizika | pmid:17907405 |
| Tasatargil A et al. | Effects of vitamin K1 supplementation on vascular responsiveness and oxidative stress in a rat femoral osteotomy model. | 2007 Sep-Oct | Cell Biochem. Funct. | pmid:16929463 |
| Shea MK and Booth SL | Update on the role of vitamin K in skeletal health. | 2008 | Nutr. Rev. | pmid:18826451 |
| Shearer MJ and Newman P | Metabolism and cell biology of vitamin K. | 2008 | Thromb. Haemost. | pmid:18841274 |
| Song Q et al. | HPLC-APCI-MS for the determination of vitamin K(1) in human plasma: method and clinical application. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18952509 |
| Oostende Cv et al. | Detection and quantification of vitamin K(1) quinol in leaf tissues. | 2008 | Phytochemistry | pmid:18799171 |