| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kumar R et al. | Effect of phylloquinone supplementation on glucose homeostasis in humans. | 2010 | Am. J. Clin. Nutr. | pmid:20881072 |
| Nakagawa K et al. | Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. | 2010 | Nature | pmid:20953171 |
| Heggen E et al. | Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. | 2010 | Nutr Metab Cardiovasc Dis | pmid:19748247 |
| Lester GE et al. | gamma-Irradiation dose: effects on baby-leaf spinach ascorbic acid, carotenoids, folate, alpha-tocopherol, and phylloquinone concentrations. | 2010 | J. Agric. Food Chem. | pmid:20329797 |
| Nimptsch K et al. | Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). | 2010 | Am. J. Clin. Nutr. | pmid:20335553 |
| Chuansumrit A et al. | Prevalence of subclinical vitamin K deficiency in Thai newborns: relationship to maternal phylloquinone intakes and delivery risk. | 2010 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:19822527 |
| Showalter SL et al. | Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway. | 2010 | J. Gastroenterol. Hepatol. | pmid:19929921 |
| Yuen E et al. | Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. | 2010 | J Pharmacokinet Pharmacodyn | pmid:19941044 |
| Cohen MR | Medication errors. | 2010 | Nursing | pmid:20016317 |
| Holick MF et al. | Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. | 2010 | J. Bone Miner. Metab. | pmid:20024591 |
| Beulens JW et al. | Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. | 2010 | Diabetes Care | pmid:20424220 |
| Holden RM et al. | Vitamins K and D status in stages 3-5 chronic kidney disease. | 2010 | Clin J Am Soc Nephrol | pmid:20167683 |
| Sauberan JB et al. | Origins of and solutions for neonatal medication-dispensing errors. | 2010 | Am J Health Syst Pharm | pmid:20044369 |
| Schimpf KJ et al. | Determination of trans vitamin K1 in infant and medical nutritional products using AOAC Method 999.15 with modified preparation and extraction procedures and C30 bonded phase chromatography: single-laboratory validation. | 2010 Mar-Apr | J AOAC Int | pmid:20480913 |
| Kanai S et al. | Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats. | 2011 | Atherosclerosis | pmid:21193197 |
| Eugeni Piller L et al. | Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21844348 |
| Stork CM et al. | Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy. | 2011 | Am J Health Syst Pharm | pmid:21593229 |
| Fusaro M et al. | Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship. | 2011 | J. Endocrinol. Invest. | pmid:21088475 |
| Braga CB et al. | Serum vitamins in adult patients with short bowel syndrome receiving intermittent parenteral nutrition. | 2011 | JPEN J Parenter Enteral Nutr | pmid:21628608 |
| Lamb JJ et al. | Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₠produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. | 2011 | Nutr Res | pmid:21636012 |
| Carrié I et al. | Lifelong low-phylloquinone intake is associated with cognitive impairments in old rats. | 2011 | J. Nutr. | pmid:21653572 |
| Westhofen P et al. | Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. | 2011 | J. Biol. Chem. | pmid:21367861 |
| Nakano T et al. | High prevalence of hypovitaminosis D and K in patients with hip fracture. | 2011 | Asia Pac J Clin Nutr | pmid:21393111 |
| Srinivasan N et al. | Effect of hydrogen bond strength on the redox properties of phylloquinones: a two-dimensional hyperfine sublevel correlation spectroscopy study of photosystem I. | 2011 | Biochemistry | pmid:21476509 |
| Lee R et al. | Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer. | 2011 | Am J Health Syst Pharm | pmid:21515865 |
| Rishavy MA et al. | Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation. | 2011 | J. Biol. Chem. | pmid:20978134 |
| Sogabe N et al. | Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. | 2011 | Bone | pmid:21295170 |
| Srinivasan N et al. | Alteration of the H-bond to the A(1A) phylloquinone in Photosystem I: influence on the kinetics and energetics of electron transfer. | 2011 | J Phys Chem B | pmid:21299208 |
| Tie JK et al. | Functional study of the vitamin K cycle in mammalian cells. | 2011 | Blood | pmid:21239697 |
| Terachi T et al. | Plasma vitamin K concentration in horses supplemented with several vitamin K homologs. | 2011 | J. Anim. Sci. | pmid:21169510 |
| Suhara Y et al. | Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K. | 2011 | J. Med. Chem. | pmid:21618996 |
| Carr BI et al. | Differential effects of vitamin K1 on AFP and DCP levels in patients with unresectable HCC and in HCC cell lines. | 2011 | Dig. Dis. Sci. | pmid:21188521 |
| Gebuis EP et al. | Vitamin K1 supplementation to improve the stability of anticoagulation therapy with vitamin K antagonists: a dose-finding study. | 2011 | Haematologica | pmid:21193422 |
| McConnell MD et al. | Double reduction of plastoquinone to plastoquinol in photosystem 1. | 2011 | Biochemistry | pmid:22103567 |
| Haraikawa M et al. | Vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) induces intestinal alkaline phosphatase gene expression. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:22041909 |
| Clark TR and Burns S | Elevated international normalized ratio values associated with concomitant use of warfarin and ceftriaxone. | 2011 | Am J Health Syst Pharm | pmid:21856805 |
| Apalset EM et al. | Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. | 2011 | Bone | pmid:21839190 |
| Ito A et al. | Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. | 2011 | Lipids Health Dis | pmid:21914161 |
| Carr BI et al. | c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. | 2011 | Cancer Biol. Ther. | pmid:21734462 |
| Stevenson MD and Jones ML | The cost effectiveness of a randomized controlled trial to establish the relative efficacy of vitamin K1 compared with alendronate. | 2011 Jan-Feb | Med Decis Making | pmid:20375420 |
| Du W et al. | Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway. | 2012 | World J Surg Oncol | pmid:22520038 |
| Suni NM et al. | Analysis of lipids with desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS) and desorption electrospray ionization-mass spectrometry (DESI-MS). | 2012 | J Mass Spectrom | pmid:22576874 |
| Presse N et al. | A single measurement of serum phylloquinone is an adequate indicator of long-term phylloquinone exposure in healthy older adults. | 2012 | J. Nutr. | pmid:22915296 |
| O'Seaghdha CM et al. | Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. | 2012 | Am. J. Nephrol. | pmid:22722822 |
| Lembo S et al. | "Cowboy's belt with revolver" scleroderma caused by vitamin K1 injections. | 2012 | G Ital Dermatol Venereol | pmid:22481583 |
| Shea MK et al. | Circulating phylloquinone concentrations of adults in the United States differ according to race and ethnicity. | 2012 | J. Nutr. | pmid:22496402 |
| Shea MK and Holden RM | Vitamin K status and vascular calcification: evidence from observational and clinical studies. | 2012 | Adv Nutr | pmid:22516723 |
| Shearer MJ et al. | Vitamin K nutrition, metabolism, and requirements: current concepts and future research. | 2012 | Adv Nutr | pmid:22516726 |
| Mula S et al. | Introduction of a hydrogen bond between phylloquinone PhQ(A) and a threonine side-chain OH group in photosystem I. | 2012 | J Phys Chem B | pmid:23137346 |
| Scibona P et al. | Prevalence of CYP2C9 and VKORC1 alleles in the Argentine population and implications for prescribing dosages of anticoagulants. | 2012 | Genet. Mol. Res. | pmid:22290467 |