phylloquinone

Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phylloquinone?

phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with phylloquinone

MeSH term MeSH ID Detail
Exanthema D005076 11 associated lipids
Thromboembolism D013923 6 associated lipids
Vitamin K Deficiency D014813 5 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with phylloquinone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phylloquinone?

Related references are published most in these journals:

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What functions are associated with phylloquinone?


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What lipids are associated with phylloquinone?

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What genes are associated with phylloquinone?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phylloquinone?

Knock-out

Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).

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NCBI Entrez Crosslinks

All references with phylloquinone

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Authors Title Published Journal PubMed Link
Fasco MJ et al. Formation of hydroxyvitamin K by vitamin K epoxide reductase of warfarin-resistant rats. 1983 J. Biol. Chem. pmid:6833262
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Boothman BR Problems with anticoagulants. 1982 Aug 28-Sep 4 Br Med J (Clin Res Ed) pmid:6819048
Barlow AM et al. Difenacoum (Neosorexa) poisoning. 1982 Br Med J (Clin Res Ed) pmid:6809162
Fasco MJ and Principe LM Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase. 1982 Biochem. Biophys. Res. Commun. pmid:6803779
Vermeer C et al. A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows. 1982 Biochim. Biophys. Acta pmid:6799008
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Langenberg JP and Tjaden UR Improved method for the determination of vitamin K1 epoxide in human plasma with electrofluorimetric reaction detection. 1984 J. Chromatogr. pmid:6736159
Preusch PC and Suttie JW Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. 1984 J. Nutr. pmid:6726460
Hart JP et al. Voltammetric behaviour of phylloquinone (vitamin K1) at a glassy-carbon electrode and determination of the vitamin in plasma using high-performance liquid chromatography with electrochemical detection. 1984 Analyst pmid:6721166
Bechtold H et al. Improved method for quantitative analysis of vitamin K1 and vitamin K1 2,3-epoxide in human plasma by electron-capture gas-liquid capillary chromatography. 1984 J. Chromatogr. pmid:6715470
Canfield LM and Ramelow U Vitamin K-dependent carboxylase: evidence for a semiquinone radical intermediate. 1984 Arch. Biochem. Biophys. pmid:6712248
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Langenberg JP and Tjaden UR Determination of (endogenous) vitamin K1 in human plasma by reversed-phase high-performance liquid chromatography using fluorometric detection after post-column electrochemical reduction. Comparison with ultraviolet, single and dual electrochemical detection. 1984 J. Chromatogr. pmid:6707155
Wilson AC and Park BK The effect of phenobarbitone pre-treatment on vitamin K1 disposition in the rat and rabbit. 1984 Biochem. Pharmacol. pmid:6704138
Kanabus-Kaminska JM and Girardot JM Inhibition of vitamin K-dependent carboxylase by metal ions and metal complexes: a reassessment. 1984 Arch. Biochem. Biophys. pmid:6696452
Mount ME and Feldman BF Mechanism of diphacinone rodenticide toxicosis in the dog and its therapeutic implications. 1983 Am. J. Vet. Res. pmid:6689111
Bechtold H et al. Cyclic interconversion of vitamin K1 and vitamin K1 2,3-epoxide in man. 1983 Br J Clin Pharmacol pmid:6661354
Kutsop JJ Vitamin K1 content of enteral products. 1983 Am J Hosp Pharm pmid:6660224
Fasco MJ et al. Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes. 1983 Biochemistry pmid:6652076
Wilson AC and Park BK Quantitative analysis of pharmacological levels of vitamin K1 and vitamin K1 2,3-epoxide in rabbit plasma by high-performance liquid chromatography. 1983 J. Chromatogr. pmid:6643613
Pennock JF The biosynthesis of chloroplastidic terpenoid quinones and chromanols. 1983 Biochem. Soc. Trans. pmid:6642059
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Ueno T and Suttie JW High-pressure liquid chromatographic-reductive electrochemical detection analysis of serum trans-phylloquinone. 1983 Anal. Biochem. pmid:6638487
Kammermann-Lüscher B [Coumarin poisoning in dog and cat]. 1978 Schweiz. Arch. Tierheilkd. pmid:663601
Shanahan F et al. Factor V deficiency and its reversal with gluten restriction. In a patient with celiac disease. 1983 Arch. Intern. Med. pmid:6625791
Horn GB Determination of phytonadione in elemental diets by TLC-spectrophotodensitometry. 1978 J Pharm Sci pmid:660469
Garvey WT and Olson RE In vitro vitamin K-dependent conversion of precursor to prothrombin in chick liver. 1978 J. Nutr. pmid:660301
Bechtold H et al. Evidence for impaired hepatic vitamin K1 metabolism in patients treated with N-methyl-thiotetrazole cephalosporins. 1984 Thromb. Haemost. pmid:6548584
McGehee WG et al. Coumarin necrosis associated with hereditary protein C deficiency. 1984 Ann. Intern. Med. pmid:6547283
Haustein KO Interaction between phenprocoumon and phytomenadion: a pharmacokinetic investigation in healthy volunteers. 1984 Biomed. Biochim. Acta pmid:6534380
Park BK et al. Plasma disposition of vitamin K1 in relation to anticoagulant poisoning. 1984 Br J Clin Pharmacol pmid:6508974
Napoli JL and Beck CD Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis. 1984 Biochem. J. pmid:6497842
Hart JA et al. A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits. 1984 Biochem. Pharmacol. pmid:6487353
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Kutsop JJ Update on vitamin K1 content of enteral products. 1984 Am J Hosp Pharm pmid:6437219
Hanck A and Weiser H Physiological and pharmacological effects of vitamin K. 1983 Int J Vitam Nutr Res Suppl pmid:6414967
Vitamin K hydroperoxide: an intermediate in gamma-glutamate carboxylation? 1984 Nutr. Rev. pmid:6384837
van Amstel WJ et al. Successful prevention of coumarin-induced hemorrhagic skin necrosis by timely administration of vitamin k1. 1978 Blut pmid:638263
Olson RE The function and metabolism of vitamin K. 1984 Annu. Rev. Nutr. pmid:6380538
Megavitamin E supplementation and vitamin K-dependent carboxylation. 1983 Nutr. Rev. pmid:6358960
Conversion of vitamin K epoxide to hydroxyvitamin K by liver microsomes from warfarin-resistant rats. 1983 Nutr. Rev. pmid:6355923
Israels LG et al. Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice. 1983 J. Clin. Invest. pmid:6304144
Sloane N Enzymic hydroxylation of benzo(alpha)pyrene at the 6-position by vitamin K1-hydroperoxide and rat lung hydroperoxidase. 1981 Xenobiotica pmid:6272502
Bieri JG and McKenna MC Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. 1981 Am. J. Clin. Nutr. pmid:6259921
Hollander D and Rim E Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. 1978 Am. J. Physiol. pmid:623249
McBurney A et al. Changes in the urinary metabolites of phylloquinone (vitamin K1) in man following therapeutic anticoagulation with warfarin. 1978 Biochem. Pharmacol. pmid:619911