| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thielemann H | [Thin layer chromatographic investigations for detection of vitamin K 1 , K 2 and K 3 with 4-aminophenazon]. | 1972 | Mikrochim Acta | pmid:5031031 |
| Druml W et al. | Fat-soluble vitamins in patients with acute renal failure. | 1998 | Miner Electrolyte Metab | pmid:9554560 |
| SOARESFILHO A and BOCIKS J | [PROGESTATIONAL HORMONES AND OTHER COMPOUNDS IN THE TREATMENT OF ABORTION. COMPARATIVE STUDY]. | 1963 | Minerva Ginecol | pmid:14086252 |
| Mautone A et al. | [Evaluation of the efficiency of oral administration of vitamin K1 in neonates at risk for hemorrhagic disease]. | 1987 | Minerva Pediatr. | pmid:3600573 |
| Cappuccini B et al. | [Preliminary study of the possibility of screening for hemorrhagic disease of the newborn by evaluation of the prothrombin complex]. | 1979 | Minerva Pediatr. | pmid:460093 |
| Stiefelhagen P | [Good digestion--essential for blood coagulation. Thrombosis ABC, 17: Vitamin K deficiency and konakion]. | 2000 | MMW Fortschr Med | pmid:10900952 |
| Farley SM et al. | Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion. | 2014 | Mol Nutr Food Res | pmid:25044667 |
| Farley SM et al. | Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone. | 2012 | Mol Nutr Food Res | pmid:22707266 |
| Farley SM et al. | ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol. | 2013 | Mol Nutr Food Res | pmid:23650179 |
| Rehder DS et al. | Gamma-carboxylation and fragmentation of osteocalcin in human serum defined by mass spectrometry. | 2015 | Mol. Cell Proteomics | pmid:25855755 |
| Hadi AH et al. | Influence of plasma total antioxidant ability on lipid and protein oxidation products in plasma and erythrocyte ghost obtained from developing and adult rats pretreated with two vitamin K formulations. | 2004 | Mol. Cell. Biochem. | pmid:15663201 |
| Lorusso DJ and Suttie JW | Warfarin binding to microsomes isolated from normal and warfarin-resistant rat liver. | 1972 | Mol. Pharmacol. | pmid:5025201 |
| McDonald MG et al. | CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant. | 2009 | Mol. Pharmacol. | pmid:19297519 |
| Görög P and Kovács IB | Effects of vitamins K1 and K3 on adenosine nucleotide content of rat tissues. | 1967 | Mol. Pharmacol. | pmid:6052711 |
| Ren P et al. | Effects of warfarin, phenylindanedione, tetrachloropyridinol, and chloro-vitamin K1 on prothrombin synthesis and vitamin K metabolism in normal and warfarin-resistant rats. | 1974 | Mol. Pharmacol. | pmid:4851787 |
| Huang ZR et al. | Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. | 2009 | Molecules | pmid:19169201 |
| Mühlendahl KE et al. | [Intoxication with anticoagulant rodenticides (author's transl)]. | 1979 | Monatsschr Kinderheilkd | pmid:423905 |
| POMERANITZ N et al. | HEMORRHAGIC DIATHESIS DUE TO SALICYLATE-INDUCED HYPOPROTHROMBINEMIA. | 1964 | N Y State J Med | pmid:14130796 |
| Birkbeck JA | Vitamin K prophylaxis in the newborn: a position statement of the Nutrition Committee of the Paediatric Society of New Zealand. | 1988 | N. Z. Med. J. | pmid:3393332 |
| Yasunaga K | [Comparative studies on the effectiveness of vitamin K1 and vitamin K2]. | 1970 | Naika Hokan | pmid:5531458 |
| Shen G et al. | Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer. | 2017 | Nat. Struct. Mol. Biol. | pmid:27918545 |
| Bell RG and Matschiner JT | Warfarin and the inhibition of vitamin K activity by an oxide metabolite. | 1972 | Nature | pmid:4555434 |
| Ben-Shem A et al. | Crystal structure of plant photosystem I. | 2003 | Nature | pmid:14668855 |
| Nakagawa K et al. | Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. | 2010 | Nature | pmid:20953171 |
| Anderson SS et al. | Electron transfer across membranes using vitamin K1 and coenzyme Q10 as carrier molecules. | 1976 | Nature | pmid:1246352 |
| MCKENNA M et al. | A SECOND NAPHTHOQUINONE IN SPINACH CHLOROPLASTS. | 1964 | Nature | pmid:14202379 |
| Amunts A et al. | The structure of a plant photosystem I supercomplex at 3.4 A resolution. | 2007 | Nature | pmid:17476261 |
| Eichbaum FW et al. | Anti-inflammatory effect of warfarin and vitamin K1. | 1979 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:573373 |
| Cornelissen EA and Monnens LA | [Evaluation of various forms of vitamin-K prophylaxis in breastfed infants]. | 1993 | Ned Tijdschr Geneeskd | pmid:8247166 |
| Jansen RW et al. | [Too much haste is not good either with vitamin K]. | 1990 | Ned Tijdschr Geneeskd | pmid:2215714 |
| Reichel H | No effect of vitamin K1 supplementation on biochemical bone markers in haemodialysis patients. | 1999 | Nephrol. Dial. Transplant. | pmid:10052531 |
| Caluwé R et al. | Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. | 2014 | Nephrol. Dial. Transplant. | pmid:24285428 |
| KIENLE G | [ANALEPTIC TREATMENT OF THE ALCOHOLIC DELIRIUM]. | 1964 | Nervenarzt | pmid:14155671 |
| Presse N et al. | Vitamin K status and cognitive function in healthy older adults. | 2013 | Neurobiol. Aging | pmid:23850343 |
| da Silva FL et al. | Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein. | 2013 | Neurochem. Int. | pmid:23064431 |
| Ginovart N et al. | Chronic Δâ¹-tetrahydrocannabinol exposure induces a sensitization of dopamine Dâ‚‚/₃ receptors in the mesoaccumbens and nigrostriatal systems. | 2012 | Neuropsychopharmacology | pmid:22692568 |
| McCormick PN et al. | The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro. | 2010 | Neuropsychopharmacology | pmid:20410873 |
| Tsang CK and Kamei Y | Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. | 2002 | Neurosci. Lett. | pmid:11911978 |
| Katsuyama N | [Electron microscopic study on the effect of vitamins E and K1, anabolic steroids and adrenal cortex hormones on experimental liver diseases of dietary origin]. | 1969 | Nihon Shonika Gakkai Zasshi | pmid:5388710 |
| OMORI A | [ANTIHEMOPHILIC GLOBULIN CONSUMPTION DURING BLOOD COAGULATION]. | 1963 | Nippon Naika Gakkai Zasshi | pmid:14156201 |
| Kimura I et al. | [Multiple drug therapy of malignant tumor using fibroblast-suppresive agents as the basis]. | 1970 | Nippon Rinsho | pmid:5466668 |
| Shirahata A | [Vitamin K compounds]. | 2004 | Nippon Rinsho | pmid:15658294 |
| Saga K and Terao T | [Studies on transfer of vitamin K into human breast milk]. | 1989 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:2592801 |
| Hata Y | [Vitamin K in obstetrics--effects of vitamin K1 on threatened abortion and premature labor]. | 1967 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:5627227 |
| Tajima T et al. | [Therapeutic effect of menaquinone-4 (K2) on hypoprothrombinemia caused by warfarin]. | 1971 | Nippon Yakurigaku Zasshi | pmid:5165263 |
| Tajima T et al. | [Preventive effect of menaquinone-4 (K2) on hypoprothrombinemia caused by dicumarol]. | 1971 | Nippon Yakurigaku Zasshi | pmid:4107009 |
| Tajima TO et al. | [Hemostatic effects of menaquinone-4 (K2) on various types of hemorrhagic diathesis in rats and comparison with other hemostatic agents]. | 1971 | Nippon Yakurigaku Zasshi | pmid:4110973 |
| Cohen MR | Medication errors. | 2010 | Nursing | pmid:20016317 |
| Ikari Y et al. | Impact of menaquinone-4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study. | 2016 | Nutr J | pmid:27175730 |
| Nakamura E et al. | Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. | 2014 | Nutr J | pmid:25163392 |