MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Exanthema | D005076 | 11 associated lipids |
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Seeman P and Guan HC | Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors. | 2009 | Synapse | pmid:19391149 |
Crisler C et al. | Intestinal obstruction in patients receiving anticoagulants. | 1970 | Surg. Clin. North Am. | pmid:5469456 |
Reumann S | Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways. | 2013 | Subcell. Biochem. | pmid:23821151 |
Sato Y et al. | Long-term oral anticoagulation reduces bone mass in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation. | 1997 | Stroke | pmid:9412619 |
Isarangkura PB et al. | The different levels of vitamin K1 and K2 in the maternal breast-milk of infants with acquired prothrombin complex deficiency syndrome. | 1987 | Southeast Asian J. Trop. Med. Public Health | pmid:3448782 |
Mueller RJ et al. | Hypoprothrombinemia associated with cefoperazone therapy. | 1987 | South. Med. J. | pmid:3686136 |
Shafer AW | Use of blood and blood components. | 1975 | South. Med. J. | pmid:1093259 |
Clarke P and Shearer MJ | Vitamin K deficiency bleeding after missed prophylaxis: rapid synergistic effect of vitamin K therapy on hemostasis. | 2007 | South. Med. J. | pmid:17593579 |
MATSUOKA M | [IMPROVEMENT AND EXACERBATION IN LEUKEMIA]. | 1963 | Sogo Rinsho | pmid:14096537 |
da Silva AL et al. | Vitamin K1-loaded lipid-core nanocapsules: physicochemical characterization and in vitro skin permeation. | 2013 | Skin Res Technol | pmid:22672012 |
Zheng Y and Chao RB | [Isolation and structure identification of the main photolysis product in vitamin K1]. | 2005 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:16235548 |
Sakamaki N et al. | [Determination of vitamin K in aojiru (green juice) products by HPLC]. | 2006 | Shokuhin Eiseigaku Zasshi | pmid:16729670 |
Haustein KO | Pharmacokinetic and pharmacodynamic properties of oral anticoagulants, especially phenprocoumon. | 1999 | Semin. Thromb. Hemost. | pmid:10327214 |
Israels LG and Israels ED | Observations on vitamin K deficiency in the fetus and newborn: has nature made a mistake? | 1995 | Semin. Thromb. Hemost. | pmid:8747698 |
Israels LG et al. | The riddle of vitamin K1 deficit in the newborn. | 1997 | Semin. Perinatol. | pmid:9190038 |
Li G et al. | [Analysis of vitamin K1 in Cephalanoplos segetum (Bunge) Kitam by high performance liquid chromatography]. | 1997 | Se Pu | pmid:15739380 |
Dowd P et al. | Vitamin K and energy transduction: a base strength amplification mechanism. | 1995 | Science | pmid:7569894 |
Gutnick DL et al. | Cis-trans isomerism in naphthoquinones: interconversion and participation in oxidative phosphorylation. | 1967 | Science | pmid:4293760 |
Lowenthal J and Birnbaum H | Vitamin K and coumarin anticoagulants: dependence of anticoagulant effect on inhibition of vitamin K transport. | 1969 | Science | pmid:5774189 |
Caviezel O | [Ambulatory therapy with antivitamins K]. | 1971 | Schweiz. Rundsch. Med. Prax. | pmid:5549861 |