MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kowdley KV et al. | Plasma vitamin K1 level is decreased in primary biliary cirrhosis. | 1997 | Am. J. Gastroenterol. | pmid:9362192 |
Bittl R et al. | Pulsed EPR structure analysis of photosystem I single crystals: localization of the phylloquinone acceptor. | 1997 | Biochemistry | pmid:9340008 |
Hanley J et al. | ESEEM study of the phyllosemiquinone radical A1.- in 14N- and 15N-labeled photosystem I. | 1997 | Biochemistry | pmid:9340006 |
Booth SL and Sadowski JA | Determination of phylloquinone in foods by high-performance liquid chromatography. | 1997 | Meth. Enzymol. | pmid:9330309 |
Usui Y | Assay of phylloquinone and menaquinones in human liver. | 1997 | Meth. Enzymol. | pmid:9330308 |
McCarthy PT et al. | Assay of phylloquinone in plasma by high-performance liquid chromatography with electrochemical detection. | 1997 | Meth. Enzymol. | pmid:9330306 |
Davidson KW and Sadowski JA | Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. | 1997 | Meth. Enzymol. | pmid:9330305 |
Konoplia EN et al. | [Hepatoprotective and immunomodulating effect of phylloquinone in toxic damage to the liver]. | 1997 May-Jun | Eksp Klin Farmakol | pmid:9324408 |
Frank J et al. | Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks. | 1997 | Int J Vitam Nutr Res | pmid:9285253 |
MacMillan F et al. | Orientation of the phylloquinone electron acceptor anion radical in photosystem I. | 1997 | Biochemistry | pmid:9280439 |