| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| CHALMERS JN et al. | Antagonistic effect of oral vitamin K1 on the action of ethyl biscoumacetate and phenylindanedione. | 1954 | Br Med J | pmid:13199354 |
| pmid:13188641 | ||||
| pmid:13138172 | ||||
| pmid:13079849 | ||||
| GUTTAS CG et al. | Studies on the anticoagulant phenylindanedione. I. The effect of emulsified vitamin K1 on phenylindanedione-induced hypoprothrombinemia. | 1953 | Blood | pmid:13032197 |
| pmid:13002683 | ||||
| Preusch PC | Is thioredoxin the physiological vitamin K epoxide reducing agent? | 1992 | FEBS Lett. | pmid:1299627 |
| Kimura S et al. | The roles of intestinal flora and intestinal function on vitamin K metabolism. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297781 |
| Tanimura H and Tsuji T | Serum and liver concentrations of vitamin K in surgical patients. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297779 |
| Shearer MJ et al. | Comparative aspects of human vitamin K metabolism and nutriture. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297778 |
| Rybnikov VN and Brovkina IL | [Correlation of immunomodulating effects induced by lysozyme and naphthoquinones in acute blood loss]. | 2003 | Antibiot. Khimioter. | pmid:12968462 |
| Lamson DW and Plaza SM | The anticancer effects of vitamin K. | 2003 | Altern Med Rev | pmid:12946240 |
| Sato T et al. | The biological activity and tissue distribution of 2',3'-dihydrophylloquinone in rats. | 2003 | Biochim. Biophys. Acta | pmid:12928110 |
| Poli D et al. | Asymptomatic excessive coumarin anticoagulation is a risk factor for thrombotic and bleeding complications of oral anticoagulant therapy. | 2003 | J. Thromb. Haemost. | pmid:12911603 |
| Kurilich AC et al. | Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea). | 2003 | J. Agric. Food Chem. | pmid:12903939 |
| Hansen KN et al. | Weekly oral vitamin K prophylaxis in Denmark. | 2003 | Acta Paediatr. | pmid:12892158 |
| Booth SL et al. | Dietary phylloquinone depletion and repletion in older women. | 2003 | J. Nutr. | pmid:12888638 |
| Li J et al. | Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. | 2003 | J. Neurosci. | pmid:12843286 |
| Wilson CR et al. | Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. | 2003 | Toxicology | pmid:12832152 |
| Wakabayashi H et al. | Simultaneous determination of vitamin K analogs in human serum by sensitive and selective high-performance liquid chromatography with electrochemical detection. | 2003 Jul-Aug | Nutrition | pmid:12831955 |
| Hangarter MA et al. | Primary photoreactions of phylloquinone (vitamin K1) and plastoquinone-1 in solution. | 2003 | Photochem. Photobiol. Sci. | pmid:12803075 |
| Lange BM and Ghassemian M | Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. | 2003 | Plant Mol. Biol. | pmid:12777052 |
| Xu W et al. | Electron transfer in cyanobacterial photosystem I: II. Determination of forward electron transfer rates of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX. | 2003 | J. Biol. Chem. | pmid:12721306 |
| Agalarov R and Brettel K | Temperature dependence of biphasic forward electron transfer from the phylloquinone(s) A1 in photosystem I: only the slower phase is activated. | 2003 | Biochim. Biophys. Acta | pmid:12686416 |
| Markovits J et al. | Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells. | 2003 | Life Sci. | pmid:12679193 |
| Gong XM et al. | Control of electron transport in photosystem I by the iron-sulfur cluster FX in response to intra- and intersubunit interactions. | 2003 | J. Biol. Chem. | pmid:12626505 |
| Wade Johnson T et al. | The menD and menE homologs code for 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylate synthase and O-succinylbenzoic acid-CoA synthase in the phylloquinone biosynthetic pathway of Synechocystis sp. PCC 6803. | 2003 | Biochim. Biophys. Acta | pmid:12615349 |
| Blake CJ | Committee on food nutrition. Fat-soluble vitamins. | 2003 Jan-Feb | J AOAC Int | pmid:12607754 |
| Poli D et al. | Safety and effectiveness of low dose oral vitamin K1 administration in asymptomatic out-patients on warfarin or acenocoumarol with excessive anticoagulation. | 2003 | Haematologica | pmid:12604423 |
| Pereira SP et al. | Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12598499 |
| Essalihi R et al. | A new model of isolated systolic hypertension induced by chronic warfarin and vitamin K1 treatment. | 2003 | Am. J. Hypertens. | pmid:12559675 |
| Golbeck JH | The binding of cofactors to photosystem I analyzed by spectroscopic and mutagenic methods. | 2003 | Annu Rev Biophys Biomol Struct | pmid:12524325 |
| Shinkarev VP et al. | Modeling of the P700+ charge recombination kinetics with phylloquinone and plastoquinone-9 in the A1 site of photosystem I. | 2002 | Biophys. J. | pmid:12496065 |
| Anderson SS et al. | Electron transfer across membranes using vitamin K1 and coenzyme Q10 as carrier molecules. | 1976 | Nature | pmid:1246352 |
| Tirapelli CR et al. | Vitamin K1 attenuates hypoxia-induced relaxation of rat carotid artery. | 2002 | Pharmacol. Res. | pmid:12457620 |
| Lindquist J and Farroha SM | Application of differential pulse polarography to the assay of vitamins. | 1975 | Analyst | pmid:124542 |
| Shimizu N et al. | Shift of serum osteocalcin components between cord blood and blood at day 5 of life. | 2002 | Pediatr. Res. | pmid:12409510 |
| Binkley NC et al. | A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. | 2002 | Am. J. Clin. Nutr. | pmid:12399278 |
| Riegert-Johnson DL and Volcheck GW | The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12392385 |
| Fregin A et al. | Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. | 2002 | Blood | pmid:12384421 |
| Rigby SE et al. | Photoaccumulation of the PsaB phyllosemiquinone in photosystem I of Chlamydomonas reinhardtii. | 2002 | Biochim. Biophys. Acta | pmid:12351214 |
| Booth SL et al. | Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women. | 2002 | J. Nutr. | pmid:12221218 |
| Cook KK et al. | Measurement of cis and trans isomers of vitamin K1 in rat tissues by liquid chromatography with a C30 column. | 2002 Jul-Aug | J AOAC Int | pmid:12180675 |
| Roe DE et al. | Multilaboratory comparison of anaerobe susceptibility results using 3 different agar media. | 2002 | Clin. Infect. Dis. | pmid:12173107 |
| Roe DE et al. | Multilaboratory comparison of growth characteristics for anaerobes, using 5 different agar media. | 2002 | Clin. Infect. Dis. | pmid:12173106 |
| pmid:12172322 | ||||
| Tirapelli CR et al. | Vitamin K(1) prevents the effect of hypoxia on phenylephrine-induced contraction in the carotid artery. | 2002 | Pharmacology | pmid:12169764 |
| Dähnhardt D et al. | The hydroxyphenylpyruvate dioxygenase from Synechocystis sp. PCC 6803 is not required for plastoquinone biosynthesis. | 2002 | FEBS Lett. | pmid:12123828 |
| Woollard DC et al. | Determination of vitamin K1 isomers in foods by liquid chromatography with C30 bonded-phase column. | 2002 May-Jun | J AOAC Int | pmid:12083261 |
| Thane CW et al. | Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people. | 2002 | Br. J. Nutr. | pmid:12067432 |