| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guillaumont M et al. | Changes in hepatic vitamin K1 levels after prophylactic administration to the newborn. | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8433228 |
| Bancroft J and Cohen MB | Intracranial hemorrhage due to vitamin K deficiency in breast-fed infants with cholestasis. | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8433245 |
| Lemlich G et al. | Cutaneous reactions to vitamin K1 injections. | 1993 | J. Am. Acad. Dermatol. | pmid:8436655 |
| Billion-Rey F et al. | Stability of fat-soluble vitamins A (retinol palmitate), E (tocopherol acetate), and K1 (phylloquinone) in total parenteral nutrition at home. | 1993 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:8437325 |
| Sabo A et al. | Red blood cell deformability in diabetes mellitus: effect of phytomenadione. | 1993 | Int J Clin Pharmacol Ther Toxicol | pmid:8444511 |
| Babcock J et al. | Rodenticide-induced coagulopathy in a young child. A case of Munchausen syndrome by proxy. | 1993 | Am J Pediatr Hematol Oncol | pmid:8447555 |
| Gregory EM et al. | Production and some properties of catalase and superoxide dismutase from the anaerobe Bacteroides distasonis. | 1977 | J. Bacteriol. | pmid:845116 |
| Lennon C et al. | The vitamin K content of intravenous lipid emulsions. | 1993 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:8455316 |
| Pietschnig B et al. | Vitamin K in breast milk: no influence of maternal dietary intake. | 1993 | Eur J Clin Nutr | pmid:8458317 |
| Conly JM and Stein KE | The absorption and bioactivity of bacterially synthesized menaquinones. | 1993 | Clin Invest Med | pmid:8467580 |
| von Kries R and Hanawa Y | Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis. | 1993 | Thromb. Haemost. | pmid:8470054 |
| Hallak HO et al. | High clearance of (S)-warfarin in a warfarin-resistant subject. | 1993 | Br J Clin Pharmacol | pmid:8471414 |
| Alparin JB | Transfusion medicine issues in the practice of anesthesiology. | 1995 | Transfus Med Rev | pmid:8541716 |
| MacCrehan WA and Schönberger E | Determination of vitamin K1 in serum using catalytic-reduction liquid chromatography with fluorescence detection. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8548011 |
| Booth SL et al. | Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. | 1996 | J Am Diet Assoc | pmid:8557941 |
| Kuijpers EA et al. | A method for the simultaneous identification and quantitation of five superwarfarin rodenticides in human serum. | 1995 Nov-Dec | J Anal Toxicol | pmid:8577178 |
| Barkhan P and Shearer MJ | Metabolism of vitamin K1 (phylloquinone) in man. | 1977 | Proc. R. Soc. Med. | pmid:859820 |
| Sokoll LJ and Sadowski JA | Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. | 1996 | Am. J. Clin. Nutr. | pmid:8599321 |
| Kohlmeier M et al. | Variation of phylloquinone (vitamin K1) concentrations in hemodialysis patients. | 1995 | Thromb. Haemost. | pmid:8607104 |
| Kameda T et al. | Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607797 |
| Thijssen HH et al. | Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations. | 1996 | J. Nutr. | pmid:8632229 |
| Heathcote P et al. | Photoaccumulation in photosystem I does produce a phylloquinone (A1.-) radical. | 1996 | Biochemistry | pmid:8639613 |
| Rigby SE et al. | ENDOR and special triple resonance spectroscopy of A1.- of photosystem 1. | 1996 | Biochemistry | pmid:8639614 |
| Shearer MJ et al. | Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. | 1996 | J. Nutr. | pmid:8642453 |
| Sugiura I et al. | Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis. | 1996 | J. Biol. Chem. | pmid:8663364 |
| Harrell CC and Kline SS | Oral vitamin K1: an option to reduce warfarin's activity. | 1995 | Ann Pharmacother | pmid:8672826 |
| Roberts NB et al. | Serial changes in serum vitamin K1, triglyceride, cholesterol, osteocalcin and 25-hydroxyvitamin D3 in patients after hip replacement for fractured neck of femur or osteoarthritis. | 1996 | Eur. J. Clin. Invest. | pmid:8682151 |
| Besson-Leaud M et al. | [Prophylaxis of late hemorrhagic disease in newborn infants with vitamin K1 at birth]. | 1996 | Arch Pediatr | pmid:8745836 |
| Israels LG and Israels ED | Observations on vitamin K deficiency in the fetus and newborn: has nature made a mistake? | 1995 | Semin. Thromb. Hemost. | pmid:8747698 |
| Moreau-Cabarrot A et al. | [Cutaneous hypersensitivity at the site of injection of vitamin K1]. | 1996 | Ann Dermatol Venereol | pmid:8761778 |
| Hagstrom JN et al. | The pharmacokinetics and lipoprotein fraction distribution of intramuscular vs. oral vitamin K1 supplementation in women of childbearing age: effects on hemostasis. | 1995 | Thromb. Haemost. | pmid:8772225 |
| Baum CR et al. | Accidental administration of an ergot alkaloid to a neonate. | 1996 | Pediatrics | pmid:8784375 |
| Thijssen HH and Drittij-Reijnders MJ | Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4. | 1996 | Br. J. Nutr. | pmid:8785182 |
| Fauler G et al. | Method for the determination of vitamin K1(20) in human plasma by stable isotope dilution/gas chromatography/mass spectrometry. | 1996 | J Mass Spectrom | pmid:8799299 |
| Soedirman JR et al. | Pharmacokinetics and tolerance of intravenous and intramuscular phylloquinone (vitamin K1) mixed micelles formulation. | 1996 | Br J Clin Pharmacol | pmid:8799516 |
| Gijsbers BL et al. | Effect of food composition on vitamin K absorption in human volunteers. | 1996 | Br. J. Nutr. | pmid:8813897 |
| Weathermon RA et al. | Comment: oral vitamin K1 to reverse warfarin activity. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826584 |
| Loughnan PM and McDougall PN | Does intramuscular vitamin K1 act as an unintended depot preparation? | 1996 | J Paediatr Child Health | pmid:8827545 |
| Loughnan PM et al. | Late onset haemorrhagic disease in premature infants who received intravenous vitamin K1. | 1996 | J Paediatr Child Health | pmid:8827551 |
| Booth SL et al. | Plasma concentrations of dihydro-vitamin K1 following dietary intake of a hydrogenated vitamin K1-rich vegetable oil. | 1996 | Lipids | pmid:8827693 |
| Booth SL et al. | Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. | 1996 | Lipids | pmid:8827694 |
| Shearer MJ et al. | Effect of warfarin on the metabolism of phylloquinone (vitamin K1):dose-response relationships in man. | 1977 | Clin Sci Mol Med | pmid:884934 |
| Stoeckel K et al. | Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn. | 1996 | Eur. J. Clin. Pharmacol. | pmid:8866641 |
| Sundaram KS et al. | Vitamin K status influences brain sulfatide metabolism in young mice and rats. | 1996 | J. Nutr. | pmid:8914944 |
| Imanaka M et al. | Identification of phylloquinone (vitamin K1) as an unknown peak in electron capture detection gas chromatograms of pyrethroid insecticide residues. | 1996 Mar-Apr | J AOAC Int | pmid:8920143 |
| Pang BK et al. | Pseudoscleroderma secondary to phytomenadione (vitamin K1) injections: Texier's disease. | 1996 | Australas. J. Dermatol. | pmid:8936071 |
| Tabushi I et al. | One-step preparation of vitamin K1 or K2 analogues by cyclodextrin inclusion catalysis. | 1977 | J. Am. Chem. Soc. | pmid:893897 |
| Bach AU et al. | Assessment of vitamin K status in human subjects administered "minidose" warfarin. | 1996 | Am. J. Clin. Nutr. | pmid:8942414 |
| Ronden JE et al. | Natural prenylquinones inhibit the enzymes of the vitamin K cycle in vitro. | 1996 | Biochim. Biophys. Acta | pmid:8948492 |
| Sakamoto N et al. | Changes of phylloquinone and menaquinone-4 concentrations in rat liver after oral, intravenous and intraperitoneal administration. | 1996 | Int J Vitam Nutr Res | pmid:8979160 |