| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Finney LA and Gholston D | Cerebral aneurysm rupture during anticoagulant therapy with survival. | 1967 | JAMA | pmid:6071662 |
| Jones B | Negative effects of vitamin K preparations on glucuronyl transferase activity. | 1967 | Pediatrics | pmid:6074140 |
| Karaca M et al. | [On an uncommon coagulation defect in patients receiving oral anticoagulants]. | 1967 | Turk Tip Cemiy Mecm | pmid:6082060 |
| Trenk D et al. | Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. | 1980 | J. Pharm. Pharmacol. | pmid:6110746 |
| Park BK and Leck JB | On the mechanism of salicylate-induced hypothrombinaemia. | 1981 | J. Pharm. Pharmacol. | pmid:6114147 |
| Shearer MJ et al. | Plasma vitamin K1 in mothers and their newborn babies. | 1982 | Lancet | pmid:6125638 |
| Dunn PM | Vitamin K1 for all newborn babies. | 1982 | Lancet | pmid:6125839 |
| Bechtold H et al. | Plasma vitamin K1-2,3-epoxide as diagnostic aid to detect surreptitious ingestion of oral anticoagulant drug. | 1983 | Lancet | pmid:6131291 |
| Bailey RR | Bleeding tendency in patients on cephalosporins. | 1983 | Lancet | pmid:6132156 |
| Bridgman GC | Prophylactic vitamin K and haemorrhagic disease of the newborn. | 1983 | Lancet | pmid:6134071 |
| Hildebrandt EF and Suttie JW | The effects of salicylate on enzymes of vitamin K metabolism. | 1983 | J. Pharm. Pharmacol. | pmid:6136582 |
| Hart JP et al. | Circulating vitamin K1 levels in fractured neck of femur. | 1984 | Lancet | pmid:6146829 |
| Nagata M et al. | Coagulation recovery after warfarin-induced hypoprothrombinaemia by oral administration of liposomally-associated vitamin K1 to rabbits. | 1984 | J. Pharm. Pharmacol. | pmid:6148395 |
| Hildebrandt E and Suttie JW | Indirect inhibition of vitamin K epoxide reduction by salicylate. | 1984 | J. Pharm. Pharmacol. | pmid:6149281 |
| Seeler RA and Reitan J | Cephalosporin induced coagulopathies. | 1984 | IMJ Ill Med J | pmid:6150914 |
| McBurney A et al. | Changes in the urinary metabolites of phylloquinone (vitamin K1) in man following therapeutic anticoagulation with warfarin. | 1978 | Biochem. Pharmacol. | pmid:619911 |
| Hollander D and Rim E | Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. | 1978 | Am. J. Physiol. | pmid:623249 |
| Bieri JG and McKenna MC | Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. | 1981 | Am. J. Clin. Nutr. | pmid:6259921 |
| Sloane N | Enzymic hydroxylation of benzo(alpha)pyrene at the 6-position by vitamin K1-hydroperoxide and rat lung hydroperoxidase. | 1981 | Xenobiotica | pmid:6272502 |
| Israels LG et al. | Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice. | 1983 | J. Clin. Invest. | pmid:6304144 |
| Conversion of vitamin K epoxide to hydroxyvitamin K by liver microsomes from warfarin-resistant rats. | 1983 | Nutr. Rev. | pmid:6355923 | |
| Megavitamin E supplementation and vitamin K-dependent carboxylation. | 1983 | Nutr. Rev. | pmid:6358960 | |
| Olson RE | The function and metabolism of vitamin K. | 1984 | Annu. Rev. Nutr. | pmid:6380538 |
| van Amstel WJ et al. | Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin k1. | 1978 | Blut | pmid:638263 |
| Vitamin K hydroperoxide: an intermediate in gamma-glutamate carboxylation? | 1984 | Nutr. Rev. | pmid:6384837 | |
| Hanck A and Weiser H | Physiological and pharmacological effects of vitamin K. | 1983 | Int J Vitam Nutr Res Suppl | pmid:6414967 |
| Kutsop JJ | Update on vitamin K1 content of enteral products. | 1984 | Am J Hosp Pharm | pmid:6437219 |
| Goldschmidt B et al. | [Vitamin K-dependent coagulation factors in neonates during total parenteral nutrition]. | 1984 | Orv Hetil | pmid:6440072 |
| Hart JA et al. | A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits. | 1984 | Biochem. Pharmacol. | pmid:6487353 |
| Napoli JL and Beck CD | Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis. | 1984 | Biochem. J. | pmid:6497842 |
| Park BK et al. | Plasma disposition of vitamin K1 in relation to anticoagulant poisoning. | 1984 | Br J Clin Pharmacol | pmid:6508974 |
| Haustein KO | Interaction between phenprocoumon and phytomenadion: a pharmacokinetic investigation in healthy volunteers. | 1984 | Biomed. Biochim. Acta | pmid:6534380 |
| McGehee WG et al. | Coumarin necrosis associated with hereditary protein C deficiency. | 1984 | Ann. Intern. Med. | pmid:6547283 |
| Bechtold H et al. | Evidence for impaired hepatic vitamin K1 metabolism in patients treated with N-methyl-thiotetrazole cephalosporins. | 1984 | Thromb. Haemost. | pmid:6548584 |
| Garvey WT and Olson RE | In vitro vitamin K-dependent conversion of precursor to prothrombin in chick liver. | 1978 | J. Nutr. | pmid:660301 |
| Horn GB | Determination of phytonadione in elemental diets by TLC-spectrophotodensitometry. | 1978 | J Pharm Sci | pmid:660469 |
| Shanahan F et al. | Factor V deficiency and its reversal with gluten restriction. In a patient with celiac disease. | 1983 | Arch. Intern. Med. | pmid:6625791 |
| Kammermann-Lüscher B | [Coumarin poisoning in dog and cat]. | 1978 | Schweiz. Arch. Tierheilkd. | pmid:663601 |
| Ueno T and Suttie JW | High-pressure liquid chromatographic-reductive electrochemical detection analysis of serum trans-phylloquinone. | 1983 | Anal. Biochem. | pmid:6638487 |
| O'Mara K and Mavichak V | Trauma and oral anticoagulants. | 1983 | Ann Emerg Med | pmid:6638631 |
| Boster SR and Bergin JJ | Upper airway obstruction complicating warfarin therapy--with a note on reversal of warfarin toxicity. | 1983 | Ann Emerg Med | pmid:6638633 |
| Chang JC | Acquired coagulopathy owing to parenteral cefamandole: renal failure as a predisposing factor. | 1983 Sep-Oct | Ann. Clin. Lab. Sci. | pmid:6638932 |
| Pennock JF | The biosynthesis of chloroplastidic terpenoid quinones and chromanols. | 1983 | Biochem. Soc. Trans. | pmid:6642059 |
| Wilson AC and Park BK | Quantitative analysis of pharmacological levels of vitamin K1 and vitamin K1 2,3-epoxide in rabbit plasma by high-performance liquid chromatography. | 1983 | J. Chromatogr. | pmid:6643613 |
| Fasco MJ et al. | Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes. | 1983 | Biochemistry | pmid:6652076 |
| Kutsop JJ | Vitamin K1 content of enteral products. | 1983 | Am J Hosp Pharm | pmid:6660224 |
| Bechtold H et al. | Cyclic interconversion of vitamin K1 and vitamin K1 2,3-epoxide in man. | 1983 | Br J Clin Pharmacol | pmid:6661354 |
| Mount ME and Feldman BF | Mechanism of diphacinone rodenticide toxicosis in the dog and its therapeutic implications. | 1983 | Am. J. Vet. Res. | pmid:6689111 |
| Kanabus-Kaminska JM and Girardot JM | Inhibition of vitamin K-dependent carboxylase by metal ions and metal complexes: a reassessment. | 1984 | Arch. Biochem. Biophys. | pmid:6696452 |
| Wilson AC and Park BK | The effect of phenobarbitone pre-treatment on vitamin K1 disposition in the rat and rabbit. | 1984 | Biochem. Pharmacol. | pmid:6704138 |