| MeSH term | MeSH ID | Detail |
|---|---|---|
| Exanthema | D005076 | 11 associated lipids |
| Thromboembolism | D013923 | 6 associated lipids |
| Vitamin K Deficiency | D014813 | 5 associated lipids |
Total
3
phylloquinone
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phylloquinone?
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with phylloquinone
PubChem Associated disorders and diseases
What pathways are associated with phylloquinone
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phylloquinone?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with phylloquinone?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with phylloquinone?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with phylloquinone?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phylloquinone?
Knock-out
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with phylloquinone
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thane CW et al. | Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people. | 2002 | Br. J. Nutr. | pmid:12067431 |
| Olson RE et al. | Total body phylloquinone and its turnover in human subjects at two levels of vitamin K intake. | 2002 | Br. J. Nutr. | pmid:12067424 |
| Sato T et al. | Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats. | 2002 | Br. J. Nutr. | pmid:12064340 |
| Thijssen HH et al. | Menaquinone-4 in breast milk is derived from dietary phylloquinone. | 2002 | Br. J. Nutr. | pmid:12064330 |
| Binkley N et al. | Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats. | 2002 | Bone | pmid:12052460 |
| McKeown NM et al. | Dietary and nondietary determinants of vitamin K biochemical measures in men and women. | 2002 | J. Nutr. | pmid:12042454 |
| Konoplia NA et al. | [Effects of riboxin, essentiale, and phylloquinone on the immunomodulating and antioxidant effect of laser and magneto-laser irradiation in liver toxicosis induced by gentamycin]. | 2002 Jan-Feb | Eksp Klin Farmakol | pmid:12025789 |
| Nakamura A and Watanabe T | Separation and determination of minor photosynthetic pigments by reversed-phase HPLC with minimal alteration of chlorophylls. | 2001 | Anal Sci | pmid:11990566 |
| Schurgers LJ and Vermeer C | Differential lipoprotein transport pathways of K-vitamins in healthy subjects. | 2002 | Biochim. Biophys. Acta | pmid:11960685 |
| Knauer TE et al. | Metabolism and biological activity of cis- and trans-phylloquinone in the rat. | 1975 | J. Nutr. | pmid:1195014 |
| Tsang CK and Kamei Y | Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. | 2002 | Neurosci. Lett. | pmid:11911978 |
| Newman P et al. | The uptake of lipoprotein-borne phylloquinone (vitamin K1) by osteoblasts and osteoblast-like cells: role of heparan sulfate proteoglycans and apolipoprotein E. | 2002 | J. Bone Miner. Res. | pmid:11874234 |
| Asakura H et al. | Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. | 2001 | Osteoporos Int | pmid:11846334 |
| Riegert-Johnson DL et al. | A patient with anaphylactoid hypersensitivity to intravenous cyclosporine and subcutaneous phytonadione (vitamin K(1)). | 2001 | Bone Marrow Transplant. | pmid:11803365 |
| Hansen HH | [Practical aspects of peroral anticoagulant treatment]. | 2001 | Ugeskr. Laeg. | pmid:11794049 |
| Greer FR | Are breast-fed infants vitamin K deficient? | 2001 | Adv. Exp. Med. Biol. | pmid:11787707 |
| Okayasu H et al. | Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines. | 2001 Jul-Aug | Anticancer Res. | pmid:11724297 |
| Booth SL et al. | Effects of a hydrogenated form of vitamin K on bone formation and resorption. | 2001 | Am. J. Clin. Nutr. | pmid:11722960 |
| Rigby SE et al. | Electron nuclear double resonance (ENDOR) spectroscopy of radicals in photosystem I and related Type 1 photosynthetic reaction centres. | 2001 | Biochim. Biophys. Acta | pmid:11687218 |
| Deligiannakis Y and Rutherford AW | Electron spin echo envelope modulation spectroscopy in photosystem I. | 2001 | Biochim. Biophys. Acta | pmid:11687217 |
| Bittl R and Zech SG | Pulsed EPR spectroscopy on short-lived intermediates in Photosystem I. | 2001 | Biochim. Biophys. Acta | pmid:11687215 |
| Itoh S et al. | Modification of photosystem I reaction center by the extraction and exchange of chlorophylls and quinones. | 2001 | Biochim. Biophys. Acta | pmid:11687211 |
| Brettel K and Leibl W | Electron transfer in photosystem I. | 2001 | Biochim. Biophys. Acta | pmid:11687210 |
| Ghosh K et al. | Congenital deficiency of vitamin K dependent coagulation factors--its rarity and need for an international registry. | 2001 | Thromb. Haemost. | pmid:11686345 |
| Kawana K et al. | Circulating levels of vitamin K1, menaquinone-4, and menaquinone-7 in healthy elderly Japanese women and patients with vertebral fractures and patients with hip fractures. | 2001 | Endocr. Res. | pmid:11678581 |
| Owens DE et al. | Retropharyngeal hematoma. A complication of therapy with anticoagulants. | 1975 | Arch Otolaryngol | pmid:1164240 |
| Summaries for patients. Predicting risk for prolonged high INR after too much anticoagulation. | 2001 | Ann. Intern. Med. | pmid:11575277 | |
| Hylek EM et al. | Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin. | 2001 | Ann. Intern. Med. | pmid:11560452 |
| Vermeer C et al. | Bone markers during a 6-month space flight: effects of vitamin K supplementation. | 1998 | J Gravit Physiol | pmid:11541904 |
| Vermeer C and Ulrich MM | The effect of microgravity on plasma-osteocalcin. | 1986 | Adv Space Res | pmid:11537812 |
| Udagawa M and Murai T | Content of phylloquinone and menaquinone in the tissues of mummichog Fundulus heteroclitus fed diets containing different forms of vitamin K. | 2001 | J. Nutr. Sci. Vitaminol. | pmid:11508712 |
| Boudreaux B et al. | Mutations in both sides of the photosystem I reaction center identify the phylloquinone observed by electron paramagnetic resonance spectroscopy. | 2001 | J. Biol. Chem. | pmid:11489879 |
| Valko M et al. | Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer? | 2001 | Biochim. Biophys. Acta | pmid:11479033 |
| Johnson TW et al. | Recruitment of a foreign quinone into the A1 site of photosystem I. In vivo replacement of plastoquinone-9 by media-supplemented naphthoquinones in phylloquinone biosynthetic pathway mutants of Synechocystis sp. PCC 6803. | 2001 | J. Biol. Chem. | pmid:11470786 |
| Gettler SL and Fung MA | Off-center fold: indurated plaques on the arms of a 52-year-old man. Diagnosis: Cutaneous reaction to phytonadione injection. | 2001 | Arch Dermatol | pmid:11453820 |
| Walz DA et al. | Effects of vitamin K deficiency, warfarin, and inhibitors of protein synthesis upon the plasma levels of vitamin K-dependent clotting factors in the chick. | 1975 | J. Nutr. | pmid:1142015 |
| Burgess TM et al. | Practitioner report involving intravenous use of vitamin K1 prompts label review and revision. | 2001 | J. Am. Vet. Med. Assoc. | pmid:11394826 |
| Schurgers LJ et al. | Role of vitamin K and vitamin K-dependent proteins in vascular calcification. | 2001 | Z Kardiol | pmid:11374034 |
| Jin S and Sell JL | Dietary vitamin K1 requirement and comparison of biopotency of different vitamin K sources for young turkeys. | 2001 | Poult. Sci. | pmid:11372711 |
| Jin S et al. | Effect of dietary vitamin K1 on selected plasma characteristics and bone ash in young turkeys fed diets adequate or deficient in vitamin D3. | 2001 | Poult. Sci. | pmid:11372710 |
| Kaneki M et al. | Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. | 2001 | Nutrition | pmid:11369171 |
| Schurgers LJ and Vermeer C | Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. | 2000 Nov-Dec | Haemostasis | pmid:11356998 |
| Begent LA et al. | Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. | 2001 | J. Pharm. Pharmacol. | pmid:11341364 |
| Purton S et al. | Site-directed mutagenesis of PsaA residue W693 affects phylloquinone binding and function in the photosystem I reaction center of Chlamydomonas reinhardtii. | 2001 | Biochemistry | pmid:11329285 |
| Koivu-Tikkanen TJ et al. | Determination of phylloquinone and menaquinones in animal products with fluorescence detection after postcolumn reduction with metallic zinc. | 2000 | J. Agric. Food Chem. | pmid:11312804 |
| Hastings G and Sivakumar V | A Fourier transform infrared absorption difference spectrum associated with the reduction of A1 in photosystem I: are both phylloquinones involved in electron transfer? | 2001 | Biochemistry | pmid:11297436 |
| Mulcahy JJ et al. | Transurethral prostatic resection in patients with prosthetic cardiac valves. | 1975 | J. Urol. | pmid:1127807 |
| Mitchell GV et al. | Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4. | 2001 | Int J Vitam Nutr Res | pmid:11276919 |
| Cushman M et al. | The association of vitamin K status with warfarin sensitivity at the onset of treatment. | 2001 | Br. J. Haematol. | pmid:11260056 |
| Shields RC et al. | Efficacy and safety of intravenous phytonadione (vitamin K1) in patients on long-term oral anticoagulant therapy. | 2001 | Mayo Clin. Proc. | pmid:11243272 |